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Scientific Papers/Award

Microbe-dependent CD11b+ IgA+ plasma cells in early-phase robust intestinal IgA responses in mice

Nature Communications 4, 1772 doi:10.1038/ncomms2718
Jun Kunisawa, Masashi Gohda, Eri Hashimoto, Izumi Ishikawa, Morio Higuchi, Yuji Suzuki, Yoshiyuki Goto, Casandra Panea, Ivaylo I. Ivanov, Risa Sumiya, Lamichhane Aayam, Taichi Wake, So Tajiri, Yosuke Kurashima, Shiori Shikata, Shizuo Akira, Kiyoshi Takeda & Hiroshi Kiyono
Division of Mucosal Immunology, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan
Department of Medical Genome Science, Graduate School of Frontier Science, The University of Tokyo, Chiba 277-8562, Japan
International Research and Development Center for Mucosal Vaccines, The Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan
Laboratory of Vaccine Materials, National Institute of Biomedical Innovation, Osaka 567-0085, Japan
Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, Tokyo 102-0075, Japan
Graduate School of Medicine, The University of Tokyo, Tokyo 113-0033, Japan
Department of Microbiology and Immunology, Columbia University Medical Center, New York, New York 10032, USA
Laboratory of Host Defense, WPI Immunology Frontier Research Center, Osaka University, Osaka 565-0871, Japan
Laboratory of Immune Regulation, Department of Microbiology and Immunology, Graduate School of Medicine, Osaka University, Osaka 565-0871, Japan

Generation of rejuvenated antigen-specific T cells by reprogramming to pluripotency and redifferentiation

Cell Stem Cell 12 2013, 114-126, doi: http://dx.doi.org/10.1016/j.stem.2012.11.002.
Nishimura T, Kaneko S, Kawana-Tachikawa A, Tajima Y, Goto H, Zhu D, Nakayama-Hosoya K, Iriguchi S, Uemura Y, Shimizu T, Takayama N, Yamada D, Nishimura K, Ohtaka M, Watanabe N, Takahashi S, Iwamoto A, Koseki H, Nakanishi M, Eto K, Nakauchi H.
Division of Stem Cell Therapy, Center for Stem Cell Biology and Regenerative Medicine, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.

The temporal pattern of stimulation determines the extent and duration of MAPK activation in a Caenorhabditis elegans sensory neuron

Sci Signal. 2012 Oct 16;5(246):ra76. doi: 10.1126/scisignal.2002983.
Tomida T, Oda S, Takekawa M, Iino Y, Saito H.
1Division of Molecular Cell Signaling, Institute of Medical Science, University of Tokyo

The Receptor LMIR3 Negatively Regulates Mast Cell Activation and Allergic Responses by Binding to Extracellular Ceramide

Immunity 2012 Oct 30. pii: S1074-7613(12)00458-X. doi: 10.1016/j.immuni.2012.08.018
Izawa K, Yamanishi Y, Maehara A, Takahashi M, Isobe M, Ito S, Kaitani A, Matsukawa T, Matsuoka T, Nakahara F, Oki T, Kiyonari H, Abe T, Okumura K, Kitamura T, Kitaura J.
Division of Cellular Therapy, Advanced Clinical Research Center, The Institute of Medical Science, The University of Tokyo, Department of Immunology, Juntendo University School of Medicine

Next-generation sequencing coupled with a cell-free display technology for high-throughput production of reliable interactome data

Scientific Reports 2, 691 doi:10.1038/srep00691
Shigeo Fujimori, Naoya Hirai, Hiroyuki Ohashi, Kazuyo Masuoka, Akihiko Nishikimi, Yoshinori Fukui, Takanori Washio, Tomohiro Oshikubo, Tatsuhiro Yamashita, Etsuko Miyamoto-Sato
Division of Interactome Medical Sciences, The Institute of Medical Science, The University of Tokyo, Division of Immunogenetics, Department of Immunobiology and Neuroscience, Medical Institute of Bioregulation, Kyushu University, RIKEN GENESIS Co., Ltd., Production Solution Business Office, Production Solution Division II, Solution Department I, Fujitsu Advanced Engineering Limited, BioIT Business Development Unit, Fujitsu Limited, Human Genome Center, The Institute of Medical Science, The University of Tokyo.

p47 negatively regulates IKK activation by inducing the lysosomal degradation of polyubiquitinated NEMO

Nature Communications 3:1061 doi:10.1038/ncomms2068 (2012)
Shibata Y, Oyama M, Kozuka-Hata H, Han X, Tanaka Y, Gohda J, Inoue J.
Department of Cancer Biology, Division of Cellular and Molecular Biology, Institute of Medical Science, University of Tokyo, Shirokane-dai, Minato-ku, Tokyo 108-8639, Japan.

Network Analysis of the Focal Adhesion to Invadopodia Transition Identifies a PI3K-PKCα Invasive Signaling Axis

Science Signaling vol 5, issue 241, p.ra66 (11 Sep. 2012)
Daisuke Hoshino1, Jerome Jourquin2, Shane Weller Emmons2, Tyne Miller2, Margalit Goldgof2, Kaitlin Costello2, Darren R. Tyson2, Brandee Brown2, Yiling Lu3, Nagendra K. Prasad4, Bing Zhang2, Gordon B. Mills2, Wendell G. Yarbrough2, Vito Quaranta2, Motoharu Seiki1, and Alissa M. Weaver2
1.Division of Cancer Cell Research, Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan, 2.Vanderbilt University School of Medicine, USA, 3.Department of Systems Biology, M. D. Anderson Cancer Center、USA, 4.Indiana University School of Medicine, USA

Extracellular ATP mediates mast cell-dependent intestinal inflammation through P2X7 purinoceptors

Nature communications DOI: 10.1038/ncomms2023
Yosuke Kurashima1,2,3, Takeaki Amiya1,3,4, Tomonori Nochi1, Kumiko Fujisawa1,3, Takeshi Haraguchi5, Hideo Iba5, Hiroko Tsutsui6, Shintaro Sato1,3, Sachiko Nakajima7, Hideki Iijima7, Masato Kubo8,9, Jun Kunisawa1,4 & Hiroshi Kiyono1,2,3,4
1 Division of Mucosal Immunology, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo, 108-8639, Japan. 2 Graduate School of Medicine, The University of Tokyo, 113-0033, Japan. 3 Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency (JST), Tokyo 102-0075, Japan. 4 Department of Medical Genome Science, Graduate School of Frontier Science, The University of Tokyo, Chiba 277-8561, Japan. 5 Division of Host-Parasite Interaction, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo, 108-8639, Japan. 6 Department of Microbiology, Hyogo College of Medicine, Nishinomiya 663-8501, Japan. 7 Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 565-0871, Japan. 8 Research Center for Allergy and Immunology, RIKEN, Yokohama Institute, Tsurumi, Yokohama, Kanagawa, 230-0045, Japan. 9 Division of Molecular Pathology, Research Institute for Biological Sciences, Tokyo University of Sciences, Chiba 278-0022, Japan.

Detection of the Heterogeneous O-Glycosylation Profile of MT1-MMP Expressed in Cancer Cells by a Simple MALDI-MS Method

PLoS ONE 7・8・e43751・2012
Takuya Shuo1, Naohiko Koshikawa1, Daisuke Hoshino1, Tomoko Minegishi1, Hiroko Ao-Kondo2, Masaaki Oyama2, Sadanori Sekiya3, Shinichi Iwamoto3, Koichi Tanaka3, Motoharu Seiki1
1: Division of Cancer Cell Research, Institute of Medical Science, 2: Medical Proteomics Laboratory, Institute of Medical Science, 3: Koichi Tanaka Mass Spectrometry Research Laboratory, Shimadzu Corporation

Possible ErbB-NF-κB pathways in breast cancer stem cells for tumorigenesis

Proceedings of National Academy of Science, USA doi: 10.1073/pnas.111327110
Kunihiko Hinohara1, Seiichiro Kobayashi2, Hajime Kanauchi3, Seiichiro Shimizu4, Kotoe Nishioka5, Ei-ichi Tsuji5, Kei-ichiro Tada5, Kazuo Umezawa6, Masaki Mori7, Toshihisa Ogawa5, Jun-ichiro Inoue8, Arinobu Tojo2 and Noriko Gotoh1
1 Division of Systems Biomedical Technology, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639; 2 Division of Molecular Therapy, Advanced Clinical Research Center, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639; 3 Department of Breast and Endocrine Surgery, Showa General Hospital, Kodaira-shi, Tokyo 187-8510; 4 Department of Pathological Diagnosis, Showa General Hospital, Kodaira-shi, Tokyo 187-8510; 5 Department of Breast and Endocrine Surgery, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo 113-8655; 6 Department of Applied Chemistry, Faculty of Science and Technology, Keio University, Yokohama-shi, Kanagawa 223-8522; 7 Department of Gastroenterological Surgery, Osaka University, Suita-shi, Osaka, 565-0871; 8 Division of Cellular and Molecular Biology, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639
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