研究業績

代表的論文
1. Shimada, M., Goshima, T., Matsuo, H., Johmura, Y., Haruta, M., Murata, K., Tanaka, H., Ikawa, M., Nakanishi, K., and *Nakanishi, M. Essential role of auto-activation circuitry on Aurora B-mediated H2AX-pS121 in mitosis. Nature Communications 7, 12059 (2016)

2. Johmura, Y., Sun, J., Kitagawa, K., Nakanishi, K., Kuno, T., Naiki-Ito, A., Sawada, Y., Miyamoto, T., Okabe, A., Aburatani, H., ShengFan, Li., Miyoshi, I., Takahashi, S., Kitagawa, M., and *Nakanishi, M. SCFFbxo22-KDM4A targets methylated p53 for degradation and regulates senescence. Nature Communications 7, 10574 (2016)

3. Johmura, Y., Shimada, M., Misaki, T., Naiki-Ito, A., Miyoshi, H., Motoyama, N., Ohtani, N., Hara, E., Nakamura, M., Morita, A., Takahashi, S., and *Nakanishi, M. Necessary and sufficient role for a mitosis skip in senescence induction. Mol Cell 55, 73-84 (2014)

4. Hirokawa, T., Shiotani, B., Shimada, M., Murata, K., Johmura, Y., Haruta, M., Tahara, H., Takeyama, H., and *Nakanishi, M. CBP-93872 inhibits NBS1-mediated ATR activation, abrogating maintenance of the DNA double-strand break-specific G2 checkpoint. Cancer Res. 74, 3880-3889 (2014)

5. Nishiyama, A., Yamaguchi, L., Sharif, J., Johmura, Y., Kawamura, T., Nakanishi, K., Shimamura, S., Arita, K., Kodama, T., Ishikawa, F., Koseki, H., and *Nakanishi, M. Uhrf1-dependent H3K23 ubiquitylation couples maintenance DNA methylation and replication. Nature 502, 249-253 (2013)

6. Delhase, M., Kim, SY., Lee, H., Naiki-Ito, A., Chen, Y., Ahn, ER., Murata, K., Kim, SJ., Lautsch, N., Kobayashi, KS., Shirai, T., Karin, M., and Nakanishi , M. TANK-binding kinase 1 (TBK1) controls cell survival through PAI-2/serpinB2 and transglutaminase 2. Proc. Natl. Acad. Sci. 109, E177-186 (2012)

7. Shimada, M., Haruta, M., Niida, H., Sawamoto, K., and *Nakanishi, M. PP1g is a phosphatase responsible for dephosphorylation of histone H3 at threonine 11 after DNA damage. EMBO Rep. 11, 883-889 (2010)

8. Niida, H., Murata, K., Shimada, M., Ogawa, K., Ohta, K., Suzuki, K., Fujigaki, H., Khaw, A.K., Banerjee, B., Hande, P.M., Miyamoto, T., Miyoshi, I., Shirai, T., Motoyama, N., Delhase, M., Appella, E., and *Nakanishi, M. Cooperative functions of Chk1 and Chk2 reduce tumor susceptibility in vivo. EMBO J. 29, 3558-3570 (2010)

9. Niida, H., Katsuno, Y., Sengoku, M., Shimada, M., Yukawa, M., Ikura, M., Ikura, T., Kohno, K., Shima, H., Suzuki, H., Tashiro, S., and *Nakanishi, M. Essential role of Tip60-dependent recruitment of ribonucleotide reductase at DNA damage sites in DNA repair during G1 phase. Genes & Dev. 24, 333-338 (2010)

10. Katsuno, Y., Suzuki, A., Sugimura, K., Okumura, K., Zineldeen, D.H., Shimada, M., Niida, H., Mizuno, T., Hanaoka, F., and *Nakanishi, M. Cyclin A-Cdk1 regulates the origin firing program in mammalian cells. Proc. Natl. Acad. Sci. 106, 3184-3189 (2009)

11. Shimada, M., Niida, H., Zineldeen, D.H., Tagami, H., Tanaka, M., Saito, H., and *Nakanishi, M. Chk1 is a histone H3 threonine 11 kinase that regulates DNA damage-induced transcriptional repression. Cell 132, 221-232 (2008)

12. Tonami, Y., Murakami, H., Shirahige, K., and Nakanishi, M. A checkpoint control linking meiotic S phase and recombination initiation in fission yeast. Proc. Natl. Acad. Sci. 102, 5797-5801 (2005)

13. Tojima, Y., Fujimoto, A., Delhase, M., Chen, Y., Hatakeyama, S., Nakayama, K., Kaneko, Y., Nimura, Y., Motoyama, N., Ikeda, K., Karin, M., *Nakanishi, M. NAK is an IkB kinase-activating kinase. Nature 404, 778-782 (2000)

14. Takai, H., Tominaga, K., Motoyama, N., Minamishima, Y., Nagahama, H., Tsukiyama, T., Ikeda, K., Nakayama, K., *Nakanishi, M., Nakayama, K. Aberrant Cell Cycle Checkpoint Function and Early Embryonic Death in Chk1-/- Mice. Genes & Dev. 14, 1439-1447 (2000)

15. Yamamoto, A., Hashimoto, Y., Kohri, K., Ogata, E., Kato, S., Ikeda, K., *Nakanishi, M. Cyclin E as a coactivator of the androgen receptor. J. Cell Biol. 150, 873-879 (2000)

16. Nakanishi, M., Adami, G.R., Robetorye, R.S., Noda, A., Venable, S.F., Dimitrov, D., Pereira-Smith, O.M., and Smith, J.R. Exit from G0 and entry into the cell cycle of cells expressing p21Sdi1 antisense RNA. Proc. Natl. Acad. Sci. 92, 4352-4356 (1995)

17. Nakanishi, M., Robetorye, R.S., Adami, G.R., Pereira-Smith, O.M., and Smith, J.R. Identification of the active region of the DNA synthesis inhibitory gene p21Sdi1/CIP1/WAF1. EMBO J. 14, 555-563 (1995)


年度別原著論文

2016
1. Johmura, Y., Yamashita, E., Shimada, M., Nakanishi, K., and Nakanishi, M. Defective DNA repair increases susceptibility to senescence through extension of Chk1-mediated G2 checkpoint activation. Sci Rep. in press

2. Wu, W., Togashi, Y., Johmura, Y., Miyoshi, Y., Nobuoka, S., Nakanishi, M., and Ohta, T. HP1 regulates the localization of FANCJ at sites of DNA double-strand breaks. Cancer Sci. in press.

3. Kono, K., Al-Zain, A., Schroeder, L., Nakanishi, M., and Ikui, A.E. Plasma membrane/cell wall perturbation activates a novel cell cycle checkpoint during G1 in Saccharomyces cerevisiae. Proc Natl Acad Sci. 113, 6919-6915 (2016)

4. Shimada, M., Goshima, T., Matsuo, H., Johmura, Y., Haruta, M., Murata, K., Tanaka, H., Ikawa, M., Nakanishi, K., and
*Nakanishi, M. Essential role of auto-activation circuitry on Aurora B-mediated H2AX-pS121 in mitosis. Nature Communications 7, 12059 (2016)

5. Sharif J, Endo TA, Nakayama M, Karimi MM, Shimda M, Katsuyama K, Goyal P, Brind'Amour J, Sun M-A, Sun Z, Ishikura T, Mizutani-Koseki Y, Ohara O, Shinkai Y, Nakanishi M, Xie H, Lorincz MC, and Koseki H. Protracted NP95 binding to hemimethylated DNA disrupts SETDB1-mediated proviral silencing. Cell Stem Cell in press.

6. Johmura, Y., Sun, J., Kitagawa, K., Nakanishi, K., Kuno, T., Naiki-Ito, A., Sawada, Y., Miyamoto, T., Okabe, A., Aburatani, H., ShengFan, Li., Miyoshi, I., Takahashi, S., Kitagawa, M., and *Nakanishi, M. SCFFbxo22-KDM4A targets methylated p53 for degradation and regulates senescence. Nature Communications 7, 10574 (2016)


7. Misaki T, Yamaguchi L, Sun J, Orii M, Nishiyama A, Nakanishi M. The replication foci targeting sequence (RFTS) of DNMT1 functions as a potent histone H3 binding domain regulated by autoinhibition. Biochem Biophys Res Commun. 470(3):741-7.・2016 

8. Orii M, Kono K, Wen HI, Nakanishi M. PP1-Dependent Formin Bnr1 Dephosphorylation and Delocalization from a Cell Division Site. PLoS One. 11・e0146941・2016 

9. Haruta M, Shimada M, Nishiyama A, Johmura Y, Le Tallec B, Debatisse M, Nakanishi M. Loss of maintenance DNA methylation results in abnormal DNA origin firing during DNA replication. Biochem Biophys Res Commun. 469・960-6・2016 

10. Nishiyama A, Yamaguchi L, Nakanishi M. Regulation of maintenance DNA methylation via histone ubiquitylation. J Biochem. 159・9-15・2016 

2015
1. Murata K, Sato S, Haruta M, Goshima T, Chiba Y, Takahashi S, Sharif J, Koseki H, Nakanishi M, Shimada M.Physical interaction between MPP8 and PRC1 complex and its implication for regulation of spermatogenesis.
Biochem Biophys Res Commun. 458:470-5. 2015

2. Nakanishi M. [Mechanisms of maintaining genomic and epigenomic integrities]. Seikagaku. 87・165-75・2015

2014
1. Johmura Y, Shimada M, Misaki T, Naiki-Ito A, Miyoshi H, Motoyama N, Ohtani N, Hara E, Nakamura M, Morita A, Takahashi S, Nakanishi M.
Necessary and sufficient role for a mitosis skip in senescence induction.
Mol Cell. 55:73-84. 2014

2. Asano E, Ebara T, Yamada-Namikawa C, Kitaori T, Suzumori N, Katano K, Ozaki Y, Nakanishi M, Sugiura-Ogasawara M.
Genotyping Analysis for the 46 C/T Polymorphism of Coagulation Factor XII and the Involvement of Factor XII Activity in Patients with Recurrent Pregnancy Loss.
PLoS One. 9:e114452. 2014

3. CBP-93872 inhibits NBS1-mediated ATR activation, abrogating maintenance of the DNA double-strand break-specific G2 checkpoint.
Hirokawa T, Shiotani B, Shimada M, Murata K, Johmura Y, Haruta M, Tahara H, Takeyama H, Nakanishi M. Cancer Res. 74:3880-9. 2014

4. Mutational analysis of FOXL2 p.C134W and expression of bone morphogenetic protein 2 in Japanese patients with granulosa cell tumor of ovary.
Oseto K, Suzumori N, Nishikawa R, Nishikawa H, Arakawa A, Ozaki Y, Asai H, Kawai M, Mizuno K, Takahashi S, Shirai T, Yamada-Namikawa C, Nakanishi M, Kajiyama H, Kikkawa F, Sugiura-Ogasawara M. J Obstet Gynaecol Res. 40:1197-204. 2014

5. Mammal-specific H2A variant, H2ABbd, is involved in apoptotic induction via activation of NF-κB signaling pathway. 
Goshima T, Shimada M, Sharif J, Matsuo H, Misaki T, Johmura Y, Murata K, Koseki H, Nakanishi M. J Biol Chem. 289:11656-66. 2014

2013
1. Uhrf1-dependent H3K23 ubiquitylation couples maintenance DNA methylation and replication.
Nishiyama A, Yamaguchi L, Sharif J, Johmura Y, Kawamura T, Nakanishi K, Shimamura S, Arita K, Kodama T, Ishikawa F, Koseki H, Nakanishi M.
Nature 502:249-53. 2013

2. Cloning and functional characterization of Ptpcd2 as a novel cell cycle related protein tyrosine phosphatase that regulates mitotic exit.
Zineldeen DH, Wagih AA, Nakanishi M.
Asian Pac J Cancer Prev. 14:3669-76. 2013
 
3. Increased protein stability of CDKN1C causes a gain-of-function phenotype in patients with IMAGe syndrome.
Hamajima N, Johmura Y, Suzuki S, Nakanishi M, Saitoh S.
PLoS One. 8:e75137. 2013

4. Involvement of ribonucleotide reductase-M1 in 5-fluorouracil induced DNA damage in esophageal cancer cell lines.
Aoki Y, Sakogawa K, Hihara J, Emi M, Hamai Y, Kono K, Shi L, Sun J, Kitao H, Ikura T, Niida H, Nakanishi M, Okada M, Tashiro S.
Int J Oncol. 42:1951-60. 2013

2012
1. TANK-binding kinase 1(TBK1) controls cell survival through PAI-2/serpinB2 and transglutaminase 2. Delhase M, Kim SY, Lee H, Naiki-Ito A, Chen Y, Ahn ER, Murata K, Kim SJ, Lautsch N, Kobayashi KS, Shirai T, Karin M, Nakanishi M. Proc Natl Acad Sci U S A. 109:E177-86. 2012

2. Chk1 phosphorylates the tumour suppressor Mig-6, regulating the activation of EGF signalling. Liu N, Matsumoto M, Kitagawa K, Kotake Y, Suzuki S, Shirasawa S, Nakayama KI, Nakanishi M, Niida H, Kitagawa M.
EMBO J. 31:2365-77. 2012

3. Histone H1 expression in human prostate cancer tissues and cell lines. Sato S, Takahashi S, Asamoto M, Nakanishi M, Wakita T, Ogura Y, Yatabe Y,
Shirai T. Pathol Int. 62:84-92. 2012


2011
1. Nuclear Chk1 prevents premature mitotic entry. Matsuyama M, Goto H, Kasahara K, Kawakami Y, Nakanishi M, Kiyono T, Goshima N,Inagaki M. J Cell Sci. 124(Pt 13):2113-9. 2011

2. Genetic variation of the IL-28B promoter affecting gene expression. Sugiyama M, Tanaka Y, Wakita T, Nakanishi M, Mizokami M. PLoS One. 6:e26620. 2011

3. Organ differences in the impact of p27(kip1) deficiency on carcinogenesis induced by N-methyl-N-nitrosourea. Ogawa K, Murasaki T, Sugiura S, Nakanishi M, Shirai T. J Appl Toxicol. 33:471-9. 2011

4. Easy-to-use phylogenetic analysis system for hepatitis B virus infection. Sugiyama M, Inui A, Shin-I T, Komatsu H, Mukaide M, Masaki N, Murata K, Ito K, Nakanishi M, Fujisawa T, Mizokami M. Hepatol Res. 41:936-45. 2011

5. Identification of a checkpoint modulator with synthetic lethality to p53 mutants. Harada N, Watanabe Y, Yoshimura Y, Sakumoto H, Makishima F, Tsuchiya M, Nakanishi K, Nakanishi M, Aoki Y. Anticancer Drugs. 22:986-94. 2011

6. SYCP3 mutation may not be associated with recurrent miscarriage caused by aneuploidy. Mizutani E, Suzumori N, Ozaki Y, Oseto K, Yamada-Namikawa C, Nakanishi M, Sugiura-Ogasawara M. Hum Reprod. 26:1259-66. 2011

7. Novel findings for the development of drug therapy for various liver diseases: Genetic variation in IL-28B is associated with response to the therapy for chronic hepatitis C. Sugiyama M, Tanaka Y, Nakanishi M, Mizokami M. J Pharmacol Sci. 115:263-9. 2011

2010
1. Shimada, M., Haruta, M., Niida, H., Sawamoto, K., and *Nakanishi, M. PP1g is a phosphatase responsible for dephosphorylation of histone H3 at threonine 11 after DNA damage. EMBO rep. 11, 883-889 (2010)

2. Niida, H., Shimada, M., Murakami, H., and *Nakanishi, M. Mechanisms of dNTP supply that play an essential role in maintaining genome integrity in eukaryotic cells. Cancer Sci. 101, 2505-2509 (2010)

3. Niida, H., Murata, K., Shimada, M., Ogawa, K., Ohta, K., Suzuki, K., Fujigaki, H., Khaw, A.K., Banerjee, B., Hande, P.M., Miyamoto, T., Miyoshi, I., Shirai, T., Motoyama, N., Delhase, M., Appella, E., and *Nakanishi, M. Cooperative functions of Chk1 and Chk2 reduce tumor susceptibility in vivo. EMBO J. 29, 3558-3570 (2010)

4. Murakami, H., Aiba, H., Nakanishi, M., and Murakami-Tonami, Y. Regulation of yeast forkhead transcription factors and FoxM1 by cyclin-dependent and polo-like kinases. Cell Cycle 9, 3233-3242 (2010)

5. Sakai, S., Ohoka, N., Onozaki, K., Kitagawa, M., Nakanishi, M., and Hayashi, H. Dual mode of regulation of cell division cycle 25A protein by TRB3. Biol Pharm Bull. 33, 1112-1116 (2010)

6. Niida, H., Katsuno, Y., Sengoku, M., Shimada, M., Yukawa, M., Ikura, M., Ikura, T., Kohno, K., Shima, H., Suzuki, H., Tashiro, S., and *Nakanishi, M. Essential role of Tip60-dependent recruitment of ribonucleotide reductase at DNA damage sites in DNA repair during G1 phase. Genes and Dev. 24, 333-338 (2010)

7. Ohoka, N., Sakai, S., Onozaki, K., Nakanishi, M., and Hayashi, H. Anaphase promoting complex/cyclosome-cdh1 mediates the ubiquitination and degradation of TRB3. Biochem. Biophys. Res. Commun. 392, 289-294 (2010)

8. *Nakanishi, M., Katsuno, Y., Niida, H., Murakami, H., and Shimada, M. Regulation of origin firing program in mammals through Chk1-cyclin A/Cdk1 axis. Chromosomal Res. 18, 103-113 (2010)

2009
1. *Nakanishi, M., Niida, H., Murakami, H., and Shimada, M. DNA damage responses in skin biology-Implications in tumor prevention and aging acceleration. J Dermatol Sci. 56, 76-81 (2009)

2. Shimada, M., Yamamoto, A., Murakami-Tonami, Y., Nakanishi, M., Yoshida, T., Aiba, H., and Murakami, H. Casein kinase II is required for the spindle assembly checkpoint by regulating Mad2p in fission yeast. Biochem. Biophys. Res. Commun. 388, 529-532 (2009)

3. Zineldeen, D.H., Shimada, M., Niida, H., Katsuno, Y., and *Nakanishi, M. Ptpcd-1 is a novel cell cycle related phosphatase that regulates centriole duplication and cytokinesis. Biochem. Biophys. Res. Commun. 380, 460-466 (2009)

4. Nishizuka, M., Kishimoto, K., Kato, A., Ikawa, M., Okabe, M., Sato, R., Niida, H., Nakanishi, M., Osada, S., and Imagawa, M. Disruption of the novel gene fad14 causes rapid postnatal death and attenuation of cell proliferation, adhesion, spreading and migration. Exp. Cell Res. 315, 809-819 (2009)

5. Katsuno, Y., Suzuki, A., Sugimura, K., Okumura, K., Zineldeen, D.H., Shimada, M., Niida, H., Mizuno, T., Hanaoka, F., and Nakanishi, M. Cyclin A-Cdk1 regulates the origin firing program in mammalian cells. Proc. Natl. Acad. Sci. 106, 3184-3189 (2009)


2008
1. Nagata, D., Hashimoto, Y., Nakanishi, M., Naruyama, H., Okada, S., Ando, R., Tozawa, K., and Kohri, K. Peroxisome proliferator-activated receptor-gamma and growth inhibition by its ligands in prostate cancer. Cancer Detect Prev. 32, 259-266 (2008)

2. Naruyama, H., Shimada, M., Niida, H., Zineldeen, D.H., Hashimoto, Y., Kohri, K., and Nakanishi, M. Essential role of Chk1 in S phase progression through regulation of RNR2 expression. Biochem. Biophys. Res. Commun. 374, 79-83 (2008)

3. Shimada, M. and Nakanishi, M. Checkpoints meet transcription at a novel histone milestone (H3-T11). Cell Cycle 7, 1555-1559 (2008).

4. Hikosaka, A., Ogawa, K., Sugiura, S., Asamoto, M., Takeshita, F., Sato, S.Y., Nakanishi, M., Kohri, K., and Shirai, T. Susceptibility of p27 kip1 knockout mice to urinary bladder carcinogenesis induced by N-butyl-N-(4-hydroxybutyl)nitrosamine may not simply be due to enhanced proliferation. Int. J. Cancer 122, 1222-1228 (2008)

5. Shimada, M., Niida, H., Zineldeen, D.H., Tagami, H., Tanaka, M., Saito, H., and Nakanishi, M. Chk1 is a histone H3 threonine 11 kinase that regulates DNA damage-induced transcriptional repression. Cell 132, 221-232 (2008)

6. Shimada, M., Yamada-Namikawa, C., Murakami-Tonami, Y., Yoshida, T., Nakanishi, M., Urano, T., and Murakami, H. Cdc2p controls the forkhead transcription factor Fkh2 by phosphorylation during sexual differentiation in fission yeast. EMBO J. 27, 132-142 (2008)

2007
1. Murakami-Tonami, Y., Yamada-Namikawa, C., Tochigi, A., Hasegawa, N., Kojima, H., Kunimatsu, M., Nakanishi, M., and Murakami, H., Mei4p coordinates the onset of meiosis I by regulating cdc25+ in fission yeast. Proc. Natl. Acad. Sci. 104, 14688-14693 (2007)

2. Niida, H., Katsuno, Y., Prakash, H.M., and Nakanishi, M. Specific role of Chk1 phosphorylation in cell survival and checkpoint activation. Mol Cell Biol. 27, 2572-2581 (2007)

3. Iguchi, T., Miyakawa Y, Saito, K., Nakabayashi, C., Nakanishi, M., Saya, H., Ikeda, Y., and Kizaki, M. Zoledronate-induced S phase arrest and apoptosis accompanied by DNA damage and activation of the ATM/Chk1/cdc25 pathway in human osteosarcoma cells. Int. J. Oncol. 31, 285-291 (2007)

4. Nakazato, T., Nakanishi, M., Kita, S., Okuyama, F, Shibamoto, Y., and Otsuka, T. J. Radiat. Res. 48, 153-161 (2007)


2006以前
1. Shimada, M. and Nakanishi, M. DNA damage checkpoints and cancer. J. Mol Histol. 37, 253-260 (2006)

2. Nakanishi, M., Shimada, M., and Niida, H. Genetic instability in cancer cells by impaired cell cycle checkpoints. Cancer Sci. 97, 984-989 (2006)

3. Shiromizu, T., Goto, H., Tomono, Y., Bartek, J., Totsukawa, G., Inoko, A., Nakanishi, M., Matsumura, F., and Inagaki, M. Regulation of mitotic function of Chk1 through phosphorylation at novel sites by cyclin-dependent kinase 1 (Cdk1). Genes Cells. 11, 477-485 (2006)

4. Niida, H. and Nakanishi, M. DNA damage checkpoint in mammals. Mutagenesis. 21, 3-9 (2006)

5. Shimada, M., Namikawa-Yamada, C., Nakanishi, M., and Murakami, H. Regulation of Cdc2p and Cdc13p is required for cell cycle arrest induced by defective RNA splicing in fission yeast. J. Biol. Chem. 280, 32640-32648 (2005)

6. Niida, H., Tsuge, S., Katsuno, Y., Konishi, A., Takeda, N., and Nakanishi, M. Depletion of Chk1 leads to premature activation of cdc2-cyclin B and mitotic catastrophy. J. Biol. Chem. 280, 39246-39252 (2005)

7. Tonami, Y., Murakami, H., Shirahige, K., and Nakanishi, M. A checkpoint control linking meiotic S phase and recombination initiation in fission yeast. Proc. Natl. Acad. Sci. 102, 5797-5801 (2005)

8. Saitoh, T., Yamamoto, M., Miyagi, M., Taira, K., Nakanishi, M., Fujita, T., Akira, S., Yamamoto, N., and Yamaoka, S. A20 is a negative regulator of interferon regulatory factor 3 signaling. J. Immunol. 174, 1507-1512 (2005)

9. Sasai, M., Oshiumi, H., Matsumoto, M., Inoue, N., Fujita, F., Nakanishi, M., and Seya T. NF-kappaB-activating kinase (NAK)-associated protein (NAP) 1 participates in Toll-like receptor (TLR)3/Toll-IL-1 homology domain-containing adapter molecule (TICAM)-1-mediated IRF3 activation. J. Immunol. 174, 27-30 (2005)

10. Sugimoto, I., Murakami, H., Tonami, Y., Moriyama, A., and Nakanishi, M.  DNA replication checkpoint control mediated by the spindle checkpoint protein Mad2p in fission yeast. J. Biol. Chem. 279, 47372-47378 (2004)

11. Buscemi, G., Perego, P., Carenini, N., Nakanishi, M., Chessa, L., Chen, J., Khanna, K.K., and Delia, D. Activation of ATM and Chk2 kinases in relation to the amount of DNA strand breaks. Oncogene. 23, 7691-7700 (2004)

12. Lu, R., Niida, H., and Nakanishi, M. Human SAD1 kinase is involved in UV-induced DNA damage checkpoint function. J. Biol. Chem. 279, 31164-31170 (2004)

13. Matsui, T., Katsuno, Y., Inoue, Y., Fujita, F., Joh, T., Niida, H., Murakami, H., Itoh, M., and Nakanishi, M. Negative regulation of Chk2 expression by p53 is dependent on the CCAAT-binding transcription factor NF-Y. J. Biol. Chem. 279, 25093-25100 (2004)

14. Miura, Y., Kataoka, H., Joh, T., Tada, T., Asai, K., Nakanishi, M., Okada, N., and Okada, H. Susceptibility to killer T cells of gastric cancer cells enhanced by Mitomycin-C involves induction of ATBF1 and activation of p21(Waf1/Cip1) promoter. Microbiol Immunol. 48, 137-145 (2004)

15. Takagi, M., Tsuchida, R., Oguchi, K., Shigeta, T., Nakada, S., Shimizu, K., Ohki, M., Delia, D., Chessa, L., Taya, Y., Nakanishi, M., Tsunematsu, Y., Bessho, F., Isoyama, K., Hayashi, Y., Kudo, K., Okamura, J., and Mizutani, S. Identification and characterization of polymorphic variations of the ataxia telangiectasia mutated (ATM) gene in childhood Hodgkin disease. Blood. 103, 283-290 (2004)

16. Fujita, F., Taniguchi, Y., Kato, T., Narita, Y., Furuya, A., Ogawa, T., Sakurai, H., Joh, T., Itoh, M., Delhase, M., Karin, M., and Nakanishi, M. Identification of NAP1, a regulatory subunit of IkappaB kinase-related kinases that potentiates NF-kappaB signaling. Mol. Cell. Biol. 23, 7780-7793 (2003)

17. Li, S.F., Fujita, F., Hirai, M., Lu, R., Niida, H., and Nakanishi, M. Genomic structure and characterization of the promoter region of the human NAK gene. Gene. 304, 57-64 (2003)

18. Kobayashi, S., Nagino, M., Komatsu, S., Naruse, Kl., Nimura, Y., Nakanishi, M., and Sokabe, M. Stretch-induced IL-6 secretion from endothelial cells requires NF-kappaB activation. Biochem. Biophys. Res. Commun. 308, 306-312 (2003)

19. Ishimi, Y., Komamura, Kohno, Y., Kwon, H.J., Yamada, K., and Nakanishi, M. Identification of MCM4 as a target of the DNA replication block checkpoint system. J. Biol. Chem. 278, 24644-24650 (2003)

20. Hayashi, E., Yasui, A., Oda, K., Nagino, M., Nimura, Y., Nakanishi, M., Motoyama, N., Ikeda, K., and Matsuura, A. Loss of p27(Kip1) accelerates DNA replication after partial hepatectomy in mice. J. Surg. Res. 111, 196-202 (2003)

21. Takai, H., Naka, K., Okada, Y., Watanabe, M., Harada, N., Saito, S., Anderson, C.W., Appela, E., Nakanishi, M., Suzuki, H., Nagashima, K., Sawa, H., Ikeda, K., and Motoyama, N. Chk2-deficient mice exhibit radioresistance and defective p53-mediated transcription. EMBO J. 21, 5195-5205 (2002)

22. Murakami, H., Yanow, S.K., Griffiths, D., Nakanishi, M., and Nurse, P. Maintenance of replication forks and the S-phase checkpoint by Cdc18p and Orp1p. Nature Cell Biol. 4, 384-388 (2002)

23. Kobayashi, Y., Watanabe, M., Okada, Y., Sawa, H., Takai, H., Nakanishi, M., Kawase, Y., Suzuki, H., Nagashima, K., Ikeda, K., and Motoyama, N. Hydrocephalus, Situs Inversus, Chronic Sinusitis, and Male Infertility in DNA Polymerase lambda-Deficient Mice: Possible Implication for the Pathogenesis of Immotile Cilia Syndrome. Mol. Cell. Biol. 22, 2769-2776 (2002)

24. Hashimoto, Y., Akita, H., Hibino, M., Kohri, K., and Nakanishi, M. Identification and characterization of Nek6 protein kinase, a potential human homolog of NIMA histone H3 kinase. Biochem. Biophys. Res. Commun. 293, 753-758 (2002)

25. Ding, X., Mizokami, M., Ge, X., Orito, E., Iino, S., Ueda R., and Nakanishi, M. Different hepatitis B virus genotype distributions among asymptomatic carriers and patients with liver diseases in Nanning, southern China. Hepatology Res. 22, 37-44 (2002)

26. Touitou, R., Richardson, J., Bose, S., Nakanishi, M., Rivett, J., and Allday, M.J. A degradation signal located in the C-terminus of p21WAF1/CIP1 is a binding site for the C8 a-subunit of the 20S proteasome. EMBO J. 20, 2367-2375 (2001)

27. Buscemi, G., Savio, C., Zannini, L., Micciche, F., Masnada, D., Nakanishi, M., Tauchi, H., Komatsu, K., Mizutani, S., Khanna, K.K., Chen, P., Concannon, P., Chessa, L., and Delia, D. Nbs1 dependence of Chk2 activation after DNA-damage. Mol. Cell. Biol. 21, 5214-5222 (2001)

28. Harris, T.E., Albrecht, J.H., Nakanishi, M., and Darlington, G.J. C/EBPa cooperates with p21 to inhibit cdk2 kinase activity and induces growth arrest independent of DNA binding. J. Biol. Chem. 276, 29200-29209 (2001)

29. Yoneda, K., Yamamoto, N., Asai, K., Sobue, K., Fujita, Y., Fujita, M., Mase, M., Yamada, K., Nakanishi, M., Tada, T., Miura, Y., and Kato, T. Regulation of aquaporin-4 expression in astrocytes. Mol. Brain Res. 89, 94-102 (2001)

30. Ding, X., Mizokami, M., Yao, G., Xu, G., Orito, E., Ueda, R., and Nakanishi, M. Hepatitis B virus genotype distribution among chronic hepatitis B virus carriers in Shanghai, China. Intervirology 44, 43-47 (2001)

31. Tojima, Y., Fujimoto, A., Delhase, M., Chen, Y., Hatakeyama, S., Nakayama, K., Kaneko, Y., Nimura, Y., Motoyama, N., Ikeda, K., Karin, M., Nakanishi, M. NAK is an IkB kinase-activating kinase. Nature 404, 778-782 (2000)

32. Takai, H., Tominaga, K., Motoyama, N., Minamishima, Y., Nagahama, H., Tsukiyama, T., Ikeda, K., Nakayama, K., Nakanishi, M., Nakayama, K. Aberrant Cell Cycle Checkpoint Function and Early Embryonic Death in Chk1-/- Mice. Genes & Dev. 14, 1439-1447 (2000)

33. Yamamoto, A., Hashimoto, Y., Kohri, K., Ogata, E., Kato, S., Ikeda, K., Nakanishi, M. Cyclin E as a coactivator of the androgen receptor. J. Cell Biol. 150, 873-879 (2000)

34. Nagasawa, K., Kitamura, K., Yasui, A., Nimura, Y., Ikeda, K., Hirai, M., Matsukage, A., Nakanishi, M. Identification and characterization of human DNA polymerase b2, a DNA polymerase b-related enzyme. J. Biol. Chem. 275, 31233-31238 (2000)

35. Nakanishi, M., Ando, H., Watanabe, N., Kitamura, K., Ito, K., Okayama, H., Miyamoto, T., Agui, T., Sasaki, M. Identification and characterization of human Wee1B, a new member of the Wee1 family of Cdk-inhibitory kinases. Genes to Cells 5, 839-847 (2000)

36. Satoh, T., Furuta, K., Tomokiyo, K., Nakatsuka, D., Tanikawa, M., Nakanishi, M., Miura, M., Tanaka, S., Koike, T., Hatanaka, H., Ikuta, K., Suzuki, M., Watanabe, Y. Facilitatory roles of nevel compounds designed from cyclopentenone prostaglandins on neurie outgrowth-promoting acitivities of nerve growth factor. J. Neurochem. 75, 1092-1102 (2000)

37. Akita, H., Iizuka, A., Hashimoto, Y., Kohri, K., Ikeda, K., Nakanishi, M. Induction of KAI-1 Expression in Metastatic Cancer Cells by Phorbol Esters. Cancer letters 153, 79-83 (2000)

38. Fuse, T., Tanikawa, M., Nakanishi, M., Ikeda, K., Tada, T., Inagaki, H., Asai, K., Kato, T., Yamada, K. p27Kip1 expression by contact inhibition as a prognostic index of human glioma. J. Neurochem. 74, 1393-1399 (2000)

39. Takahashi, H., Menjo, M., Kaneko, Y., Ikeda, K., Matsushime, H., Nakanishi, M. Cdk4 activation is dependent on the subunit rearrangement in the complexes. Biochem. Biophys. Res. Commun. 267, 388-393 (2000)

40. Ogawa, K., Kimoto, N., Asamoto, M., Nakanishi, M., Satoru Takahashi, Tomoyuki Shirai. Aberrant expression of p27Kip1 is associated with malignant transformation of the rat urinary bladder epithelium. Carcinogenesis 21, 117-121 (2000)

41. Morisaki, H., Ando, A., Nagata, Y., Pereira-Smith, O.M., Smith, J.R., Ikeda, K., Nakanishi, M. Complex mechanisms underlying impaired activation of Cdk4 and Cdk2 in replicative senescence: role of p16, p21 and cyclin D1. Exp. Cell Res. 253, 503-510 (1999)

42. Mitsui, K., Nakanishi, M., Ohtsuka, S., Norwood, T.H., Obayashi, K., Miyamoto, C., Tanaka, K., Yoshimura, A., Ohtsubo, M. A novel human gene encoding HECT domain and RCC1-like repeats interacts with cyclins and is potentially regulated by the tumor suppressor proteins. Biochem. Biophys. Res. Commun. 266, 115-122 (1999)

43. Tominaga, K., Morisaki, H., Kaneko, Y., Fujimoto, A., Tanaka, T., Ohtsubo, M., Hirai, M., Okayama, H., Ikeda, K., Nakanishi, M. Role of human Cds1(Chk2) kinase in DNA damage checkpoint and its regulation by p53. J. Biol. Chem. 274, 31463-13467 (1999)

44. Kitamura, K., Takayama, M., Hamajima, N., Nakanishi. M.  et al. Characterization of the Human DRP-2 (dihydropyrimidinase-related protein 2) Gene. DNA Research 6, 291-297 (1999)

45. Kaneko, Y., Ikeda, K., Nakanishi, M. Phorbol ester inhibits DNA damage-induced apoptosis in U937 cells through activation of protein kinase C. Life Science 65, 2251-2258 (1999)

46. Nakanishi, M., Kaneko, Y., Matsuhime, H., Ikeda, K. Direct interaction of p21 cyclin-dependent kinase inhibitor with the retinoblastoma tumor suppressor protein. Biochem. Biophys. Res. Commun. 263, 35-40 (1999)

47. Nakanishi, K., Nakanishi, M., Kukita, F. Dual intracellular recording of neocortical neurons in a neuron-glia co-culture system. Brain Res. Protocol. 4, 105-114 (1999)

48. Kaneko, Y., Watanabe, N., Morisaki, H., Akita, H., Fujimoto, A., Tominaga, K., Tachibana, A., Ikeda, K., and Nakanishi, M. Cell cycle-dependent and ATM-independent expression of human Chk1in mammalian cells. Oncogene 18, 3673-3681 (1999)

49. Yanagisawa, K., Kosaka, A., Iwahana H., Nakanishi, M., and Tominaga, S.-I. Opposite regulations of the expression of cyclin-dependent kinase inhibitors during contact inhibition. J. Biochem. 125, 36-40 (1999)

50. Menjo, M., Kaneko, Y., Ikeda, K., and Nakanishi, M. Critical role for p27Kip1 in cell cycle arrest after androgen depletion in mouse mammary carcinoma cells (SC-3). Oncogene 17, 2619-2627 (1999)

51. Ishikawa, T., Akimaru, K., Nakanishi, M., Tomokiyo K., Furuta, K., Suzuki, M., and Noyori, R. Anticancer prostaglandin-induced cell cycle arrest and its modulation by a GS-X pump inhibitor. Biochemical J. 336, 569-576 (1998)

52. Menjo, M., Ikeda, K., and Nakanishi, M.  Regulation of G1 cyclin-dependent kinases in liver regeneration.  J. Gastro. Hepatol. 13, 100-115 (1998)

53. Tanikawa, M., Yamada, K., Tominaga, K., Morisaki, H., Kaneko, Y., Ikeda, K., Suzuki, M., Kiho, T., Tomokiyo, K., Furuta, K., Noyori, R., and Nakanishi, M. Potent prostaglandin A1 analogs that suppress tumor cell growth through induction of p21 and reduction of cyclin E. J. Biol. Chem.

54. Suzuki, M., Kiho, T., Tomokiyo, K., Furuta, K., Fukushima, S., Takeuchi, Y., Nakanishi, M., and Noyori, R. Rational design of antitumor prostaglandins with high biological stability. J. Med. Chem. 41, 3084-3090 (1998)

55. Hashimoto, Y., Kohri, K., Kaneko, Y., Morisaki, Y., Kato, T., Ikeda, K., and Nakanishi, M.  Critical role for the 310 helix region of p57 in Cdk2 inhibition and growth suppression. J. Biol. Chem. 273, 16544-16550 (1998)

56. Akimaru, K., Nakanishi, M., Suzuki, M., Furuta, K., Noyori, R., and Ishikawa, T. Cell growth inhibition by antitumor prostaglandin and its modulation by MRP/GS-X pump. Adv. Exp. Med. Biol. 407, 387-391 (1997)

57. Nakanishi, M., Kagawa, Y., Takahashi, H., and Matsushime, H. Two different bindings of p21 CKI to cyclin/Cdk complex. Leukemia 11, 356-357 (1997)

58. Morisaki, H., Fujimoto, A., Ando, A., Nagata, Y., Ikeda, K., and Nakanishi, M. Cell cycle-dependent phosphorylation of p27 cyclin-dependent kinase (Cdk) inhibitor by cyclin E/Cdk2. Biochem. Biophys. Res. Commun. 240, 386-390 (1997)

59. Hashimoto, Y., Kohri, K., Akita, H., Mitani, K., Ikeda, K., and Nakanishi, M. Efficient transfer of genes into senescent cells by adenovirus vectors via highly expressed alpha v beta 5 integrin. Biochem. Biophys. Res. Commun. 240, 88-92 (1997)

60. Fuse, T., Yamada, K., Asai, K., Kato, T., and Nakanishi, M. Heat shock-mediated cell cycle arrest is accompanied by induction of p21 CKI. Biochem. Biophys. Res. Commun. 225, 759-763 (1996)

62. Dimri, G.P., Nakanishi, M., Desprez, P.Y., Smith, J.R., and Campisi, J. Inhibition of E2F activity by the cyclin-dependent protein kinase inhibitor p21 in cells expressing or lacking a functional retinoblastoma protein. Mol Cell Biol 16, 2987-2997 (1996)

63. Timchenko, N.A., Wilde, M. Nakanishi, M., Smith, J.R., and Darlington, G.J. CCAAT/enhancer-binding protein alpha (C/EBP alpha) inhibits cell proliferation through the p21 (WAF-1/CIP-1/SDI-1) protein. Genes Dev. 10, 804-815 (1996)

64. Smith, J.R., Nakanishi, M., Robetorye, R.S., Venable, S.F., and Pereira-Smith, O.M. Studies demonstrating the complexity of regulation and action of the growth inhibitory gene SDI1. Exp. Gerontol. 31, 327-335 (1996)

65. Nakanishi, M., Robetorye, R.S., Pereira-Smith, O.M., and Smith, J.R. The C-terminal region of p21SDI1/WAF1/CIP1 is involved in proliferating cell nuclear antigen binding but does not appear to be required for growth inhibition. J. Biol. Chem. 270, 17060-17063 (1995)

66. Nakanishi, M., Adami, G.R., Robetorye, R.S., Noda, A., Venable, S.F., Dimitrov, D., Pereira-Smith, O.M., and Smith, J.R. Exit from G0 and entry into the cell cycle of cells expressing p21Sdi1 antisense RNA. Proc. Natl. Acad. Sci. 92, 4352-4356 (1995)

67. Nakanishi, M., Robetorye, R.S., Adami, G.R., Pereira-Smith, O.M., and Smith, J.R. Identification of the active region of the DNA synthesis inhibitory gene p21Sdi1/CIP1/WAF1. EMBO J. 14, 555-563 (1995)

68. Nakanishi, M., Kagawa, Y., Narita, Y., and Hirata, H. Purification and reconstitution of an intestinal Na(+)-dependent neutral L-alpha-amino acid transporter. J. Biol. Chem. 269, 9325-9329 (1994)

69. Niwa, K., Yaginuma, A., Nakanishi, M., Wada, Y., Sugo, T., Asakura, S., Watanabe, N., and Matsuda, M. Fibrinogen Mitaka II: a hereditary dysfibrinogen with defective thrombin binding caused by an A alpha Glu-11 to Gly substitution. Blood 82, 3658-3663 (1993)

70. Nakanishi, M., Tetsuka, T., Kagawa, Y., Moriyama, A., Sasaki, M., and Hirata, H. Solubilization and reconstitution of high- and low-affinity Na(+)-dependent neutral L-alpha-amino acid transporters from rabbit small intestine. Biochim. Biophys. Acta. 1151, 193-200 (1993)

71. Wada, Y., Niwa, K., Maekawa, H., Asakura, S., Sugo, T., Nakanishi, M., Auerswald, G., Popp, M., and Matsuda, M. A new type of congenital dysfibrinogen, fibrinogen Bremen, with an A alpha Gly-17 to Val substitution associated with hemorrhagic diathesis and delayed wound healing. Thromb Haemost. 70, 397-403 (1993)

72. Matsuda, C., Endo, H., Hirata, H., Morosawa, H., Nakanishi, M., and Kagawa, Y. Tissue-specific isoforms of the bovine mitochondrial ATP synthase gamma-subunit. FEBS Lett. 325, 281-284 (1993)

73. Yamasaki, S., Nakanishi, M., Hamamoto, T., Hirata, H., Ebihara, A., Tokue, A., and Kagawa, Y. Expression of human metallothionein-II fusion protein in Escherichia coli. Biochem. Int. 28, 451-460 (1992)

74. Ohta, T., Noguchi, S., Nakanishi, M., Mutoh, Y., Hirata, H., Kagawa, Y., and Kawamura, M. The 'lysine cluster' in the N-terminal region of Na+/K(+)-ATPase alpha-subunit is not involved in ATPase activity. Biochim. Biophys. Acta. 1059, 157-164 (1991)

75. Sasaki, M., Nakanishi, M., and Moriyama, A. Human liver aminopeptidase M and its regulation by bile acids. Biol. Chem. Hoppe. Seyler. 371, 321-326 (1990)

76. Narita, Y., Moriyama, A., Nakanishi, M., Hayakawa, T., Katagiri, K., and Sasaki, M. A novel diisopropylphosphofluoridate-sensitive phenylalanine arylamidase in human liver. Biochem. Int. 20, 89-98 (1990)

77. Nakanishi, M., Moriyama, A., Narita, Y., and Sasaki, M. Aminopeptidase M from human liver. II. Kinetic analysis of inhibition of the enzyme by bile acids. J. Biochem. 106, 826-830 (1989)

78. Nakanishi, M., Moriyama, A., Narita, Y., and Sasaki, M. Aminopeptidase M from human liver. I. Solubilization, purification, and some properties of the enzyme. J. Biochem. 106, 818-825 (1989)

79. Moriyama, A., Nakanishi, M., Takenaka. O., and Sasaki, M. Porcine muscle prolyl endopeptidase: limited proteolysis of tryptic peptides from hemoglobin beta-chains at prolyl and alanyl bonds. Biochim. Biophys. Acta. 956, 151-155 (1988)

80. Moriyama, A., Nakanishi, M., and Sasaki, M. Porcine muscle prolyl endopeptidase and its endogenous substrates. J. Biochem. 104, 112-117 (1988)

81. Nakanishi, M., Hirata, H., Moriyama, A., Kagawa, Y., and Sasaki, M. Partial purification of alanine carrier from rabbit small intestine brush border membrane and its functional reconstitution into proteoliposomes. Biochem. Biophys. Res. Commun. 152, 1158-1164 (1988)


273, 18522-18527 (1998)