The Institute of Medical Science, The University Of Tokyo

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Department of Microbiology and Immunology

Chair:Kensuke Miyake Organization/Researchers

The scope of our research in this department includes the elucidation of the molocular interactions between pathogens and the host that are necessary for the establishment of infectious diseases, molecular recognition of self and non-self by the immune system, and modulatory mechanisms of host defence systems. Understanding the molecular bases for such processes will be applied to the development of novel approaches for preventing or controlling infectious diseases and immune disorders. The department is composed of several groups working on bacterial infection, viral infection, host-parasite relationships, molecular and cellular immunology, mucosal immunity, compromised host genetics and developmental gene regulation. Although each research group has particular interests in either the pathogen or the host, their research is not limited to one or other of these biological systems. Rather, their research covers a wide range of dynamic interactions between microbes and the host in the development of infectious diseases and the distinction between self and non-self in inmmune systems. Our department has been successfully promoting basic research in the area of infection and immunity in collaboration with many other groups in this and other countries. In addition, we have actively engages in promoting collaborative projects with various groups in pharmaceutical companies and clinical laboratories for the development of drugs, vaccines and immunobiomaterials. The growing concern in emerging and reemerging infectious diseases demands further support of the basic research that we have developed in our department. Our department, as one of the pioneering groups in our country, strongly endeavours to promote and expand our research activity, our collaborations with other groups engaged in studies of infection and immunity, and the training and professional development of young independent investigators through studies in the department.

Division of Virology

Head:Yoshihiro Kawaoka | General Research Building 3F


Viruses can cause devastating diseases. The long-term goal of our research is to understand the molecular pathogenesis of viral diseases by using influenza and Ebola virus infections as models. Interactions between viral and host gene products during viral replication cycles determine the consequences of infection (i.e., the characteristics of disease manifestation, whether limited or widespread); hence, our research has centered on such interactions in these viral infections.

Professor

Yoshihiro Kawaoka

+81-3-5449-5310

Visiting Professor Takeshi Noda
Associate Professor Masaki Imai

+81-3-5449-5281

Project Associate Professor Tokiko Watanabe

+81-3-6409-2207

Project Associate Professor Seiya Yamayoshi

+81-3-5449-5502

Assistant Professor Kiyoko Iwatsuki

+81-3-6409-2207

Assistant Professor Shinya Yamada

+81-3-5449-5281

Project Assistant Professor Maki Kiso

+81-3-6409-2207

Project Assistant Professor Hiroshi Ueki

+81-3-5449-5281

Research Associate Yuko Sakai

+81-3-5449-5281

Division of Virology Website

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Division of Infectious Genetics

Head:Kensuke Miyake | Fourth Building 2F


Our division focuses on Toll-like receptors (TLRs), which sense pathogen components and activate defense responses. TLRs also respond to self-derived products and play pathogenic roles in autoimmune diseases. Our division is studying molecular mechanisms behind pathogen recognition by TLRs and pathogenic roles of TLRs in autoimmune diseases. We also try to develop a therapeutic targeting TLRs for the control of autoimmune diseases.

Professor

Kensuke Miyake

+81-3-5449-5290

Associate Professor Shin-Ichiroh Saitoh

+81-3-5449-5378

Assistant Professor Ryutaro Fukui

+81-3-5449-5378

Assistant Professor Takuma Shibata

Project Assistant Professor Ryota Sato

Division of Infectious Genetics Webiste

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Division of Molecular Virology

Head:Yasushi Kawaguchi | General Research Building 3F


In our laboratory, we are promoting strategic fundamental research aimed at developing a novel method of viral infection control by elucidating the mechanism underlying viral proliferation/pathology. Moreover, using viruses as a biological probe, we are also challenging next-generation virology to reconsider viruses as a homeostasis factor and explore their significance, in addition to unraveling cells and physiological control mechanisms that cannot be elucidated by research on normal human hosts.

Professor

Yasushi Kawaguchi

+81-3-6409-2070

Assistant Professor Akihisa Kato

+81-3-6409-2071

Assistant Professor Jun Arii

+81-3-6409-2071

Assistant Professor Naoto Koyanagi

+81-3-6409-2071

Project Assistant Professor Yuhei Maruzuru

+81-3-6409-2071

Division of Molecular Virology Website

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Division of Vaccine Science

Head:Ken Ishii


 

Professor

Ken Ishii

+81-3-5449-5314

Associate Professor Kouji Kobiyama  
Project Senior Assistant Professor Hideo Negishi  
Assistant Professor Temizoz Burcu  

Division of Vaccine Science Website

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Division of Malaria Immunology

Head:Cevayir Coban


 

Professor

Cevayir Coban

Division of Malaria Immunology Website

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