The Frontier Research Initiative is managed under the theme adopted by the University of Tokyo, "Promotion of Independence for Young Investigators" (representative: President Hiroshi Komiyama), funded by "Program for Improvement of Research Environment for Young Researchers" from the Ministry of Education, Culture, Sports, Science and Technology (MEXT). In cooperation with the university-wide program steering committee, the office of program supervision established within the Institute of Medical Science supports the research and training of mainly two Frontier Research Team Leaders and four Frontier Researchers. Various professors from within the Institute serve as mentors, offering guidance and advice on research and training matters.