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Investigation of mechanisms underlying human gastrointestinal cancer  
     
 
Development and progression of human cancer involves not only genetic changes including amplifications, losses, and point mutations of genes, but also deregulated gene expression. To develop novel strategies for treatment, diagnosis, and prevention of human cancer, we searched for molecules associated with carcinogenesis by the following approaches.

1. We carried out global gene expression profile analysis and identified a set of genes whose expression is elevated in human tumors. Among these genes, we focused on genes that are essential for the growth or survival of tumor cells. To develop molecular-targeted anticancer drugs, we have been investigating the function of selected genes and trying to establish systems of selecting their inhibitors.

2. We are analyzing function of molecules associated with signal transduction pathways, such as Wnt and Notch, which are activated in cancer. These studies are expected to clarify regulatory systems of the pathways, and helpful for the development of novel anticancer drugs.

3. We fond that deregulated expression of SMYD3, a histone methyltransferase, plays a role in human carcinogenesis. We are studying how abrogation of histone modification enzymes is involved in the development and progression of human tumors.

 
     
     
@ II. Application of genome information for clinics  
     
 

Human cancer has different sensitivity to anticancer drugs. Therefore, it is necessary to use the most suitable drug(s) according to the patient's susceptibility to the drug(s) and tumor's biological character, namely personalized medicine. We previously generated systems to predict sensitivity of anticancer drugs using gene expression profiles of human tumors. We are now performing prospective studies to evaluate efficacy of the systems.

 
     
@III.
Genetic testing project for Hereditary non-polyposis colorectal cancer(HNPCC)  
     
 
HNPCC is an autosomal dominant hereditary disease accompanied by tumors arising mainly in the colon and other associated organs. We are doing this project in collaboration with the Japanese Society for Cancer of the Colon and Rectum. This project aims to clarify clinical and genetic characteristics of HNPCC, and to provide patients and their relatives with more useful information of this disease.
 
     
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Investigation of mechanisms underlying human gastrointestinal cancer

Application of genome information for clinics

Genetic testing project for Hereditary non-polyposis colorectal cancer (HNPCC)

Microarray Data