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Scientific Papers/Award

Three dimensional analysis of ribonucleoprotein complexes in influenza A virus

Nature Communications Vol.3, 639 doi:10.1038/ncomms1647
Takeshi Noda, Yukihiko Sugita, Kazuhiro Aoyama, Ai Hirase, Eiryo Kawakami, Atsuo Miyazawa, Hiroshi Sagara, Yoshihiro Kawaoka

A Tecpr1-dependent selective autophagy pathway targets bacterial pathogens

Michinaga Ogawa1, Yuko Yoshikawa1, Taira Kobayashi1, Hitomi Mimuro1, Makoto Fukumatsu1, Kotaro Kiga1, Zhenzi Piao1, Hiroshi Ashida1, Mitsutaka Yoshida2, Shigeru Kakuta3,*, Tomohiro Koyama4, Yoshiyuki Goto5, Takahiro Nagatake5, Shinya Nagai4, Hiroshi Kiyono5, Magdalena Kawalec6, Jean-Marc Reichhart6 and Chihiro Sasakawa1, 7
1Division of Bacterial Infection, 5Division of Mucosal Immunology, Department of Microbiology and Immunology, 3Center for Experimental Medicine and Systems Biology, Institute of Medical Science, The University of Toky, 2Division of Ultrastructural Research, BioMedical Research Center, Graduate School of Medicine, Juntendo University, 4Nippon Institute for Biological Science, 6IUF-UdS, IBMC UPR 9022 CNRS, 7Department of Infectious Disease Control, International Research Center for Infectious Diseases, Institute of Medical Science, The University of Tokyo

Non-myelinating Schwann cells maintain hematopoietic stem cell hibernation in the bone marrow niche

Cell 147, 1146-1158, November 23, 2011
Satoshi Yamazaki1, Hideo Ema3, Göran Karlsson4, Tomoyuki Yamaguchi1, 3, Hiroyuki Miyoshi5, 6, Seiji Shioda7, Makoto M. Taketo5, Stefan Karlsson4, Atsushi Iwama2, 8, and Hiromitsu Nakauchi1, 3
1Japan Science and Technology Agency (JST), ERATO and 2CREST, Sanbancho, Chiyoda-ku, Tokyo 102-0075, Japan. 3Division of Stem Cell Therapy, Center for Stem Cell Biology and Medicine, Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan. 4Department of Molecular Medicine and Gene Therapy, Lund Stem Cell Center, Lund University Hospital, BMC A12, 221 84, Lund, Sweden. 5 Department of Pharmacology, Graduate School of Medicine, Kyoto University, Kyoto 606-8501, Japan. 6 Present address: Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA. 7 Department of Anatomy, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan. 8Department of Cellular and Molecular Medicine, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan.

Unc93B1 Restricts Systemic Lethal Inflammation by Orchestrating Toll-like Receptor 7 and 9 Trafficking

Immunity 2011 Jun 15. [Epub ahead of print]
Ryutaro Fukui, Shin-Ichiroh Saitoh, Atsuo Kanno, Masahiro Onji, Takuma Shibata, Akihiko Ito, Morikazu Onji, Mitsuru Matsumoto, Shizuo Akira, Nobuaki Yoshida, and Kensuke Miyake
Division of Infectious Genetics, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minatoku, Tokyo 108-8639, Japan.

Dr. Yoshihiro Kawaoka is awarded the Medal with Purple Ribbon

 

Genome-wide association study identifies a susceptibility locus for HCV-induced hepatocellular carcinoma

Nature Genetics doi:10.1038/ng.809.
Vinod Kumar,Naoya Kato,Yuji Urabe,Atsushi Takahashi,Ryosuke Muroyama,Naoya Hosono,Motoyuki Otsuka,Ryosuke Tateishi,Masao Omata,Hidewaki Nakagawa,Kazuhiko Koike,Naoyuki Kamatani,Michiaki Kubo,Yusuke Nakamura & Koichi Matsuda
Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, University of Tokyo, Tokyo, Japan. Center for Genomic Medicine, The Institute of Physical and Chemical Research (RIKEN), Kanagawa, Japan. Unit of Disease Control Genome Medicine, The Institute of Medical Science, University of Tokyo, Tokyo, Japan. Department of Gastroenterology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.

Oncogenic Ras abrogates MEK SUMOylation that suppresses the ERK pathway and cell transformation

Nat Cell Biol. 2011 Mar;13(3):282-91. Epub 2011 Feb 20.
Kubota Y, O'Grady P, Saito H, Takekawa M.
[1] Department of Molecular Cell Signaling, Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan [2] Department of Biophysics and Biochemistry, Graduate School of Science, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan [3] Department of Cell Signaling and Molecular Medicine, Research Institute of Environmental Medicine, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8601, Japan.

Crosstalk between Glucocorticoid Receptor and Nutritional Sensor mTOR in Skeletal Muscle

Cell Metab. 2011 Feb 2;13(2):170-82.
Shimizu N, Yoshikawa N, Ito N, Maruyama T, Suzuki Y, Takeda S, Nakae J, Tagata Y, Nishitani S, Takehana K, Sano M, Fukuda K, Suematsu M, Morimoto C, Tanaka H.
Division of Clinical Immunology, Advanced Clinical Research Center, Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan.

Birth and death of genes linked to chromosomal inversion

PNAS January 6, 2011.
Yoshikazu Furuta, Mikihiko Kawaia, Koji Yahara, Noriko Takahashi, Naofumi Handa, Takeshi Tsuru, Kenshiro Oshima, Masaru Yoshida, Takeshi Azuma, Masahira Hattori, Ikuo Uchiyama, Ichizo Kobayashi.
a:Department of Medical Genome Sciences, Graduate School of Frontier Sciences, University of Tokyo, Minato-ku, Tokyo 108-8639, Japan;b:Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639, Japan;c:Laboratory of Genome Informatics, National Institute for Basic Biology, National Institutes of Natural Sciences, Okazaki, Aichi 444-8585, Japan;d:Graduate School of Medicine, Kurume University, Kurume, Fukuoka 830-0011, Japan;e:Fujitsu Kyushu Systems Ltd., Fukuoka, Fukuoka 814-8589, Japan;f:Department of Biophysics and Biochemistry, Graduate School of Science, University of Tokyo, Minato-ku, Tokyo 108-8639, Japan;g:Department of Computational Biology, Graduate School of Frontier Sciences, University of Tokyo, Kashiwa, Chiba 277-8561, Japan;h:Department of Gastroenterology, Graduate School of Medicine, Kobe University, Chuou-ku, Kobe, Hyogo 650-0017, Japan

Transient activation of c-MYC expression is critical for efficient platelet generation from human induced pluripotent stem cells

J Exp Med. 2010 Nov 22.
Takayama N, Nishimura S, Nakamura S, Shimizu T, Ohnishi R, Endo H, Yamaguchi T, Otsu M, Nishimura K, Nakanishi M, Sawaguchi A, Nagai R, Takahashi K, Yamanaka S, Nakauchi H, Eto K.
Stem Cell Bank and 2 Division of Stem Cell Therapy, Center for Stem Cell Biology and Regenerative Medicine, the Institute of Medical Science, and 3 Department of Cardiovascular Medicine and 5 Translational Systems Biology and Medicine Initiative, the University of Tokyo, Tokyo 113-0033, Japan.
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