The Institute of Medical Science, The University Of Tokyo

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Laboratory Animal Research Center

Director:Tomoji Mashimo Organization/Researchers
 

Division of Animal Genetics

Head:Tomoji Mashimo | General Research Building 2F


Genome engineering technologies, such as Zinc finger nucleases (ZFNs), TAL effector nucleases (TALENs), and clustered regularly interspaced short palindromic repeats (CRISPR)-associated (Cas) nucleases (CRISPR/Cas), achieve a "revolution" in life science and medical science. These techniques allow us to manipulate genes of interest for several purposes. Using those technologies, we are focusing on generating "humanized animals" or "immunodeficient animals". These valuable animals can be used for xenotransplantation of human cells/tissues including human iPS cells.

Professor

Tomoji Mashimo

+81-3-6409-2228

Senior Assistant Professor Kazuto Yoshimi

+81-3-6409-2489

Division of Animal Genetics Website

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Animal Center

Head:Tomoji Mashimo | Animal Center


The Laboratory Animal Research Center (LARC) was founded in 1965 as the first modern animal facility in Japan. The mice are strictly maintained in the SPF condition. The Animal Center building was improved to perform genome engineering in animals, to make infectious experiments (P2A, P3A), and to house bigger animals, such as rats and rabbits. Techniques of mouse embryo manipulation and generating genetically modified mice, including genome editing technologies, have been introduced into the LARC.

Professor

Tomoji Mashimo

+81-3-5449-5532

Laboratory Animal Research Center Website

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