Arimoto-Matsuzaki K, Saito H and Takekawa M.

TIA1 oxidation inhibits stress granule assembly and sensitizes cells to stress-induced apoptosis.

Nature Commun. 7: 10252 doi:10.1038/ncomms10252 (2016)

Hijiya N, Tsukamoto Y, Nakada C, Tung NL, Kai T, Matsuura K, Shibata K, Inomata M, Uchida T, Tokunaga A, Amada K, Shirao K, Yamada Y, Mori H, Takeuchi I, Seto M, Aoki M, Takekawa M, and Moriyama M.    Genomic loss of DUSP4 contributes to the progression of intraepitherial neoplasm of pancreas to invasive carcinoma.

Cancer Res. 76: 2612-2625 (2016)

Kinoshita E, Kinoshita-Kikuta E, Kubota Y, Takekawa M and Koike T.

A Phos-tag SDS-PAGE method that effectively uses phosphoproteomic data for profiling the phosphorylation dynamics of MEK1.

Proteomics 16: 1825-1836 (2016)

Kubota Y and Takekawa M. 

Detection and functional analysis of SUMO-modified MEK. 

Methods in Molecular Biology, Springer Press, in press (2016)

Ichikawa K, Kubota Y, Nakamura T, Weng JS, Tomida T, Saito H and Takekawa M.

MCRIP1, an ERK substrate, mediates ERK-induced gene silencing during epithelial-mesenchymal transition by regulating the co-repressor CtBP.

Molecular Cell 58: 35-46 (2015) [Abstract]  [Faculty of 1000]

Tomida T, Takekawa M and Saito H.

Oscillation of p38 activity controls efficient pro-inflammatory gene expression.

Nature Commun. 6: 8350 doi:10.1038/ncomms9350 (2015)

Ohshima D, Arimoto-Matsuzaki K, Tomida T, Takekawa M and Ichikawa K.

Spatio-temporal dynamics and mechanisms of stress-granule assembly.

PLoS Comput. Biol. 11: e1004326 doi:10.1371/journal.pcbi.1004326 (2015)

Takekawa M and Kubota Y. 

Mitogen-activated protein kinase signaling and cancer. 

Protein Modifications in Pathogenic Dysregulation of Signaling, Springer Press, 211-231 (2015)

Ohshima D, Arimoto-Matsuzaki K, Tomida T, Takekawa M and Ichikawa K. 

Stochastic Simulation of Stress Granules. 

Protein Modifications in Pathogenic Dysregulation of Signaling, Springer Press, 77-93 (2015)

Sato Y, Goto E, Shibata Y, Kubota Y, Yamagata A, Goto-Ito S, Kubota K, Inoue J, Takekawa M, Tokunaga F, Fukai S.

Structures of CYLD USP with Met1- or Lys63-linked diubiquitin reveal mechanisms for dual specificity.

Nature Struct. & Mol. Biol. 22: 222-229 (2014)

Nakamura T, Saito H and Takekawa M.

SAPK pathways and p53 cooperatively regulate PLK4 activity and centrosome integrity under stress.

Nature Commun. 4:1775 doi:10.1038/ncomms2752 (2013)

Tomida T, Osa S, Takekawa M, Iino Y and Saito H.

The temporal pattern of stimulation determines the extent and duration of MAPK activation in a caenorhabditis elegans sensory neuron.

Science Signaling 5, ra76 (2012)

Kubota Y, O’Grady P, Saito H and Takekawa M.

Oncogenic Ras abrogates MEK SUMOylation that suppresses the ERK pathway and cell transformation.

Nature Cell Biol13, 282-291 (2011)  [Abstract]  [Faculty of 1000]

   紹介記事 LinkEditor’s Choice ” in  Science Signaling / Highlights in A-IMBN Research 他

Otsuka M, Takata A, Yoshikawa T, Kojima K, Kishikawa T, Shibata C, Takekawa M, Yoshida H, Omata M, and Koike K.

Receptor for activated protein kinase C: Requirement for efficient microRNA function and reduced expression in hepatocellular carcinoma.

PLoS ONE 6, e24359 (2011)


Takekawa M, Kubota Y, Nakamura T and Ichikawa K.

Regulation of stress-activated MAP kinase pathways during cell fate decisions. (review)

Nagoya J. Med. Sci. 73, 1-14 (2010)

Tomida T, Takekawa M, O’Grady P and Saito H.

Stimulus-specific distinctions in spatial and temporal dynamics of stress-activated protein kinase kinase kinases revealed by FRET biosensor.

Mol. Cell. Biol. 29, 6117-6127 (2009)

Arimoto K, Fukuda H, Imajoh-Ohmi S, Saito H, and Takekawa M.

Formation of stress granules inhibits apoptosis by suppressing stress-responsive MAPK pathways.

Nature Cell Biol. 10, 1324-1332 (2008)

     紹介記事 LinkEditor’s Choice ” in  Science / Science Signaling / Nature Signaling Gateway


Miyake Z, Takekawa M, Ge Q and Saito H.

Activation of MTK1/MEKK4 by GADD45 through induced N-C dissociation and dimerization-mediated trans-autophosphorylation of the MTK1 kinase domain.

Mol. Cell. Biol. 27, 2765-2776 (2007)


Nakajima A, Komazawa-Sakon S, Takekawa M, Sasazuki T, Yeh W-C, Yagita H, Okumura K and Nakano H.

An antiapoptotic protein, c-FLIPL, directly binds to MKK7 and inhibits the JNK pathway.

EMBO J. 25, 5549–5559 (2006)


Fujimoto H, Onishi N, Kato N, Takekawa M, Xu X-Z, Kosugi A, Kondo T, Imamura M, Yoda A, Oishi I, and Minami Y.

Regulation of the anti-oncogenic Chk2 kinase by the oncogenic Wip1 phosphatase.

Cell Death Differ. 13, 1170-1180 (2006)


Takekawa, M., Tatebayashi, K., and Saito, H. 

Conserved docking site is essential for activation of mammalian MAP kinase kinases by specific MAP kinase kinase kinases.

Molecular Cell 18, 295-306 (2005)


Chi H, Lu B, Takekawa M, Davis RJ, and Flavell RA.

GADD45β/GADD45γ and MEKK4 comprise a genetic pathway mediating STAT-independent IFNγ production in T cells.

EMBO J. 23, 1576–1586 (2004)

Takagaki K, Satoh T, Tanuma N, Masuda K, Takekawa M, Shima H and Kikuchi K. 

Characterization of a novel low-molecular-mass dual-specificity phosphatase 3 (LDP-3) that enhances activation of JNK and p38.

Biochemical J. 383, 447-455 (2004)


Sakon S, Xue X, Takekawa M, Sasazuki T, Okazaki T, Kojima Y, Pia J-H, Yagita H, Okumura K, Doi T and Nakano H.

NF-κB inhibits TNF-induced accumulation of ROS that mediate prolonged MAPK activation and necrotic cell death.

EMBO J. 22, 3898-3909 (2003)


Tatebayashi K, Takekawa M and Saito H.

A docking site determining specificity of Pbs2 MAPKK to Ssk2/Ssk22 MAPKKKs in yeast HOG pathway.

EMBO J. 22, 3624-3634, (2003)


Mitsuhashi S, Shima H, Tanuma N, Matsuura N, Takekawa M, Urano T, Kataoka T, Ubukata M and Kikuchi K.  Usage of tautomycetin, a novel inhibitor of protein phosphatase 1 (PP1) reveals that PP1 is a positive regulator of Raf-1 in COS-7 cells.

J. Biol. Chem. 278, 82-88, (2003)


Takekawa M, Tatebayashi K, Itoh F, Adachi M, Imai K and Saito H.

Smad-dependent GADD45β expression mediates delayed activation of p38 MAP kinase by TGF-β.

EMBO J. 21, 6473-6482 (2002) Full-scan画像

Mita H, Tsutsui J, Takekawa M, Witten EA and Saito H.

Regulation of MTK1/MEKK4 kinase activity by its N-terminal autoinhibitory domain and GADD45 binding.

Mol. Cell. Biol. 22, 4544-4555, (2002)


Shonai T, Adachi M, Sakata K, Takekawa M, Endo T, Imai K and Hareyama M.

MEK/ERK pathway protects ionizing radiation-induced loss of mitochondrial membrane potential and cell death in lymphocytic leukemia cells.

Cell Death Differ. 9, 963-971, (2002)


Itoh M, Adachi M, Yasui H, Takekawa M, Tanaka H and Imai K.

Nuclear export of glucocorticoid receptor is enhanced by JNK-mediated phosphorylation.

Mol. Endocrinol. 16, 2382-2392, (2002)

Matsunaga T, Ishida T, Takekawa M, Nishimura S, Adachi M and Imai K.

Analysis of gene expression during maturation of immature dendritic cells derived from peripheral blood monocytes.

Scand. J. Immunol. 56, 593-601, (2002)


Nakamura K, Tanoue K, Satoh T, Takekawa M, Watanabe M, Shima H and Kikuchi K. 

A novel low-molecular-mass dual-specificity phosphatase, LDP-2, with a naturally occurred substitution that affects substrate specificity.

J. Biochem. 132, 463-470 (2002)


Takekawa M, Adachi M, Nakahata A, Nakayama I, Itoh F, Tsukuda H, Taya Y and Imai K.

p53-inducible Wip1 phosphatase mediates a negative feedback regulation of p38 MAPK-p53 signaling in response to UV radiation.

EMBO J., 19, 6517-6526, (2000)


Koyama Y, Adachi M, Sekiya M, Takekawa M and Imai K. 

Histone deacetylase inhibitors suppress IL-2-mediated gene expression prior to induction of apoptosis.

Blood 96, 1490-1495, (2000)

Kaneki M, Kharbanda S, Pandey P, Yoshida K, Takekawa M, Liou J-R, Stone R and Kufe D.

Functional role for protein kinase Cβ as a regulator of stress-activated protein kinase activation and monocytic differentiation of myeloid leukemia cells. 

Mol. Cell. Biol. 19, 461-470, (1999)


Takekawa M and Saito H. 

A family of stress-inducible GADD45-like proteins mediate activation of the stress-responsive MTK1/MEKK4 MAPKKK.

Cell  95, 521-530, (1998)


Takekawa M, Maeda T and Saito H. 

Protein phosphatase 2Cα inhibits the human stress-responsive p38 and JNK MAPK pathways. 

EMBO J. 17, 4744-4752, (1998)


Posas F, Takekawa M and Saito H. 

Signal transduction by MAP kinase cascades in budding yeast. 

Curr. Opin. Microbiol. 1, 175-182, (1998)

Takekawa M, Posas F and Saito H. 

A human homolog of the yeast Ssk2/Ssk22 MAP kinase kinase kinase, MTK1, mediates stress-induced activation of the p38 and JNK pathways. 

EMBO J. 16, 4973-4982, (1997)


Maeda T, Takekawa M and Saito H. 

Activation of yeast PBS2 MAPKK by MAPKKKs or by binding of an SH3-containing osmosensor. 

Science  269, 554-558, (1995)


Takekawa M, Itoh F, Hinoda Y, Adachi M, Ariyama T, Inazawa J, Imai K and Yachi A.  

Chromosomal localization of protein tyrosine phosphatase G1 gene and characterization of aberrant transcripts in human colon cancer cells.

FEBS Lett. 339, 222-228, (1994)


Adachi M, Maeda K, Takekawa M, Hinoda Y, Imai K, Sugiyama S and Yachi A.

High expression of CD56 (N-CAM) in a patient with cutaneous CD4-positive lymphoma. 

Am. J. Hematol. 47, 278-282, (1994)


Adachi M, Sekiya M, Arimura Y, Takekawa M, Itoh F, Hinoda Y, Imai K and Yachi A. 

Protein-tyrosine phosphatase expression in pre-B cell NALM-6.

Cancer Res. 52, 737-740, (1992)


Takekawa M, Itoh F, Hinoda Y, Arimura Y, Toyota M, Sekiya M, Adachi M, Imai K and Yachi A. 

Cloning and characterization of a human cDNA encoding a novel putative cytoplasmic protein tyrosine phosphatase.

Biochem. Biophys. Res. Commun. 189, 1223-1230, (1992)


Arimura Y, Hinoda Y, Itoh F, Takekawa M, Tsujisaki M, Adachi M, Imai K and Yachi A.

cDNA cloning of new protein-tyrosine-phosphatases in human colon. 

Tumor Biol. 13, 180-186, (1992)


Takekawa M, Imai K, Adachi M, Aoki S, Maeda K, Hinoda Y and Yachi A.

Hypereosinophilic syndrome accompanied with necrosis of finger tips.

Internal Med. 31, 1262-1266, (1992)






文部科学省/日本学術振興会 科研費NEWS 2017年度 Vol.1 p18 (2017).



実験医学 34巻16号 2752 (2016).



生物物理化学 電気泳動 60巻 7-10 (2016).



生物物理化学 電気泳動 60巻 s24 (2016).

久保田裕二, 松崎(有本)京子, 武川睦寛


医学のあゆみ 「特集:ストレスシグナルと疾患ー細胞恒常性維持機構の破綻と病態」

254巻5号 409-415 (2015).



生化学 86巻 666-670 (2014).

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放射線生物学 49巻3号 248-262 (2014).

久保田祐二, 武川睦寛


生物物理化学 57巻 s21(2013).

久保田祐二, 武川睦寛


Clinical Neuroscience 特集「神経系のMAPキナーゼ」31巻 657-660 (2013).

中村貴紀, 武川睦寛


日本臨床増刊号「分子標的薬:がんから他疾患までの治癒をめざして」 70巻 218-224 (2012).

中村貴紀, 武川睦寛


Medical Science Digest「特集:分子標的薬」 38巻 14-17 (2012).

久保田祐二, 中亮介, 武川睦寛


実験医学増刊「シグナル伝達研究最前線2012ー翻訳後修飾,解析技術,疾患との連関から創薬応用までー」30巻 72-79 (2012).



生物物理化学 56巻 s85 (2012)

武川睦寛, 久保田裕二


ライフサイエンス 新着論文レビューオンラインジャーナル(2011)



実験医学増刊「秒進分歩する癌研究と分子標的治療」29巻2号 125-131 (2011)



ー 細胞はどの様にして環境ストレス刺激を細胞内シグナルへと変換するか ー

宇宙環境利用に関する公募地上研究ニュース Vol. 8 (2007)



日本アルコール・薬物医学会雑誌 40巻4号  (2005)

武川睦寛, 舘林和夫, 斎藤春雄


蛋白質・核酸・酵素「MAPキナーゼ研究 現状と展望」47巻11号 1379-1389 (2002)


中山一郎, 武川睦寛, 小関至, 築田浩幸, 佐々木茂, 今井浩三


日本分子腫瘍マーカー研究会誌 Vol. 18: 41-42 (2002)


武川睦寛, 斎藤春雄


実験医学増刊「p53研究の新たな挑戦」19巻9号 1074-1079 (2001)


佐々木茂, 小関至, 中山一郎, 武川睦寛, 石田禎夫, 辻崎正幸, 今井浩三


臨床免疫 35巻3号 371-376 (2001)


小畑俊郎, 佐藤亜由美, 南貴恵, 水越常徳, 村上里絵子, 山本博幸, 武川睦寛, 菅谷壽晃, 高橋裕樹, 今井浩三


日本内科学会雑誌90巻12号 2475-2476 (2001)


小関至, 佐々木茂, 武川睦寛, 中山一郎, 三原真美, 安達靖代, 岩田徳和, 金戸宏行, 石田禎夫, 伊東文生, 辻崎正幸, 今井浩三


消化器と免疫 37号 24-27 (2001)


田賀理子, 高橋裕樹, 安井寛, 築田浩幸, 武川睦寛, 本谷聡, 菅谷壽晃, 曽根昭子, 鈴木純一, 池田建, 今井浩三


日本臨床免疫学会会誌 24巻3号 125-132 (2001)


高橋裕樹, 高橋大賀, 山崎健太郎, 安井寛, 小畑俊郎, 築田浩幸, 武川睦寛, 菅谷壽晃, 田中克典, 星秀樹, 今井浩三


リウマチ科 25巻5号 457-462 (2001)


山崎健太郎, 高橋裕樹, 田賀理子, 仲地耕平, 上野敦盛, 阿部環, 小畑俊郎, 水越常徳, 武川睦寛, 菅谷壽晃, 牧口祐介, 今井浩三


リウマチ 40巻6号 904-909 (2001)


武川睦寛, 今井浩三


イラスト医学&サイエンスシリーズ「細胞内シグナル伝達がわかる」(羊土社)20-27 (2000)


佐々木茂, 武川睦寛, 小関至, 金戸宏行, 岩田徳和, 石田禎夫, 辻崎正幸, 今井浩三


Biotherapy 14巻5号 490-492 (2000)


佐々木茂, 小関至, 武川睦寛, 辻崎正幸, 今井浩三

新しい免疫の啓蟄 外科学とのかかわり 癌の抗体治療

日本外科学会雑誌 101巻9号 607-611 (2000)


斎藤春雄, 武川睦寛


生物物理化学 43巻2号 49-55 (1999)


高岡朝子, 伊東文生, 垣内英樹, 武川睦寛, 有村佳昭, 生田茂夫, 日野田裕治, 今井浩三

大腸癌におけるprotein tyrosine phosphatasesの発現検討

腫瘍マーカー研究会誌 12巻, 73-75 (1998)


高岡晃教, 垣内英樹, 伊東文生, 有村佳昭, 武川睦寛, 日野田裕治, 今井浩三.

大腸癌におけるprotein tyrosine phosphatasesの発現検討.

消化器癌 6, 123-129 (1996)


中村英明, 淡川照仁, 山本博幸, 武川睦寛, 今井浩三, 笠井美智子, 川原田信, 佐藤保則.


薬理と臨床 23, 265-273 (1995)


武川睦寛, 今井浩三


血液・腫瘍科 29巻1号 35-44 (1994)


武川睦寛, 今井浩三, 谷内昭


病態生理 11巻6号 432-438 (1992)