研究業績

 

<2016>

Foxc2creERT2 knock-in mice mark stage-specific Foxc2-expressing cells during mouse organogenesis.
:Amin,M., Miura,N.,Uddin,M.,Islam,M., Yoshida,N.,Sachiko Iseki S.,Tsutomu Kume,T.,Trainor,P.,Hirotomo, S., Aoto,K.
Congenit.Anomal.,in press

Role of transcription factor Tgif2 in photoreceptor differentiation in the mouse retina
:Kuribayashi, H., Tsuhako, A., Kikuchi, M., Yoshida, N., Koso, H. and Watanabe, S.
Exp. Eye Res., in press

Zhang, X., Chen, H., Wu. X., Kodani, A., Fan, J., Doan, R., Ozawa, M., Ma, J., Yoshida, N., Reiter. J., Black, D., Kharchenko, P., Sharp and P., Walsh, C.
: Cell type-specific alternative splicing governs cell fate in the developing cerebral cortex.
Cell, 166: 1147-1162, 2016
< http://www.cell.com/fulltext/S0092-8674(16)30932-1>

Ozawa Manabu, Sakatani Miki, Dobbs Kyle, Kannampuzha-Francis Jasmine, Hansen Peter
: Regulation of gene expression in the bovine blastocyst by colony stimulating factor 2.
BMC Research Notes, 9:250, 2016
<http://bmcresnotes.biomedcentral.com/articles/10.1186/s13104-016-2038-y
>

Ozawa M, Fukuda T, Sakamoto R, Honda H, Yoshida N
: The Histone Demethylase FBXL10 Regulates the Proliferation of Spermatogonia and Ensures Long-Term Sustainable Spermatogenesis in Mice.
Biology of Reproduction.
<http://www.biolreprod.org/content/94/4/92.full>

Ichise, H, Ichise, T, and Yoshida, N
: Phospholipase Cγ2 Is Required for Luminal Expansion of the Epididymal Duct during Postnatal Development in Mice.
PLoS ONE 11(3): e0150521, 2016
<http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0150521
>

Ichise, H, Hori, A, Shiozawa, S, Kondo, S, Kanegae, Y, Saito, I, Ichise, T, and Yoshida, N
: Establishment of a tamoxifen-inducible Cre-driver mouse strain for widespread and temporal genetic modification in adult mice.
Exp Anim. 15-0126, Advance Publication, February 29, 2016
<https://www.jstage.jst.go.jp/article/expanim/advpub/0/advpub_15-0126/_article>

<2015>

Uddin, M.K., Kimura, W., Ishikura, T., Koseki, H., Yoshida, N., Islam, M.J., Amin, M.B., Nakamura, K., Wu, Y.X., Sato, E., Aoto, K., Miura, N.
: Foxc2 in pharyngeal arch mesenchyme is important for aortic arch artery remodelling and ventricular septum formation.
Biomed. Res., 36: 235-245, 2015

Shimbo, M. et al.:Ground-based assessment of JAXA mouse habitat cage unit by mouse phenotypic studies.
Exp. Anim., in press

Tateishi, R., Akiyama, N., Miyauchi, M., Yoshinaga, R., Sasanuma, H.,
Kudo, T., Shimbo, M., Shinohara, M., Obata, K., Inoue, J., Shirakawa, M., Shiba, D., Asahara, H., Yoshida, N., Takahashi, S. Morita, H. and Akiyama, T.
: Hypergravity provokes a temporary reduction in CD4+CD8+ thymocyte number and a persistent decrease in medullary thymic epithelial cell frequency in mice.
PLoS ONE, 10(10):e0141650,2015

Varney, M.E., Niederkorn, M., Konno, H., Matsumura, T., Gohda, J., Yoshida, N., Akiyama, T., Christie, S., Fang, J., Miller, D., Jerez, A., Karsan, A., Maciejewski, J.P., Meetei, R.A., Inoue, J. and Starczynowski, D.T.
: Loss of Tifab, a del(5q) MDS gene, alters hematopoiesis through derepression of Toll-like receptor/TRAF6 signaling.
J. Exp. Med., 212(11) 1967-1985,2015

Chimura, T., Launey, T. and Yoshida, N.
:Calpain-mediated degradation of drebrin by excitotoxicity in vitro and in vivo.
PLoS One, 10(4): e0125119,2015 <http://www.ncbi.nlm.nih.gov/pubmed/25905636>

<2014 >

Kawakami, E., Tokunaga, A., Ozawa, M., Sakamoto, R. and Yoshida, N.
: The histone demethylase Fbxl11 plays an essential role in embryonic development by repressing cell-cycle regulators.
Mech. Develop., 135:31-42, 2014 <http://www.ncbi.nlm.nih.gov/pubmed/25463925>

Arimura, S., Okada, T., Tezuka, T., Chiyo, T., Kasahara, Y., Yoshimura, T., Motomura, M., Yoshida, N., Beeson, D., Takeda, S. and Yamanashi, Y.
: DOK7 Gene Therapy Benefits Mouse Models of Diseases Characterized by Defects in the Neuromuscular Junction.
Science,345: 1505-1508, 2014

Okura, H., Sato, S., Kishikawa, S., Kaneto, S., Nakashima, T., Yoshida, N., Takayanagi, H. and Kiyono, H.
: Runx2-I Isoform Contributes to Fetal Bone Formation Even in the Absence of Specific N-Terminnal Amino Acids.
PLoS ONE, 9: e108294, 2014

Ozawa,M., Kawakami,E., Sakamoto,R., Shibasaki,T., Goto,A. and Yoshida,N.
: Development of FGF2-dependent pluripotent stem cells showing naïve state characteristics from murine preimplantation inner cell mass.
Stem Cell Research,Stem Cell Res., 13: 75-87, 2014 <http://www.ncbi.nlm.nih.gov/pubmed/24835670>

Nasu, M., Yada, S., Igarashi, A., Den'etsu Sutoo, Akiyama, K., Ito, M., Yoshida, N. and Ueda, S.
:Mammalian-Specific Sequences in Pou3f2 Contribute to Maternal Behaviour.
Genome Biol Evol., 6: 1145-1156, 2014

Ichise, H., Ichise, T., Sasanuma, H., Yoshida, N.
: The Cd6 gene as a permissive locus for targeted transgenesis in the mouse.
Genesis, 52: 440-450, 2014 <http://www.ncbi.nlm.nih.gov/pubmed/24700560>

Katayama H., Mori. T., Seki, Y., Anraku, M., Iseki, M., Ikutani, M., Iwasaki, Y., Yoshida, N., Takatsu, K. and Takaki, S.
:Lnk prevents inflammatory CD8+ T-cell proliferation and contributes to intestinal homeostasis.
Eur. J. Immunol., 44: 1622-1632, 2014

Ichise, T., Yoshida, N. and Ichise, H.
: FGF2-induced Ras/Erk MAPK signalling maintains lymphatic endothelial cell identity by up-regulating endothelial cell-specific gene expression and suppressing TGFβ signalling via Smad2.
J. Cell Sci., 127:845-57,2014 <http://www.ncbi.nlm.nih.gov/pubmed/24357720>

<2013>

Yanai, H., Matsuda, A., An, J., Koshiba, R., Nishio, J., Negishi, H., Ikushima, H., Onoe, T., Ohdan, H., Yoshida, N. and Taniguchi, T.
: Conditional ablation of HMGB1 in mice reveals its protective function against endotoxemia and bacterial infection.
Proc. Natl. Acad. Sci., USA, 110(51):20699-704, 2013

Sakaki-Yumoto, M., Liu, J., Ramalho-Santos, M., Yoshida N. and Derynck, R.
: Smad2 is essential for maintenance of the human and mouse primed pluripotent stem cell state.
J. Biol. Chem., 288:18546-18560, 2013

Shibasaki, T., Tokunaga, A., Sakamoto, R., Sagara, H., Noguchi, S, Sasaoka, T. and Yoshida, N.
:PTB deficiency causes the loss of adherens junctions in the dorsal telencephalon and leads to lethal hydrocephalus.
Cereb. Cortex, 23:1824-1835,2013 <http://www.ncbi.nlm.nih.gov/pubmed/22705452 >

<2012>

Ichise, T., Yoshida, N., and Ichise, H.
:Ras/MAPK Signaling Modulates VEGFR-3 Expression through Ets-mediated p300 Recruitment and Histone Acetylation on the Vegfr3 Gene in Lymphatic Endothelial Cells. PLoS ONE, 7:e51639,2012 <http://www.ncbi.nlm.nih.gov/pubmed/23284731>

<2011>

Oyama, T., Harigaya, K., Sasaki, N., Okamura, Y., Saga, Y., Hozumi, K., Suganami, A., Tamura, Y., Nagase, T., Koga, H., Nishimura, M.,
Sakamoto, R., Sato, M., Yoshida, N., Kitagawa, M.
:Mastermind-like 1 (MamL1)/Mastermind-like 3 (MamL3) are essential for Notch signaling in vivo.
Development,138: 5235-5246,2011.

Ohno, S., Shibayama, M., Sato, M., Tokunaga, A. and Yoshida, N.
: Polypyrimidine tract-binding protein regulates the cell cycle through IRES-dependent translation of CDK11p58 in mouse embryonic stem cells.
Cell Cycle,10: 3706-3713, 2011.

Morita, M., Oike, Y., Nagashima, T,, Kadomatsu, T., Tabata, M., uzuki, T., Nakamura, T., Yoshida, N., Okada, M. and Yamamoto, T.
: Obesity resistance and increased hepatic expression of catabolism-related mRNAs in Cnot3+/- mice.
EMBO J., 30, 4678-4691,2011.

Fukui, R.,, Saitoh, S-I., Kanno, A., Onji, M., Takuma Shibata, T., Itoh, A., Yoshid, N. & Kensuke Miyake.
:Unc93B1 restricts systemic lethal inflammation by orchestrating TLR7- and TLR9-trafficking.
Immunity, 35: 69, 2011

Fukuda, T., Tokunaga, A., Sakamoto, R. and Yoshida, N.
: Fbxl10/Kdm2b deficiency accelerates neural progenitor cell death and leads to exencephaly.
Mol. Cell. Neurosci., 46: 614, 2011

<2010>

Funato, Y., Terabayashi, T., Sakamoto, R., Okuzaki, D., Ichise, H., Hiroshi Nojima, H., Yoshida, N. and Miki, H.
: Nucleoredoxin sustains Wnt/β-catenin signaling by retaining a pool of inactive Dishevelled protein.
Curr. Biol., 20: 1945, 2010

Hayashi, T., Funato, Y., Tearabayashi, T., Morinaka, A., Sakamoto, R., Ichise, H.,Fukuda, H., Yoshida, N. and Miki, H.
: Nucleoredoxin negatively regulates toll-like receptor 4 signaling via recruitment of flightless-I to myeloid differentiation primary response gene (88).
J. Biol. Chem., 285: 18586, 2010

Ichise, T., Yoshida, N. and Ichise, H.
:H-, N- a
nd Kras cooperatively regulate lymphatic vessel growth by modulating VEGFR3
expression in lymphatic endothelial cells in mice.
Development, 137: 1003-1013, 2010

Murohashi, M., Nakamura, T., Tanaka, S., Ichise, T., Yoshida, N.,Yamamoto, T., Shibuya, M., Schlessinger, J., Gotoh, N.
: An FGF4-FRS2αlpha-Cdx2 axis in trophoblast stem cells induces BMP4 to regulate proper growth of early mouseembryos.
Stem Cells, 28:113-121.2010

<2009>

Shibayama, M., Ohno, S., Osaka, T., Sakamoto, R., Tokunaga, A.,Nakatake, Y., Sato, M. and Yoshida, N.
: Polypyrimidine tract-binding protein is essential for early mouse development and embryonic stem cell proliferation.
FEBS J., 276(22):6658-68.2009

Chizu Tanikawa, Koji Ueda, Hidewaki Nakagawa, Nobuaki Yoshida, Yusuke Nakamura and Koichi Matsuda.
: Regulation of protein Citrullination through p53/PADI4 network in DNA damage response.
Cancer Res,69(22):8761-9.2009

Tanikawa,C.,Furukawa,Y.,Yoshida,N.,Arakawa,H.,Nakamura,Y.,and Matsuda,K.
: XEDAR as a putative colorectal tumor suppressor that mediates p53-regulated anoikis pathway.
Oncogene, 28(34):3081-92.2009

Ichise, H., Ichise, T., Ohtani, O. and Yoshida, N.
: Phospholipase Cγ2 is necessary for separation of blood and lymphatic vasculature in mice.
Development, 136: 191-195.2009

Murata J, Ohtsuka T, Tokunaga A, Nishiike S, Inohara H, Okano H, Kageyama R.
:Notch-Hes1 pathway contributes to the cochlear prosensory formation potentially through the transcriptional down-regulation of p27Kip1.
J Neurosci Res. 87(16):3521-34.2009

<2008>

Yamaguchi, T., Ichise, T., Iwata, O., Hori, A., Adachi, T., Yoshida, N. and Ichise, H.
: Development of a new method for isolation and long-term culture of organ-specific blood vascular and lymphatic endothelial cells of the mouse.
FEBS J., 275: 1988-1998, 2008

<2007>

Rikimaru, A., Komori, K., Sakamoto, T., Ichise, H., Yoshida, N., Yana, I. and Seiki, M.
: Establishment of an MT4-MMP-deficient mouse strain representing an efficient tracking system for MT4-MMP/MMP-17 expression in vivo using β-galactosidase.
Genes Cells, 12: 1091-1100, 2007


Oyama, T., Harigaya, K., Muradil, A., Hozumi, K., Habu, S., Oguro, H., Iwama, A., Matsuno, K., Sakamoto, R., Sato, M., Yoshida, N. and Kitagawa, M.
: Mastermind-1 is required for Notch signal-dependent steps in lymphocyte development in vivo.
Proc. Natl. Acad. Sci., USA 104: 9764-9769, 2007

Suetsugu, S., Banzai, Y., Kato, M., Fukami, K., Kataoka, Y., Takai, Y., Yoshida, N., Takenawa, T.
: Male-specific sterility caused by the loss of CR16.
Genes Cells, 12: 721-33, 2007


Anan, K., Yoshida, N., Kataoka, Y., Sato, M., Ichise, H., Nasu, M., Ueda, S.
: Morphological Change Caused by Loss of the Taxon-Specific Polyalanine Tract in Hoxd-13.
Mol. Biol. Evol., 24: 281-287, 2007

<2006>


Kawa, S., Ito, C., Toyama, Y., Maekawa, M., Tezuka, T., Nakamura, T., Nakazawa, T., Yokoyama, K., Yoshida, N., Toshimori, K. and Yamamoto, T.
: Azoospermia in mice with targeted disruption of the Brek/Lmtk2 (brain-enriched kinase/lemur tyrosine kinase 2) gene.
Proc. Natl. Acad. Sci., USA, 103: 19344-19349, 2006


Kondo, S., Takahashi, Y., Shiozawa, S.,Ichise, H., Yoshida, N., Kanegae, Y. and Saito, I.
: Efficient sequential gene regulation via FLP- and Cre-recombinase using adenovirus vector in mammalian cells including mouse ES cells.
Microbiol. Immunol., 50: 831-843, 2006


Sakaki-Yumoto, M., Kobayashi, C., Sato, A., Fujimura, S., Matsumoto, Y., Takasato, M., Kodama, T., Aburatani, H., Asashima, M., Yoshida, N. and Nishinakamura, R.
: The murine homolog of SALL4, a causative gene in Okihiro syndrome, is essential for embryonic stem cell proliferation, and cooperates with Sall1 in anorectal, heart, brain, and kidney development.
Development, 133: 3005-3013, 2006


Takayanagi, S., Hiroyama, T., Yamazaki, S., Nakajima, T., Morita, Y., Usui, J., Eto, K., Motohashi, T., Shiomi, K., Keino-Masu, K., Masu, M., Oike, Y., Mori, S., Yoshida, N., Iwama, A., Nakauchi, H.
: Genetic marking of hematopoietic stem and endothelial cells: Identification of the Tmtsp gene encoding a novel cell-surface protein with the thrombospondin-1 domain.
Blood, 107: 4317-4325, 2006

<2005>


Ono, R., Ihara. M., Nakajima, H., Ozaki, K., Kataoka-Fujiwara, Y., Taki, T., Nagata, K., Inagaki, M., Yoshida, N., Kitamura, T., Hayashi, Y., Kinoshita, M. and Nosaka, T.
; Disruption of Sept6, a fusion partner gene of Mixed Lineage Leukemia (MLL), does not affect the ontogeny, leukemogenesis induced by MLL-SEPT6, or the phenotype induced by the loss of Sept4.
Mol. Cell. Biol., 25: 10965-10978, 2005


Nakamura, Y., Hamada, Y., Fujiwara, T., Enomoto, H., Hiroe, T., Tanaka, S., Nose, M., Nakahara, M., Yoshida, N., Takenawa, T. and Fukami, K.
: Phospholipase Cδ1 and δ3 Are Essential in Trophoblast for Placental Development.
Mol. Cell. Biol., 25: 10979-10988, 2005


Urano, A., Endoh, M., Wada, T., Morikawa, Y., Itoh, M., Kataoka, Y., Taki, T., Akazawa, H., Nakajima, H., Komuro, I., Yoshida, N., Hayashi, Y., Handa, H., Kitamura,T. and Nosaka, T.
: Infertility with defective spermiogenesis in mice lacking AF5q31, the target of chromosomal translocation in human infant leukemia.
Mol. Cell. Biol., 25: 6834-6845, 2005


Honda, K., Yanai, H., Negishi, H., Asagiri, M., Sato, M., Mizutani, T., Shimada, N., Ohba, Y., Takaoka, A., Yoshida, N. and Taniguchi, T.
: IRF-7 is the master regulator of type-I interferon dependent immune responses.
Nature, 434: 772- 777, 2005


Iizasa, H., Yoneyama, H., Mukaida, N., Kataoka, Y., Naito, M., Yoshida, N.,Nakashima, E. and Matsushima, K.
: Exacerbation of Granuloma Formation in IL-1 Receptor Antagonist-Deficient Mice with Impaired Dendritic Cell Maturation Associated with Th2 Cytokine Production.
J. Immunol., 174: 3273-3280, 2005


Sakurai, Y., Ohgimoto, K., Kataoka, Y., Yoshida, N. and Shibuya, M.
: Essential role of Flk-1 (VEGF receptor 2) tyrosine residue 1173 in vasculogenesis in mice.
Proc. Natl. Acad. Sci., USA, 102: 1076-1081, 2005

<2004>


Takasato, M., Osafune, K., Matsumoto, Y., Yoshida, N., Meguro H., Aburatani, H., Asashijma, M., and Nishinakamura, R.
: Identification of kidney mesenchymal genes by a combination of microarray analysis and Sall1- GFP knockin mice.
Mech. Dev, 121: 547-557. 2004.


Iseki, M., Kubo, C., Kwon, S., Yamaguchi, A., Kataoka, Y., Yoshida, N., Takatsu, K. and Takaki, S.
: Increased numbers of B-1 cells and enhanced responses against TI-2 antigen in mice lacking APS, an adaptor molecule containing PH and SH2 domains.
Mol. Cell. Biol., 24: 2243-2250, 2004


Komori, K., Nonaka, T., Okada, A., Kinoh, H., Hayashita-Kinoh, H., Yoshida, N., Yana, I., Seiki, M.
: Absence of mechanical allodynia and -fiber sprouting after sciatic nerve injury in mice lacking membrane-type 5 matrix metalloproteinase. 
FEBS Lett., 557:125-128, 2004

<2003>


Takenaka, K., Fukami, K., Otsuki, M., Kataoka,Y., Nishikawa, S-I., Yoshida, N. and Takenawa, T.
: Role of Phospholipase C-L2, a negative regulator of calcium signaling, is required for B cell development and immune response.
Mol. Cell. Biol., 23: 7329-7338, 2003


Yamazaki, D., Suetsugu, S., Miki, H., Kataoka, Y., Nishikawa, S.-I., Fujiwara, T., Yoshida, N. and Takenawa, T.
: WAVE2 is required for directed cell migration and cardiovascular development.
Nature, 424: 452 – 456, 2003


Wang, T., Tamakoshi, T., Uezato, T., Shu, F., Kanzaki-Kato, N., Fu, Y., Koseki, H., Yoshida, N., Sugiyama, T. and Miura, N.
: Forkhead transcription factor Foxf2 (LUN)-deicient mice exhibit abnormal development of secondary palate.
Dev. Biol., 259: 83-94, 2003


Kabashima, K., Murata, T., Tanaka, H., Matsuoka, T., Sakata, D., Yoshida, N., Katagiri, K., Kinashi, T., Tanaka, T., Miyasaka, M., Nagai, H., Ushikubi, F. and Narumiya, S.
: Thromboxane A2 modulates interaction of dendritic cells and T cells and regulates acquired immunity.
Nature Immunol., 4: 694-701, 2003


Nakamura, Y., Fukami, K., Yu, H., Takenaka, K., Kataoka, Y., Shirakata. Y., Nishikawa, S-I.,Hashimoto, K., Yoshida, N. and Takenawa, T.
: Phospholipase Cδ1 is required for skin stem cell lineage commitment.
EMBO J., 22: 2981-2991, 2003


Fukami, K.,Yoshida, M.,Inoue, T.,Kurokawa, M., Fissore, R. A. ,Yoshida, N., Mikoshiba, K. and Takenawa, T.
: Phospholipase Cδ4 is required for Ca2+ -mobilization essential for acrosome reaction in sperm
J. Cell Biol., 161: 79-88, 2003


Nosaka, T., Morita, S., Kitamura, H., Nakajima, H., Shibata, F., Morikawa, Y., Kataoka, Y., Ebihara, Y., Kawashima, T., Itoh, T., Ozaki, K., Senba, E., Tsuji, K., Makishima, F., Yoshida, N. and Kitamura, T.
: Mammalian Twisted gastrulation is essential for skeleto-lymphogenesis.
Mol. Cell. Biol., 23: 2969-2980, 2003


Sato, A., Matsumoto, Y., Koide, U., Kataoka, Y., Yoshida, N., Yokota, T., Asashima, M. and Nishinakamura, R.
: Zinc finger protein sall2 is not essential for embryonic and kidney development.
Mol. Cell. Biol., 23: 62-9, 2003

<2002>


Fukuda, T., Yoshida, N., Kataoka, Y., Manabe, R., Mizuno-Horikawa, Y., Sato, M., Kuriyama, K., Yasui, N. and Sekiguchi, K.
: Mice lacking the EDB segment of fibronectin develop normally but exhibit reduced cell growth and fibronectin matrix assembly in vitro.
Cancer Res.,62: 5603-10, 2002


Honke, K., Hirahara, Y., Dupree, J., Suzuki, K., Popko, B., Fukushima, K., Fukushima, J., Nagasawa, T., Yoshida, N., Wada, Y., Taniguchi, N.
: Paranodal junction formation and spermatogenesis require sulfoglycolipids.
Proc. Natl. Acad. Sci., USA, 99: 4227-4232, 2002


Ohtsuka, S., Takaki, S., Iseki, M., Miyoshi, K., Nakagata, N., Kataoka, Y., Yoshida, N., Takatsu, K. and Yoshimura, A.
: SH2-B is Required for both Male and Female Reproduction.
Mol. Cell. Biol., 22: 3066-3077, 2002


Fukuyama, H., Adachi, M., Suematsu, S., Miwa, K., Suda, T., Yoshida, N. and Nagata, S. : Requirement of Fas expression in B cells for tolerance induction.
Eur. J. Immunol., 32: 223-230, 2002


Fukami, K., Nakao, K., Inoue, T., Kataoka, Y., Nakamura, K., Katsuki, M., Yoshida, N. and Takenawa, T.
: Requirement of phosholipase Cδ4 for the first step of fertilization.
Science, 292: 920-923, 2001


Hirata, A., Yoshida, S., Inoue, N., Matsumoto, K.,Ninomiya, A., Taniguchi, M., Matsuyama, T., Kato, K., Iizasa, H., Kataoka, Y., Yoshida, N. and Shiosaka, S.
: Abnormalities of Synapses and Neurons in the Hippocampus of Neuropsin-Deficient Mice.
Mol. Cell. Neurosci., 17: 600-610, 2001


Aono, A., Enomoto, H., Yoshida, N., Yoshizaki, K., Kishimoto, T. and Komori, T.
: Forced expression of terminal deoxynucleotidyl transferase in fetal thymus resulted in a decrease in γδT cells and random dissemination of Vγ3Vδ1 T cells in skin of newborn but not adult mice.
Immunology, 99: 489-497, 2000


Matsuoka, T., Hirata, M., Tanaka, H., Takahashi, Y., Murata, T., Kabashima, K., Sugimoto, Y., Kobayashi, T., Ushikubi, F., Aze, Y., Eguchi, N., Urade, Y., Yoshida, N., Kimura, K., Mizoguchi, A., Honda, Y., Nagai, H. and Narumiya, S.
: Prostaglandin D2 as a mediator of allergic asthma.
Science, 287: 2013 - 2017, 2000


Kaisho, T., Tsutsui, H., Tanaka, T., Tsujimura, T., Takeda, K., Kawai, T., Yoshida, N., Nakanishi, K. and Akira, S.
: Impairment of natural killer cytotoxic activity and interferon-γ production in C/EBPγ-deficient mice.
J. Exp. Med., 190: 1573-1582, 1999


Hizaki, H., Segi, E., Sugimoto, Y., Hirosa, M., Saji, T., Ushikubi, F., Matsuoka, T., Noda, Y., Tanaka, T., Yoshida, N., Narumiya, S. and Ichikawa, A.
: Abortive expansion of the cumulus and impaired fertility in mice lacking the prostaglandin E receptor subtype EP2.
Proc. Natl. Acad. Sci., USA, 96: 10501-10506, 1999


Eguchi, N., Minami, T., Shirafuji, N., Kanaoka, Y., Tanaka, T., Nagata, A., Yoshida, N., Urade, Y., Ito, S. and Hayaishi, O.
: Lack of tactile pain (allodynia) in lipocalin-type prostaglandin D synthase -deficient mice.
Proc. Natl. Acad. Sci., USA, 96: 726-730, 1999


Tanaka, T., Tsujimura, T., Takeda, K., Sugihara, A., Maekawa, A., Terada, N., Yoshida, N. and Akira, S.
: Targeted disruption of ATF4 discloses its essential role in the formation of eye lens fibres.
Genes to Cells, 3: 801-810, 1998


Takeda, K., Kaisho, T., Yoshida, N., Takeda, J., Kishimoto, T. and Akira, S.
: Stat3 activation is responsible for IL-6-dependent T cell proliferation through preventing apoptosis: Generation and characterization of T cell-specific Stat3-deficient mice.
J. Immunol., 161: 4652-4660, 1998


Ushikubi, F., Segi, E., Sugimoto, Y., Murata, T., Matsuoka, T., Kobayashi, T., Hizaki, H., Tuboi, K., Katsuyama, M., Ichikawa, A., Tanaka, T., Yoshida, N. and Narumiya, S.
: Impaired febrile response in mice lacking the prostaglandin E receptor subtype EP3.
Nature, 395: 281-284, 1998


Tachibana, K., Hirota, S., Iizasa, H., Yoshida, H., Kawabata, K., Kataoka, Y., Kitamura, Y., Matsushima, K., Yoshida, N., Nishikawa, S.-I., Kishimoto, T. and Nagasawa, T.
: The chemokine receptor CXCR4 is essential for vascularization of the gastrointestinal tract.
Nature, 393: 591-595, 1998


Segi, E., Sugimoto, Y., Yamasaki, A., Aze, Y., Oida, H., Nishimura, T., Murata, T., Matsuoka, T., Ushikubi, F., HIrose, M., Tanaka, T., Yoshida, N., Narumiya, S. and Ichikawa, A.
: Patent ductus arteriosus and neonatal death in prostaglandin receptor EP4-deficient mice.
Biochem. Biophys. Res. Commun., 246: 7-12, 1998


Fukuyama, H., Adachi, M., Suematsu, S., Miwa, K., Suda, T., Yoshida, N. and Nagata, S.
: Transgenic expression of Fas in T cells blocks lymphoproliferation but not autoimmune disease in MRL-lpr mice.
J. Immunol., 160: 3805-3811, 1998


Takeda, K., Tsutsui, H., Yoshimoto, T., Adachi, O., Yoshida, N., Kishimoto, T., Okamura, H., Nakanishi, K. and Akira, S.
: Defective NK cell activity and Th1 response in IL-18-deficient mice.
Immunity, 8: 383-390, 1998


Yoshida, K., Taga, T., Saito, M., Kumanogoh, A., Tanaka, T., Ozono, K., Nakayama, M., Nakahata, T., Yoshida, N. and Kishimoto, T.
: Myocardial, hematological, and placental disorders caused by targeted disruption of gp130, a common signal transducer for IL-6 family of cytokines.
Contemporary Immunology (ed. by Durum, S. K. et al., Humana press, NJ, USA), 259-285, 1998


Tanaka, T., Yoshida, N., Kishimoto, T. and Akira, S.
: Defective adipocyte differentiation in mice lacking the C/EBPβ and/or C/EBPδ gene.
EMBO J., 16: 7432-7443, 1997


Murakami, T., Nakajima, T., Koyanagi, Y., Tachibana, K., Fujii, N., Tamamura, H., Yoshida, N., Waki, M., Matsumoto, A., Yoshie, O.,Kishimoto, T., Yamamoto, N. and Nagasawa, T.
: A small molecule CXCR4 inhibitor that blocks T cell line tropic HIV-1 infection.
J. Exp. Med.,186: 1389-1393, 1997


Iida, K., Koseki, H., Kakinuma, H., Kato, N., Mizutani-Koseki, Y., Ohuchi, H., Yoshioka, H., Noji, S., Kawamura, K., Kataoka, Y., Ueno, F., Taniguchi, M., Yoshida, N., Sugiyama, T. and Miura N.
: Essential roles of the winged helix transcription factor MFH-1 in aortic arch patterning and skeletogenesis.
Development, 124: 4627-4638, 1997


Murata, T., Ushikubi, F., Matsuoka, T., Hirata, M., Yamasaki, A., Sugimoto, Y., Ichikawa, A., Aze, Y., Tanaka, T., Yoshida, N., Ueno, A., Oh-ishi, S. and Narymiya, S.
: Altered pain perception and inflammatory response in mice lacking prostacyclin receptor.
Nature, 388: 678-682, 1997


Sugimoto, Y., Yamasaki, A., Segi, E., Tsuboi, K., Aze, Y., Nishimura, T., Oida, H., Yoshida, N., Tanaka, T., Katsuyama, M., Hasumoto, K.-y., Murata, T., Hirata, M., Ushikubi, F., Negishi, M., Ichikawa, A., Narumiya, S.
: Failure of parturition in mice lacking the prostaglandin F receptor.
Science, 277: 681-683, 1997


Tachibana, K., Nakajima, T., Sato, A., Igarashi, K., Shida, H., Iizasa, H., Yoshida, N., Yoshie, O., Kishimoto, T. and Nagasawa, T.
: CXCR4/fusin is not a species-specific barrier in murine cells for HIV-1 entry.
J. Exp. Med.,185:1865-1870, 1997


Takeda, K., Noguchi, K., Shi, W., Tanaka, T., Matsumoto, M., Yoshida, N., Kishimoto, T. and Akira, S.
: Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality.
Proc. Natl. Acad. Sci., USA, 94: 3801-3804, 1997


Nagasawa, T., Nakajima, T., Tachibana, K., Iizasa, H., Bleul, C. C., Yoshie, O., Matsushima, K., Yoshida, N., Springer, T. A. and Kishimoto, T.
: Molecular cloning and characterization of murine pre-B cell growth stimulating factor / stromal cell-derived factor (PBSF/SDF-1) receptor, a murine homolog of HIV-1 entry coreceptor fusin.
Proc. Natl. Acad. Sci., USA, 93:14726-14729, 1996


Nagasawa, T., Hirota, S., Tachibana, K., Takakura, N., Nishikawa, S.-I., Kitamura, Y., Yoshida, N., Kikutani, H. and Kishimoto, T.
: Defects of B lymphopoiesis and bone marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1.
Nature, 382: 635-638, 1996


Texidó, G., Jacobs, H., Meiering, M., Kühn, R., Röse, J., Müller, W., Gilfillan, S., Fujiwara, H., Kikutani, H., Yoshida, N., Amakawa, R., Benoist, C., Mathis, D., Kishimoto, T., Mak, T. W. and Rajewsky, K.
: Somatic hypermutation occurs in B cells of terminal deoxynucleotidyl transferase-, CD23-, Interleukin-4-, IgD- and CD30- deficient mouse mutants.
Eur. J. Immunol., 26:1966-1969, 1996


Takeda, K., Tanaka, T., Shi, W., Matsumoto, M., Minami, M., Kashiwamura, S.-I., Nakanishi, K., Yoshida, N., Kishimoto, T., Akira,S.
: Essential role of Stat6 in IL-4 signaling.
Nature, 380:627-630, 1996


Adachi, M., Suematsu, S., Suda, T., Watanabe, D., Fukuyama, H., Ogasawara, J., Tanaka, T., Yoshida, N. and Nagata, S.
: Enhanced and accelerated lymphoproliferation in Fas-null mice.
Proc. Natl. Acad. Sci., USA, 93:2131-2136, 1996


Yoshida, K., Taga, T., Saito, M., Suematsu, S., Kumanogoh, A., Tanaka, T., Fujiwara, H., Hirata, M., Yamagami, T., Nakahata, T., Hirabayashi, T., Yoneda, Y., Tanaka, K., Wang, W.-Z., Mori, C., Shiota, K., Yoshida, N. and Kishimoto, T.
: Targeted disruption of gp130, a common signal transducer for IL-6 family of cytokines, leads to myocardial and hematological disorders.
Proc. Natl. Acad. Sci., USA, 93:407-411, 1996


Adachi, M., Suematsu, S., Kondo, T., Ogasawara, J., Tanaka, T., Yoshida, N. and Nagata, S.
: Targeted mutation in the Fas gene causes hyperplasia in the peripheral lymphoid organs and liver.
Nature Genet. 11: 294-299, 1995


Akira, S., Nishio, Y., Tanaka, T., Inoue, M., Matsusaka, T., Wang, X.-J., Wei, S., Yoshida, N. and Kishimoto, T.
: Transcription factors NF-IL6 and APRF involved in gp130-mediated signaling pathway.
Ann NY Acad. Sci. 762: 15-27, 1995


Tanaka, T., Akira, S., Yoshida, K., Umemoto, M., Yoneda, Y., Shirafuji, N., Fujiwara, H., Suematsu, S., Yoshida, N. and Kishimoto, T.
: Targeted disruption of the NF-IL6 gene discloses its essential role in bacteria killing and tumor cytotoxicity by macrophages.
Cell 80: 353-361, 1995


Fujiwara, H., Kikutani, H., Suematsu, S., Naka, T., Yoshida, K., Suemura, M.,Kishimoto,T., and Yoshida, N.
: Functional characterization of CD23 by targeted disruption of the mouse CD23 gene.
Leukocyte typing V 1: 534-535, 1995


Kawabe, T., Naka, T., Yoshida, K., Tanaka, T., Fujiwara, H., Suematsu, S., Yoshida, N., Kishimoto, T. and Kikutani, H.
: Immunoglobulin class swithcing and germinal center formation are impaired in CD40-deficient mice.
Immunity 1: 167-178, 1994


Fujiwara, H., Kikutani, H., Suematsu,S.,Naka,T., Yoshida,K., Tanaka,T., Suemura,M., Matsumoto,N., Kojima, S., Kishimoto, T. and Yoshida, N.
: The absence of IgE antibody-mediated augmentation of immune responses in CD23-deficient mice.
Proc. Natl. Acad. Sci., USA 91: 6835-6839, 1994


Kawabe, T., Yoshida, K., Yoshida, N., Kishimoto, T. and Kikutani, H.
: Generation and analysis of CD40 deficient mice.
Tissue antigens 42: 309, 1993