The Institute of Medical Science, The University of Tokyo

Home > Scientific Papers

Scientific Papers

A bacterial E3 ubiquitin ligase IpaH9.8 targets NEMO/IKKγ to dampen the host NF-κB-mediated inflammatory response

Nature Cell Biology　DOI 10. 1038/ncb2006

Hiroshi Ashida1,2, Minsoo Kim2, Marc Schmidt-Supprian3, Averil Ma4, Michinaga Ogawa1 & Chihiro Sasakawa1,2

1. Department of Microbiology and Immunology, University of Tokyo, 4-6-1, Shirokanedai, Minato-ku, Tokyo 108-8639, Japan. 2. Department of Infectious Disease Control, International Research Center for Infectious Disease, Institute of Medical Science, University of Tokyo, 4-6-1, Shirokanedai, Minato-ku, Tokyo 108-8639, Japan. 3. Max Planck Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany. 4. Department of Medicine, University of California at San Francisco, 513 Parnassus Avenue, S-1057, San Francisco, CA 94143-0451, USA.

Two mechanistically and temporally distinct NF-kappaB activation pathways in IL-1 signaling

Sci Signal. 2009 Oct 20;2(93):ra66.

Yamazaki K, Gohda J, Kanayama A, Miyamoto Y, Sakurai H, Yamamoto M, Akira S, Hayashi H, Su B, Inoue J.

Division of Cellular and Molecular Biology, Department of Cancer Biology, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639, Japan.

Structural basis for translational fidelity ensured by transfer RNA lysidine synthetase

Nature 461, 1144-1148 (2009)

Kotaro Nakanishi1,4, Luc Bonnefond2, Satoshi Kimura3, Tsutomu Suzuki3, Ryuichiro Ishitani2 & Osamu Nureki1,2

1. Department of Biological Information, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Yokohama, Kanagawa 225-8501, Japan 2. Department of Basic Medical Sciences, Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan 3. Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan 4. Present address: Structural Biology Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA.

Listeria monocytogenes ActA-mediated escape from autophagic recognition

Nature Cell Biology DOI 10.1038/ncb1967 (2009)

Yuko Yoshikawa1, Michinaga Ogawa1, Torsten Hain2, Mitsutaka Yoshida3, Makoto Fukumatsu1, Minsoo Kim4, Hitomi Mimuro1, Ichiro Nakagawa4, Toru Yanagawa5, Tetsuro Ishii5, Akira Kakizuka6, Elizabeth Sztul7, Trinad Chakraborty2 & Chihiro Sasakawa1,4,8

1. Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo, 4-6-1, Shirokanedai, Minato-Ku, Tokyo 108-8639, Japan. 2. Institute of Medical Microbiology, Justus-Liebig University Giessen, Frankfurter Strasse 107, D-35392, Giessen, Germany. 3. Division of Ultrastructual Research, BioMedical Research Center, Graduate School of Medicine, Juntendo University, 2-1-1, Hongo, Bunkyo-ku, Tokyo 113-8421, Japan. 4. Department of Infectious Disease Control, International Research Center for Infectious Diseases, The Institute of Medical Science, The University of Tokyo, 4-6-1, Shirokanedai, Minato-Ku, Tokyo 108-8639, Japan. 5. Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1-1-1, Tennodai, Tsukuba, Ibaraki 305-8575, Japan. 6. Kyoto University Graduate School of Biostudies and Solution Oriented Research for Science and Technology (JST), Kyoto 606-8501, Japan. 7. Department of Cell Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA. 8. CREST, Japan Science and Technology Agency, Kawaguchi 332–0012, Japan.

Bacteria hijack integrin-linked kinase to stabilize focal adhesions and block cell detachment

Nature DOI 10.1038/nature07952 (2009)

Minsoo Kim1,3, Michinaga Ogawa2,3, Yukihiro Fujita2,3, Yuko Yoshikawa2,3, Takeshi Nagai2,3, Tomohiro Koyama4, Shinya Nagai4, Anika Lange5, Reinhard Fassler5 & Chihiro Sasakawa1,2,3

1. Department of Infectious Disease Control, International Research Center for Infectious Diseases, 2. Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, 4-6-1, Shirokanedai, Minato-ku, Tokyo 108-8639, Japan 3. CREST, Japan Science and Technology Agency, Kawaguchi 332-0012, Japan 4. Nippon Institute for Biological Science, 9-2221-1, Shinmachi, Ome, Tokyo 198-0024, Japan 5. Department of Molecular Medicine, Max-Planck Institute of Biochemistry, D-82152, Martinsried, Germany

Dok-7 activates the muscle receptor kinase MuSK and shapes synapse formation

Science Signaling 2: ra7, 2009

Akane Inoue1, Kiyoko Setoguchi2, Yosuke Matsubara2, Kumiko Okada2, Nozomi Sato3, Yoichiro Iwakura3, Osamu Higuchi1, Yuji Yamanashi1.

1Division of Genetics, Department of Cancer Biology, Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan. 2Department of Cell Regulation, Medical Research Institute, Tokyo Medical and Dental University, Tokyo 113-8510, Japan. 3Division of Cell Biology, Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan.

Differential roles of interleukin-17A and -17F in host defense against mucoepithelial bacterial infection and allergic responses

Immunity 30 (1):108-119, 2009

Harumichi Ishigame1, Shigeru Kakuta1, Takeshi Nagai2, Motohiko Kadoki1, Aya Nambu1, Yutaka Komiyama1, Noriyuki Fujikado1, Yuko Tanahashi1, Aoi Akitsu1, Hayato Kotaki1, Katsuko Sudo1,5, Susumu Nakae1, 3, Chihiro Sasakawa2, & Yoichiro Iwakura1, 4

1Center for Experimental Medicine, 2Department of Microbiology and Immunity, 3 Frontier Research Initiative, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo, 108-8639, Japan. 4Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency, Saitama 332-0012, Japan. 5Present address: Animal Research Center, Tokyo Medical University, 6-1-1 Shinjyuku, Shinjyuku-ku, Tokyo 160-8402, Japan.

- | Next

PAGE TOP