The Institute of Medical Science, The University Of Tokyo

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Center for Experimental Medicine and Systems Biology

Director:Nobuaki Yoshida Organization/Researchers

More than 10,000 gene knockout (KO) mouse lines have already been produced in the world, and approximately 4,000 gene functions were analyzed, but still the functions of more than 20,000 genes remain to be elucidated. Because generation of gene knockout mice is one of the most efficient ways, or sometimes the only way, to analyze the function of a particular gene, USA, Canada and European countries have already started the projects to generate KO mice of all the genes. Probably, almost all the gene functions will be unraveled untill 2018. Therefore, it is urgent to accelerate the research in this field in Japan.

To accelerate this research, we have reorganized the Center for Experimental Medicine and establish a new research center, the Center for Experimental Medicine and Systems Biology (CEMSB) in 2009. In this center, we analyze the gene functions of disease-related genes by generating gene KO mice. The CEMSB mainly analyze the function of tumor- and immune disorder-related genes. Importantly, the roles of individual genes in the development of a particular disease and the relationship among these genes are systematically analyzed in living animals, making it possible to simulate the development of diseases in the computer.

Four laboratories form the core of the CEMSB: the Division of Disease Models, Molecular Pathogenesis, Molecular Genetics, and Systems Biology. The Laboratory of Innate Immunity and Laboratory of Tumor Biology join the center as collaborating laboratories in the IMSUT. The laboratories of two visiting professors also join in collaboration with Kumamoto and Osaka Universities.

Laboratory of Developmental Genetics

Head:Nobuaki Yoshida | General Research Building 1F


 

Professor

Nobuaki Yoshida

+81-3-5449-5753

Associate Professor Hirotake Ichise 

Assistant Professor Taeko Ichise 

+81-3-5449-5754

Assistant Professor Manabu Ozawa

+81-3-5449-5754

Laboratory of Developmental Genetics Website

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Laboratory of Innate Immunity

Head: Kensuke Miyake


 

Professor

Kensuke Miyake

Laboratory of Innate Immunity Website

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Laboratory of Systems Biology

Head: Susumu Nakae|Third Building 3F


 

Associate Professor

Susumu Nakae

+81-3-6409-2111

Laboratory of Systems Biology Website

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Laboratory of Genetically Engineered Mouse Research

Head: Kimi Araki


 

Professor

Kimi Araki

Laboratory of Genetically Engineered Mouse Research Website

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Laboratory of Reproductive Systems Biology

Head: Masahito Ikawa


 

Professor (Project)

Masahito Ikawa

Laboratory of Reproductive Systems Biology Website

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Laboratory of Advanced Molecular Genetics

Head:Kosuke Yusa


 

Visiting Professor

Kosuke Yusa

Laboratory of Advanced Molecular Genetics Website

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