主な業績

研究室の主な業績:1998-2014年に発表した約210論文より抜粋(reviewを除く)。
筆頭著者あるいはco-first author*が
・大学院生または学位論文の場合は二重下線
・博士研究員の場合は太字
・スタッフの場合は下線
で記載されています。



2015

Inoue D, Nishimura K, Kozuka-Hata H, Oyama M, Kitamura T. The stability of epigenetic factor ASXL1 is regulated through ubiquitination and USP7-mediated deubiquitination. Leukemia. in press


Matsukawa T, Izawa K, Isobe M, Takahashi M, Maehara A, Yamanishi Y, Kaitani A, Okumura K, Teshima T, Kitamura T, Kitaura J. Ceramide-CD300f binding suppresses experimental colitis by inhibiting ATP-mediated mast cell activation. Gut. 2015 Feb 11. Epub ahead of print pubmed journal


Togami K, Kitaura J, Uchida T, Inoue D, Nishimura K, Kawabata KC, Nagase R, Horikawa S, Izawa K, Fukuyama T, Nakahara F, Oki T, Harada Y, Harada H, Aburatani H, Kitamura T. A C-terminal mutant of CCAAT-enhancer-binding protein α (C/EBPα-Cm) downregulates Csf1r, a potent accelerator in the progression of acute myeloid leukemia with C/EBPα-Cm. Exp Hematol. 43(4):300-8 pubmed


Inoue D, Kitaura J, Matsui H, Hou H-A, Chou W-C, Nagamachi A, Kawabata KC, Togami K, Nagase R, Horikawa S, Saika M, Micol J-P, Hayashi Y, Harada Y, Harada H, Inaba T, Tien H-F, Abdel-Wahab O, Kitamura T SETBP1 mutations drive leukemic transformation in ASXL1-murtated MDS. Leukemia. 29:847-857.


Kitamura T, Inoue D, Okochi-Watanabe N, Kato N, Komeno Y, Lu Y, Enomoto Y, Doki N, Uchida T, Kagiyama Y, Togami K, Kawabata KC, Nagase R, Horikawa S, Hayashi Y, Saika M, Fukuyama T, Izawa K, Oki T, Nakahara F, Kitaura J. The molecular basis of myeloid malignancies. Proc Jpn Acad Ser B Phys Biol Sci. 90(10):389-404.


Miyadera H, Ohashi J, Lernmark A, Kitamura T, Tokunaga K Autoimmune susceptible HLA alleles encode unstable proteins. J. Clin. Invest. 125:275-291.




2014

Izawa K, Isobe M, Matsukawa T, Ito S, Maehara A, Takahashi M, Yamanishi Y, Kaitani A, Oki T, Okumura K, Kitamura T, Kitaura J. Sphingomyelin and ceramide are physiological ligands for human LMIR3/CD300f, inhibiting FcεRI-mediated mast-cell activation. J Allergy Clin Immunol. 133(1):270-3.e1-7. pubmed journal


Uchida T, Kitaura J, Nakahara F, Togami K, Inoue D, Maehara A, Nishimura K, Kawabata KC, Doki N, Kakihana K, Yoshioka K, Izawa K, Oki T, Sada A, Harada Y, Ohashi K, Katayama Y, Matsui T, Harada H, Kitamura T. Hes1 up-regulation contributes to the development of FIP1L1-PDGFRA-positive leukemia in blast crisis. Exp Hematol. 42(5):369-379. pubmed journal


Oki T, Nishimura K, Kitaura J, Togami K, Maehara A, Izawa K, Sakaue-Sawano A, Niida A, Miyano S, Aburatani H, Kiyonari H, Miyawaki A, Kitamura T. A novel cell-cycle-indicator, mVenus-p27K-, identifies quiescent cells and visualizes G0-G1 transition. Sci Rep. 4:4012. pubmed journal


Nakahara F, Kitaura J, Uchida T, Nishida C, Togami K, Inoue D, Matsukawa T, Kagiyama Y, Enomoto Y, Kawabata KC, Chen-Yi L, Komeno Y, Izawa K, Oki T, Nagae G, Harada Y, Harada H, Otsu M, Aburatani H, Heissig B, Hattori K, Kitamura T. Hes1 promotes blast crisis in chronic myelogenous leukemia through MMP-9 upregulation in leukemic cells. Blood. 123(25):3932-42. pubmed journal


Ishihara J, Umemoto T, Yamato M, Shiratsuchi Y, Takaki S, Petrich BG, Nakauchi H, Eto K, Kitamura T, Okano T. Nov/CCN3 regulates long-term repopulating activity of murine hematopoietic stem cells via integrin αvβ3. Int J Hematol. 2014 Apr;99(4):393-406. pubmed journal


Sashida G, Harada H, Matsui H, Oshima M, Yui M, Harada Y, Tanaka S, Mochizuki-Kashio M, Wang C, Saraya A, Muto T, Hayashi Y, Suzuki K, Nakajima H, Inaba T, Koseki H, Huang G, Kitamura T, Iwama A. Ezh2 loss promotes development of myelodysplastic syndrome but attenuates its predisposition to leukaemic transformation. Nat Commun. 2014 Jun 23;5:4177. pubmed journal




2013

Inoue D, Kitaura J, Togami K, Nishimura K, Enomoto Y, Uchida T, Kagiyama Y, Kawabata KC, Nakahara F, Izawa K, Oki T, Maehara A, Isobe M, Tsuchiya A, Harada Y, Harada H, Ochiya T, Aburatani H, Kimura H, Thol F, Heuser M, Levine RL, Abdel-Wahab O, and Kitamura T. Myelodysplastic syndromes are induced by histone methylation?altering ASXL1 mutations. J Clin Invest. 123(11):4627-40. pubmed journal


Nishimura K, Oki T, Kitaura J, Kuninaka S, Saya H, Sakaue-Sawano A, Miyawaki A, Kitamura T. APCCDH1 targets MgcRacGAP for destruction in the late M phase. PLOS One 8(5) pubmed journal


Harada Y*, Inoue D*, Ding Y*, Imagawa J, Doki N, Matsui H, Yahata T, Matsushita H, Ando K, Sashida G, Iwama A, Kitamura T, Harada H. Runx1/AML1 mutant collaborates with Bmi1 overexpression in the development of human and mouse myelodysplastic syndromes. Blood 121(17):3434-46. pubmed journal


Takahashi M, Izawa K, Kashiwakura J, Yamanishi Y, Enomoto Y, Kaitani A, Maehara A, Isobe M, Ito S, Matsukawa T, Nakahara F, Oki T, Kajikawa M, Ra C, Okayama Y, Kitamura T, Kitaura J. Human CD300C delivers an Fc receptor-g-dependent activating signal in mast cells and monocytes and differs from CD300A in ligand recognition. J. Biol. Chem. 288(11):7662-75. pubmed journal




2012

Izawa K, Yamanishi Y, Maehara A, Takahashi M, Isobe M, Ito S, Kaitani A, Matsukawa T, Matsuoka T, Nakahara F, Oki T, Kiyonari H, Abe T, Okumura K, Kitamura T, Kitaura J. LMIR3 negatively regulates mast cell activation and allergic responses by binding to extracellular ceramide. Immunity 37(5):827-39. pubmed journal


Kagiyama Y, Kitaura J, Togami K, Uchida T, Inoue D, Matsukawa T, Izawa K, Kawabata KC, Komeno Y, Oki T, Nakahara F, Sato K, Aburatani H, Kitamura T. Upregulation of CD200R1 in lineage-negative leukemic cells is characteristic of AML-ETO-positive leukemia in mice. Int. J. Hematol. 96(5):638-48. pubmed journal


Yamanishi Y, Takahashi M, Izawa K, Isobe M, Ito S, Tsuchiya A, Maehara A, Kaitani A, Uchida T, Togami K, Enomoto Y, Nakahara F, Oki T, Kajikawa M, Kurihara H, Kitamura T, Kitaura J. A soluble form of LMIR5/CD300b amplifies lipppolisaccharide-induced lethal inflammation in sepsis. J. Immunol. 189(4):1773-9. pubmed journal


Doki N, Kitaura J, Uchida T, Inoue D, Kagiyama Y, Togami K, Isobe M, Ito S, Maehara A, Izawa K, Kato N, Oki T, Harada Y, Nakahara F, Harada H, Kitamura T. Fyn is not essential for Bcr-Abl-induced leukemogenesis in mouse bone marrow transplantation models. Int. J. Hematol. 95(2):167-75. pubmed journal


Nakamura M, Kitaura J, Enomoto Y, Lu Y, Nishimura K, Isobe M, Ozaki K, Komeno Y, Nakahara F, Oki T, Kume H, Homma Y, Kitamura T. TSC-22 is a negative-feedback regulator of Ras/Raf signaling: Implications for tumorigenesis. Cancer Science 103(1):26-33. pubmed journal




2011

T Oki, J Kitaura, N Watanabe-Okochi, K Nishimura, A Maehara, T Uchida, Y Komeno, F Nakahara, Y Harada, T Sonoki, H Harada, T Kitamura Aberrant expression of RasGRP1 cooperates with gain-of-function NOTCH1 mutations in T-cell leukemogenesis. Leukemia 26, 1038-1045 pubmed


Enomoto Y, Kitaura J, Hatakeyama K, Watanuki J, Akasaka T, Kato N, Shimanuki M, Nishimura K, Takahashi M, Taniwaki M, Haferlach C, Siebert S, Dyer MJS, Asou N, Nakakuma H, Kitamura T, Sonoki T. Em/miR-125b transgenic mice develop lethal B-cell malignancies. Leukemia 25:1849-1856. pubmed


Kato N, Kitaura J, Doki N, Komeno Y, Watanabe-Okochi N, Togami K, Nakahara F, Oki T, Enomoto Y, Fukuchi Y, Nakajima H, Harada Y, Harada H, Kitamura T. Two types of C/EBP-alpha mutations play distinct roles in leukemogenesis: Lessons from clinical data and BMT models. Blood 117:221-233. pubmed




2010

Nakajima H, Ito M, Smookler DS, Shibata F, Fukuchi Y, Morikawa Y, Ikeda Y, Arai F, Suda T, Khokha R, Kitamura T. TIMP-3 recruits quiescent hematopoietic stem cells into active cell cycle and expands multipotent progenitor pool. Blood 116:4474-4482.


Enomoto Y, Yamanishi Y, Izawa K, Kaitani A, Takahashi M, Maehara A, Oki T, Kajikawa M, Takai T, Kitamura T, Kitaura, J. Characterization of leukocyte mono-Ig receptor 7 (LMIR7)/CLM3 as an activating receptor: Its similarities to and differences from LMIR4/CLM5. J. Biol. Chem. 285: 35274-35283.


Yamanishi Y, Kitaura J, Izawa K, Kaitani A, Komeno Y, Nakamura M, Yamazaki S, Enomoto Y, Oki T, Akiba H, Komori T, Morikawa Y, Kiyonari H, Takai T, Okumura K, Kitamura, T TIM1 is an endogenous ligand for LMIR5/CD300b and LMIR5 deficiency ameliorates mouse kidney ischemia/reperfusion injury. J. Exp. Med. 207:1501-1511.


Nakahara F, Sakata-Yanagimoto M, Komeno Y, Kato N, Uchida T, Haraguchi K, Kumano K, Harada Y, Harada H, Kitaura J, Ogawa S, Kurokawa M, Kitamura T, Chiba S. Hes1 immortalizes committed progenitors and plays a role in blast crisis transition in chronic myelogeneou leukemia. Blood 115: 2872-2881.


Komeno Y, Kitaura J, Watanabe-Okochi N, Kato N, Oki T, Nakahara F, Harada Y, Harada H, Shinkura R, Nagaoka H, Hayashi Y, Honjo T, Kitamura T. AID-induced T-lymphoma or B-leukemia/lymphoma in a mouse BMT model. Leukemia 24:1018-1024.




2009

Islam, S.M., Shinmyo, Y., Okafuji, T., Su, Y., Naser, I.B., Ahmed, G., Zhang, S., Chen, S., Ohta, K., Kiyonari, H., Abe, T., Tanaka, S., Nishinakamura, R., Terashima, T., Kitamura, T., and Tanaka, H. Draxin, a novel repulsive guidance protein for spinal cord and forebrain commissures. Science 323:388-393.


Komeno, Y., Kitaura, J. and Kitamura, T. Molecular bases of myelodysplastic syndromes: Lessons from animal models. J Cell. Physiol. 219:529-534.


Kawashima, T., Bao, Y.C., Minoshima, Y., Nomura, Y., Hatori, T., Hori, T., Fukagawa, T., Takahashi, N., Nosaka, T., Inoue, M., Sato, T., Kukimoto-Niino, M., Shirouzu, M., Yokoyama, S., and Kitamura, T. A Rac GTPase activating protein MgcRacGAP is an NLS-containing nuclear chaperone in the activation of STAT transcription factors. Mol Cell Biol., 29:1796-1813.


Izawa, K., Kitaura, J., Yamanishi, Y., Matsuoka, T., Kaitani, A., Sugiuchi, M., Takahashi, M., Maehara, A., Enomoto, Y., Oki, T., Takai, T. and Kitamura, T. Activating and inhibitory signals from an inhibitory receptor LMIR3/CLM-1: LMIR3 augments LPS response through association with FcRg in mast cells. J. Immunol. 183:925-936.


Doki, N., Kawashima, T., Nomura, Y., Tsuchiya, A., Oneyama, C., Akagi, T., Nojima, Y. and Kitamura, T. A Rac GTPase activating protein MgcRacGAP is constitutively phosphorylated on serine 387 in the v-Src-transformed NIH3T3 cells. Cancer Science 100:1675-1679.


Oki, T., Eto, K, Izawa, K., Yamanishi, Y., Inagaki, N., Frampton, J., *Kitamura, T., and *Kitaura, J. Evidence that integrin alpha 2b beta 3-dependent interaction of mast cells with fibrinogen exacerbates chronic inflammation. J. Biol. Chem. 284:31463-31472.


Ono, R., Kumagai, H., Nakajima, H., Hishiya, A., Taki, T., Horikawa, K., Takatsu. K., Satoh, T., Hayashi, Y., Kitamura, T., and Nosaka T. Mixed-lineage-leukemia (MLL) fusion protein collaborates with Ras to induce acute leukemia through aberrant Hox expression and Raf activation. Leukemia 23:2197-2209.




2008

Watanabe-Okochi, N., Kitaura, J., Ono, R., Harada, H., Harada, Y., Nakajima, H., Nosaka, T., Inaba, T., and Kitamura, T. AML1 mutations induced MDS and MDS/AML in a mouse BMT model. Blood 111: 4297-4308.


Yamanishi, Y., Kitaura, J., Izawa, K., Matsuoka, T., Oki, T., Lu, Y., Shibata, F., Yamazaki, S., Kumagai. H., Nakajima, H.,, Maeda-Yamamoto, M., Tybulewicz, V.L.J., Takai, T., and Kitamura, T. Analysis of mouse LMIR5/CLM7 as an activating receptor: differential regulation of LMIR5/CLM7 between mouse and human. Blood 111:688-698.


Kawashima, T., and Kitamura, T. Rac and Nuclear Translocation of STAT Transcription Factors. Methods in Enzymology 431:171-180.


Hiwatari, M., Ono, R., Taki, T., Hishiya, A., Ishii, E., Kitamura, T., Hayashi, Y., and Nosaka, T. Novel gain-of-function mutation in the extracellular domain of the PDGFRA gene in infant acute lymphoblastic leukemia with t(4;11)(q21;q23). Leukemia 22: 2279-2280.




2007

Izawa, K., Kitaura, J., Yamanishi, Y., Matsuoka, T., Oki, T., Shibata, F., Kumagai, H., Nakajima, H., Maeda-Yamamoto, M., Hauchins, J.P., Tybulewicz, V.L.J., Takai, T., and Kitamura, T. Functional analysis of an activating receptor LMIR4 as a counterpart of an inhibitory receptor LMIR3. J. Biol. Chem. 25: 17997-18008.


Lu, Y., Kitaura, J., Oki, T., Komeno, Y., Ozaki, K., Kiyono, M., Kumagai, H., Nakajima, H., Aburatani, H. and Kitamura, T. Identification of TSC-22 as a potential tumor suppressor that is upregulated by Flt3-D835V but not Flt3-ITD. Leukemia 21:2246-2257.


Miyanishi, M., Tada, K., Koike, M., Uchiyama, Y., Kitamura, T., and Nagata, S. Identification of TIM4 as a phosphatidylserine receptor for engulfment of apoptotic cells. Nature 450:435-440.




2006

Oki, T., Kitaura, J., Eto, K., Maeda-Yamamoto, M., Inagaki, N., Nagai, H., Yamanishi, Y., Kumagai, H. and Kitamura, T. Integrin alpha-IIb-beta-3 induces the adhesion and activation of mast cells through interaction with fibrinogen. J. Immunol. 176:52-60.


Nakajima, H., Shibata, F., Fukuchi, Y., Goto-Koshino, Y., Ito, M., Urano, A., Nakahata, T., Aburatani, H., and Kitamura, T. Immune suppressor factor confers stromal cell line with enhanced supporting activity for hematopoietic stem cells. Biochem. Biophys. Res. Commun. 340: 35-42.


Fukuchi, Y., Shibata, F., Ito, M., Goto-Koshino, Y., Sotomaru, Y., Ito, M., Kitamura, T., and Nakajima, H. Comprehensive analysis of myeloid lineage conversion using mice expressing an inducible form of C/EBP-alpha. EMBO J. 25: 3398-3410.


Kawashima, T., Bao, Y.C., Nomura, Y., Moon, Y., Tonozuka, Y., Minoshima, Y., Hatori, T., Kiyono, M., Nosaka, T., Nakajima, H., Williams, D.A., and Kitamura, T. Rac1 and a GTPase activating protein MgcRacGAP are required for nuclear translocation of STAT transcription factors. J. Cell Biol. 175: 937-946.




2005

Ono, R., Nakajima, H., Ozaki, K., Kumagai, H., Kawashima, T., Taki, T., Kitamura, T., Hayashi, Y. and Nosaka, T. Dimerization of MLL fusion proteins and FLT3 activation synergize to induce multiple lineage leukemogenesis. J. Clin. Invest. 115:919-929.


Urano, A., Endoh, M., Wada, T., Morikawa, Y., Itoh, M., Kataoka, Y., Taki, T., Akazawa, H., Nakajima, H., Komuro, I., Yoshida, N., Hayashi, Y., Handa, H., Kitamura, T. and Nosaka T. Infertility with defective spermiogenesis in mice lacking AF5q31, the target of chromosomal translocation in human infant leukemia. Mol. Cell. Biol. 15: 6834-6845.


Minoshima, Y., Hori, T., Okada, M., Kimura, H., Haraguchi. T., Hiraoka, Y., Bao, Y-C., Kawashima, T., *Kitamura, T., and *Fukagawa, T. The constitutive centromere component CENP-50 is required for recovery from spindle damage. Mol. Cell. Biol. 25:10315-10328.


Ono, R., Ihara, M., Nakajima, H., Ozaki, K., Kataoka-Fujiwara, Y., Taki, T., Nagata, K., Inagaki, M., Yoshida, N., Kitamura, T., Hayashi, Y., Kinoshita, M. and Nosaka, T. Disruption of Sept6, a fusion partner gene of Mixed Lineage Leukemia (MLL), does not affect the ontogeny, leukemogenesis induced by MLL-SEPT6, or the phenotype induced by the loss of Sept4. Mol. Cell. Biol. 25: 10965-10978.




2004

Ikeda, Y., Imai, Y., Kumagai, H., Nosaka, T., Morikawa, Y., Hisaoka, T., Manabe, I., Maemura, K., Nakaoka, T., Imamura, T., Miyazono, K., Komuro, I., Nagai, R. and Kitamura, T. Vasorin, a novel TGF-beta binding protein expressed in vascular smooth muscle cells, modulates the arterial response to injury in vivo. Proc. Natl. Acad. Sci. U.S.A. 101:10732-10737.


Tonozuka, Y., Minoshima, Y., Bao, Y.C., Moon, Y., Tsubono, Y., Hatori, T., Nakajima, H., Nosaka, T., Kawashima, T. and Kitamura, T. A GTPase activating protein binds STAT3 and is required for IL-6-induced STAT3 activation and differentiation of a leukemic cell line. Blood 104: 3550-3557.




2003

Ozawa, T., Sako, Y., Sato, M., Kitamura, T., and Umezawa, Y. A genetic approach to identifying mitochondrial proteins. Nat. Biotechnol. 21:287-293.


Minoshima, Y., Kawashima, T., Hirose, K., Tonozuka, Y., Kawajiri, A., Bao, Y-C., Deng, X., Tatsuka, M., Narumiya, S., May, W.S. Jr., Nosaka, T., Senba, K., Inoue, T., Satoh, T., Inagaki, M., and Kitamura, T. Phosphorylation by Aurora B converts MgcRacGAP to a RhoGAP during cytokinesis. Dev. Cell 4:549-560.


Nosaka, T., Morita, S., Kitamura, H., Nakajima, H., Shibata, F., Morikawa, Y., Kataoka, Y., Ebihara, Y., Kawashima, T., Itoh, T., Ozaki, K., Senba, E., Tsuji, K., Makishima, F., Yoshida, N., and Kitamura, T. Mammalian twisted gastulation is essential for skeleto-lymphogenesis. Mol. Cell. Biol. 23: 2969-2980.


Kitamura, T., Koshino, Y., Shibata, F., Nakajima, H., Nosaka, T., and Kumagai, H. Retrovirus-mediated gene transfer and expression cloning, powerful tools in functional genomics. Exp. Hematol. 31: 1007-1014.


Murata, K., Kumagai, H., Kawashima, T., Irie, M., Nakajima, H., Tamitsu, K., Nosaka, T., Asano, S., and Kitamura, T. A novel tyrosine kinase inhibitor GTP14564 specifically inhibits constitutively active fms-like tyrosine kinase 3 through inactivation of STAT5. J. Biol. Chem. 278: 32892-32898.


Ueno, H., Sakita-Ishikawa, M., Morikawa, Y., Nakano, T., Kitamura, T., and Saito, M. A stromal cell-derived membrane protein that supports hematopoietic stem cells. Nat. Immunol. 4: 457-463.


Kumagai, H., Oki, T., Tamitsu, K., Feng, S-Z., Ono, M., Nakajima, H., Bao, Y-C., Kawakami, Y., Nagayoshi, K., Copeland, N.G., Gilbert, D.J., Jenkins, N.A., Kawakami, T., and Kitamura, T. Identification and characterization of a new pair of immunoglobulin-like receptors LMIR1 and 2 derived from murine bone marrow-derived mast cells. Biochem. Biophys. Res. Commun. 307: 719-729.




2002

Tulin, E. E., Onoda, N., Hasegawa, M., Nosaka, T., Nomura, H. and Kitamura, T. Genetic approach and phenotype-based complementation screening for identification of stromal cell-derived proteins involved in cell proliferation. Exp. Cell Res. 272:23-31.


Tulin, E. E., Onoda, N., Hasegawa, M., Nomura, H. and Kitamura, T. Inhibition of human endothelial cell proliferation by ShIF, a vacuolar H+-ATPAse-like protein. Oncogene 21:844-848.


Nosaka, T. and Kitamura, T. Pim-1 expression is sufficient to induce cytokine independence in murin hematopoietic cells, but is dispensable for BCR-ABL-mediated transformation. Exp. Hematol. 30:697-702.


Nagai, Y., Akashi, S., Nagafuku, M., Ogata, M., Iwakura, Y., Akira, S., Kitamura, T., Kosugi, A., Kimoto, M., and Miyake, K. Essential role of MD-2 in LPS responsiveness and TLR4 distribution. Nat. Immunol. 3:667-672.



2001

Hirose, K., Kawashima, T., Iwamoto, I., Nosaka, T., and >Kitamura, T. MgcRacGAP is involved in cytokinesis through associating with mitotic spindle and midbody. J. Biol. Chem. 276:5821-5828.


Kawashima, T., Murata, K., Akira, S., Tonozuka, Y., Minoshima, Y., Feng, S., Kumagai, H., Tsuruga, H., Ikeda, Y., Asano, S., Nosaka, T., and Kitamura, T. STAT5 induces macrophage differentiation of M1 leukemia cells through activation of IL-6 production mediated by NF- B p65. J. Immunol. 167:3652-3660.


Tonozuka, Y., Fujio, K., Sugiyama, T., Nosaka, T., Hirai, M., and Kitamura, T. Molecular cloning of a human novel type I cytokine receptor related to Delta1. Cytogenetics and Cell Genetics 93:23-25.


Tulin, E.E., Onoda, N., Maeda, M., Hasegawa, M., Nosaka, T., Nomura, H., Asano, S., and Kitamura, T. A novel secreted form of immune suppressor factor with high homology to vacuolar ATPase identified by forward genetic approach of functional screening based on cell proliferation. J. Biol. Chem. 276:27519-27526.


Ye, S.K., Agata, Y., Lee, H.C., Kurooka, H., Kitamura, T., Shimizu, A., Honjo, T. and Ikuta, K. The IL-7 receptor controls the accessbility of the TCR locus by Stat5 and histone acetylation. Immunity 15: 813-823.




2000

Yamada, K., Ariyoshi, K., Onishi, M., Miyajima, A., Hayakawa, F., Towatari, M., Saito, H., Oka, Y., Asano, S., Nosaka, T. and Kitamura, T. Constitutively active STAT5A and STAT5B in vitro and in vivo: mutation of STAT5 is not a frequent cause of leukemogenesis. Int. J. Hematol. 71, 46-54.


Fujio, K., Nosaka, T., Kojima, T., Kawashima, T., Yahata, T., Copeland, N.G., Gilbert, D.J., Jenkins, N.A., Yamamoto, K, Nishimura, T. and Kitamura, T. Molecular cloning of a novel type I cytokine receptor similar to the common gamma chain. Blood 95:2204-2211.


Misawa, K., >Nosaka, T., Kojima, T., Hirai, M. and Kitamura, T. Molecular cloning and characterization of a mouse homolog of human TNFSF14, a member of the TNF superfamily. Cytogenetics and Cell Genetics 89:89-91.


Misawa, K., Nosaka, T., Morita, S., Kaneko, A., Nakahata, T., Asano, S. and Kitamura, T. A method to identify cDNAs based on localization of green fluorescent protein fusion products. Proc. Natl. Acad. Sci. U.S.A. 97:3062-3066.


Morita, S., Kojima, T., and Kitamura, T. Plat-E: an efficient and stable system for transient packaging of retroviruses. Gene Therapy 7:1063-1066.


Tsuruga, H., Kumagai, H., Kojima, T., and Kitamura, T. Identification of novel membrane and secreted proteins upregulated during adipocyte differentiation. Biochem. Biophys. Res. Commun. 272:293-297.


Fujio, K., Misaki, Y., Setoguchi, K., Morita, S., Kawahata, K., Nosaka, T., Yamamoto, K., and Kitamura, T. Functional reconstitution of Class-II MHC-restricted T cell immunity mediated by retroviral transfer of the αβTCR complex. J. Immunol. 165: 528-533.


Kojima, T., Morikawa, Y., Copeland, N.G., Gilbert, D.J., Jenkins, N.A., Senba, E. and Kitamura, T. Troy, a newly identified member of the tumor necrosis factor receptor superfamily, exhibits a homology with Edar and is expressed in embryonic skin and hair follicles. J. Biol. Chem. 275: 20742-20747.


Ariyoshi, K., Nosaka, T., Yamada, K., Onishi, M., Miyajima, A., and Kitamura, T. Constitutive activation of STAT5 by a point mutation in the SH2 domain. J. Biol. Chem. 275: 24407-24413.


Kawashima, T., Hirose, K., Satoh, T., Kaneko, A., Ikeda, Y., Kaziro, Y., Nosaka, T. and Kitamura, T. MgcRacGAP is involved in the control of growth and differentiation of hematopoietic cells. Blood 96, 2116-2124.


Schwaller, J., Parganas, E., Wang, D., Cain, D., Aster, J.C., Williams, I.R., Lee, C-K., Gerthner, R., Kitamura, T., Frantsve, J., Anastasiadou, E., Loh, M.L., Levy, D.E., Ihle, J.N., and Gilliland, D.G. Stat5 is essential for the myelo- and lymphoproliferative disease induced by TEL/JAK. Mol. Cell 6, 693-704.


Sugiyama, T., Kumagai, H., Morikawa, Y., Wada, Y., Sugiyama, A., Yasuda, K., Yokoi, N., Kojima, T., Nosaka, T., Senba, E., Kimura, S., Kadowaki, T., Kodama, T., and Kitamura, T. A novel low-density lipoprotein receptor-related protein mediating cellular uptake of apolipoprotein E-enriched beta-VLDL in vitro. Biochemistry 39, 15817-15825.




1999

Yang, Y-L., Lei, G., Xu, S., Holland, C.A., Kitamura, T., Hunter, K. and Cunningham, J.M. Receptors for polytropic and xenotropic murine leukemia viruses encoded by a single gene at Rmc1. Nature Genetics 21, 216-219.


Kojima, T., and Kitamura, T. A signal sequence trap based on a constitutively active cytokine receptor. Nature Biotechnol. 17: 487-490.


Nosaka, T., Kawashima, T., Misawa, K., Ikuta, K., Mui, A.L.F. and Kitamura, T. STAT5 as a molecular regulator of proliferation, differentiation and apoptosis in hematopoietic cells. EMBO J. 18, 4754-4765.


Ye, S.K., Maki, K., Kitamura, T., Sunaga, S., Akashi, K., Domen, J., Weissman, I.L., Honjo, T. and Ikuta, K. Induction of germline transcription in the TCRg locus by Stat5: implications for accessibility control by the IL-7 receptor. Immunity 11:213-223.




1998

Onishi, M., Nosaka, T., and Kitamura, T. Cytokine receptors: Structures and signal transduction. Int. Rev. Immunol. 16:617-634.


Morikawa, Y., Nishida, H., Misawa, K., Nosaka, T., Miyajima, A., Senba, E. and Kitamura, T. Induction of synaptosomal-associated protein-23kd (SNAP-23) by various cytokines. Blood 92, 129-135.


Onishi, M., Nosaka, T., Misawa, K., Mui, A.L.-F., Gorman, D., McMahon, M., Miyajima, A., and Kitamura, T. Identification and characterization of a constitutive active STAT5 mutant that promotes cell proliferation. Mol. Cell. Biol. 18:3871-3879.