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Advanced Clinical Research Center

Director:Toshio Kitamura Organization/Researchers

The Advanced Clinical Research Center achieves the purpose-oriented research that bridges basic science to clinical medicine by the collaboration with IMSUT Basic Research Activities, Human Genome Center, and Animal Center for Experimental Human Disease. The Center consists of five Divisions of Molecular Therapy, Infectious Diseases, Bioengineering, and Immunological Pathology, and three Donated Laboratories of Divisions of Cell Processing (ASAHI CHEMICAL NISSHO Co.), Hematopoietic Factors (CHUGAI), and Genetic Diagnosis(OTSUKA). Our research projects are to innovate clinical technology utilizing basic information newly obtained from basic research of Genomics and Regenerative Science. Simultaneously, the Center proposes definite plans of translational research and actively gets involved in achieving the clinical studies performed in the Research Hospital. Our diagnostic and therapeutic technologies which we should promote will be changed from time to time. Currently, our Center has been involved in the developmental researches of new cell and gene therapies targetting immuno-hematological disorders, AIDS and solid tumors.

Division of Molecular Therapy

Head:Arinobu Tojo | General Research Building 4F


 

Professor

Arinobu Tojo

+81-3-5449-5540

Associate Professor Satoshi Takahashi  
Visiting Associate Professor Hiroaki Taniguchi  
Assistant Professor Muneyoshi Futami  
Assistant Professor (Hospital) Seiko Kato  
Assistant Professor (Hospital) Takaaki Konuma  
Assistant Professor (Hospital) Toyotaka Kawamata  
Assistant Professor Masamichi Isobe

Division of Molecular Therapy Website
Molecular Targets Laboratory, Division of Molecular Therapy Website

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Division of Cellular Therapy

Head:Toshio Kitamura | General Research Building 5F


We are mainly committed to basic studies on hematopoietic tumor, normal hematopoiesis and leukemic stem cells. Current efforts focus on elucidating the fundamental role of epigenetic alteration in hematopoietic malignancies, developing new treatment strategies with mouse models of hematopoietic tumor, and unraveling the detailed molecular mechanism of hematopoietic stem cell replication and differentiation. We also challenge the development of novel experimental tools, such as G0 marker mouse and cell cycle counter.

Professor

Toshio Kitamura

+81-3-5449-5758

Associate Professor Susumu Goyama

+81-3-5449-5782

Assistant Professor Tomofusa Fukuyama

+81-3-5449-5632

Assistant Professor Yosuke Tanaka

+81-3-5449-5632

Division of Cellular Therapy Website

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Division of Infectious Diseases

Head:Hiroshi Yotsuyanagi | First Building 3F


 

Professor

Hiroshi Yotsuyanagi

Associate Professor Takeya Tsutsumi
Assistant Professor Michiko Koga
Assistant Professor Makoto Saito

Division of Infectious Diseases Website

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Division of Clinical Genome Research

Head:Yoichi Furukawa | Third Building 4F


Through the analysis of molecules associated with cancer, we have been investigating the precise mechanisms of human carcinogenesis. Additionally, we are working on the implementation of genomic information to precision medicine, and are challenging for the development of anticancer drugs targeting novel molecular target(s) and the identification of novel biomarkers.

Professor

Yoichi Furukawa

+81-3-6409-2100/FAX:+81-3-6409-2103

Associate Professor Tsuneo Ikenoue

+81-3-6409-2105

Project Senior Assistant Professor Kiyoshi Yamaguchi

+81-3-6409-2106

Assistant Professor Kiyoko Takane

+81-3-6409-2106

Division of Clinical Genome Research Website

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Division of Innovative Cancer Therapy

Head:Tomoki Todo | Second Building 4F


We have been focusing on the development of innovative cancer treatment, especially with genetically-engineered viruses which can kill the tumor cells without affecting normal cells. G47Δ, a triple-mutated herpes simplex virus type I (HSV-1), exhibits potent therapeutic efficacy with enhanced safety. G47Δ has been used in several clinical trials that are ongoing. We are also seeking next generation therapeutics utilizng G47Δ and patient-derived glioma cell lines to overcome resistance, recurrence and metastasis often seen in the clinical settings.

Professor

Tomoki Todo

+81-3-6409-2145

Project Associate Professor Minoru Tanaka

+81-3-6409-2145

Assistant Professor(Hospital) Seisaku Kanayama

+81-3-6409-2145

Assistant Professor Chalise Lushun

+81-3-6409-2145

Assistant Professor Yoshinori Sakata

+81-3-6409-2145

Assistant Professor Hirotaka Ito

+81-3-6409-2145

Division of Innovative Cancer Therapy Website

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Division of Advanced Medicine Promotion

Head:Fumitaka Nagamura | First Building 1F


In order to promote translational research that applies the results of basic research to clinical application, we conduct regulatory science and researches from the viewpoint of biostatistics and data management. We actively involve in new modalities, and actively promote the development of seeds not only in IMSUT, but from other institutes. Our works are closely related to Center for Translational Research of IMSUT Hospital.

Professor

Fumitaka Nagamura

+81-3-6409-2422

Associate Professor Masanori Nojima

+81-3-6409-2340

Division of Advanced Medicine Promotion Website

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Division of Advanced Genome Medicine

Head:Yoshihiro Hirata | Research Building (Annex) 1F


The goals of our researches are to identify the mechanisms and to establish novel therapies especially for cancers and inflammatory diseases of the digestive system. One of the research fields is the inflammatory diseases, in which we investigated the molecular pathogenesis of gastritis, cholangitis and inflammatory bowel disease. Another research field is the malignancies. Using genetically engineered mice, we try to unvail the carcinogenic mechanisms driven by gene mutations.

Associate Professor

Yoshihiro Hirata

+81-3-6409-2337

Senior Assistant Professor Yasuo Matsubara

Division of Advanced Genome Medicine Website

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Division of Bioethics

Head:Ayako Kamisato | First Building 3F


 

Associate Professor

Ayako Kamisato

+81-3-6409-2035

Division of Bioethics Website

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Partnership

IMSUT Hospital

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