List of Publications

Main Publications

    Listed here

2023

  1. Transcriptomic characterization of Lonrf1 at the single-cell level under pathophysiological conditions. Dan Li, Teh-Wei Wang, Sae Aratani, Satotaka Omori, Maho Tamatani, Yoshikazu Johmura, Makoto Nakanishi. J Biochem.2023 Mar 8;mvad021. doi: 10.1093/jb/mvad021.

    2022

    1. The termination of UHRF1-dependent PAF15 ubiquitin signaling is regulated by USP7 and ATAD5. Ryota Miyashita, Atsuya Nishiyama, Yoshie Chiba, Satomi Kori, Norie Kato, Chieko Konishi, Soichiro Kumamoto, Hiroko Kozuka-Hata, Masaaki Oyama, Yoshitaka Kawasoe, Toshiki Tsurimoto, Tatsuro S Takahashi, Kyohei Arita, Makoto Nakanishi. eLife. 2022 May 30. doi:10.1101/2022.05.30.494002.
    2. Blocking PD-L1-PD-1 improves senescence surveillance and ageing phenotypes. Teh-Wei Wang, Yoshikazu Johmura, Narumi Suzuki, Satotaka Omori, Toshiro Migita, Kiyoshi Yamaguchi, Seira Hatakeyama, Satoshi Yamazaki, Eigo Shimizu, Seiya Imoto, Yoichi Furukawa, Akihiko Yoshimura, Makoto Nakanishi. Nature. 2022 Nov;611(7935):358-364. doi: 10.1038/s41586-022-05388-4.

      2021

      1. Johmura Y, Yamanaka T, Omori S, Wang TW, Sugiura Y, Matsumoto M, Suzuki N, Kumamoto S, Yamaguchi K, Hatakeyama S, Takami T, Yamaguchi R, Shimizu E, Ikeda K, Okahashi N, Mikawa R, Suematsu M, Arita M, Sugimoto M, Nakayama KI, Furukawa Y, Imoto S, Nakanishi M. Senolysis by glutaminolysis inhibition ameliorates various age-associated disorders. Science. 2021 Jan 15;371(6526):265.
        [Abstract]. [Reprint]. [Full text].
      2. A 3D tissue model-on-a-chip for studying the effects of human senescent fibroblast on blood vessels. Pauty J, Nakano S, Usaba R, Nakajima T, Johmura Y, Omori S, Sakamoto N, Kikuchi A, Nakanishi M, Matsunaga YT. Biomater Sci. 2021 Jan 5;9(1):199-211. doi:10.1039/d0bm01297a
      3. TP53/p53-FBXO22-TFEB controls basal autophagy to govern hormesis. Suzuki N, Johmura Y, Wang TW, Migita T, Wu W, Noguchi R, Yamaguchi K, Furukawa Y, Nakamura S, Miyoshi I, Yoshimori T, Ohta T, Nakanishi M. Autophagy 2021 Mar 11:1-18. doi:10.1080/15548627.2021.1897961.
      4. HPF1-dependent PARTP activation promotes LIG3-XRCC1-mediated backup pathway of Okazaki fragment ligation. Kumamoto S, Nishiyama A, Chiba Y, Miyashita R, Konishi C, Azuma Y, Nakanishi M. Nucleic Acids Res. 2021 Apr 19:gkab269.doi:10.1093/nar/gkab269.
      5. Navigating the DNA methylation landscape of cancer. Nishiyama A, Nakanishi M. Trends Genet. 2020 Jun 10:S0168-9295(21)00130-X. doi:10.1016/j.tig.2021.05.002.

      2020

      1. Two distinct modes of DNMT1 recruitment ensure stable maintenance DNA methylation. Nishiyama A, Mulholland CB, Bultmann S, Kori S, Endo A, Saeki Y, Qin W, Trummer C, Chiba Y, Yokoyama H, Kumamoto S, Kawakami T, Hojo H, Nagae G, Aburatani H, Tanaka K, Arita K, Leonhardt H, Nakanishi M. Nat Commun. 2020 Mar 6;11(1):1222. doi: 10.1038/s41467-020-15006-4.
      2. Enhanced processivity of Dnmt1 by mono-ubiquitinated histone H3. Mishima Y, Brueckner L, Takahashi S, Kawakami T, Otani J, Shinohara A, Takeshita K, Garvilles RG, Watanabe M, Sakai N, Takeshima H, Nachtegael C, Nishiyama A, Nakanishi M, Arita K, Nakashima K, Hojo H, and Suetake I. Genes Cells 2020 Jan;25(1):22-32. doi: 10.1111/gtc.12732. Epub 2019 Dec 3.
      3. FBXO22, an epigenetic multiplayer coordinating senescence, hormone signaling, and metastasis. Yoshikazu Johmura , Alexander S Harris, Tomohiko Ohta, Makoto Nakanishi Cancer Sci. 2020 Jun 14;111(8):2718-2725. doi: 10.1111/cas.14534
      4. Synthetic hyperacetylation of nucleosomal histones. Hidetoshi Kajino, Tomomi Nagatani, Miku Oi, Tomoya Kujirai, Hitoshi Kurumizaka, Atsuya Nishiyama, Makoto Nakanishi, Kenzo Yamatsugu, Shigehiro A. Kawashima, and Motomu Kanai RSC Chem Biol. 2020 May 19
      5. Generation of a p16 Reporter Mouse and Its Use to Characterize and Target p16 high Cells In Vivo. Omori S, Wang TW, Johmura Y, Kanai T, Nakano Y, Kido T, Susaki EA, Nakajima T, Shichino S, Ueha S, Ozawa M, Yokote K, Kumamoto S, Nishiyama A, Sakamoto T, Yamaguchi K, Hatakeyama S, Shimizu E, Katayama K, Yamada Y, Yamazaki S, Iwasaki K, Miyoshi C, Funato H, Yanagisawa M, Ueno H, Imoto S, Furukawa Y, Yoshida N, Matsushima K, Ueda HR, Miyajima A, Nakanishi M. Cell Metab. 2020 Sep 11:S1550-4131(20)30484-8. doi: 10.1016/j.cmet.2020.09.006. Epub ahead of print. PMID: 32949498.

      2019

      1. Cellular senescence and age-related diseases. Nakanishi M. Ringshio Ketsueki 2019;60(9):1027-1032. doi: 10.11406/rinketsu.60.1027.Risho Ketsueki.
      2. Isozyme-Specific Role of SAD-A in Neuronal Migration During Development of Cerebral Cortex. Nakanishi, K., Niida, H., Tabata, H., Ito, T., Hori, Y., Hattori, M., Johmura, Y., Yamada, C., Ueda, T., Takeuchi, K., Yamada, K., Nagata, KI., Wakamatsu, N., Kishi, M., Pan YA., Ugawa, S., Shimada, S., Sanes, JR., Higashi, Y., Nakanishi, M. Cereb Cortex 29(9):3738-3751(2019)
      3. Cdk1-mediated DIAPH1 phosphorylation maintains metaphase cortical tension and inactivates the spindle assembly checkpoint at anaphase. Nishimura K, Johmura Y, Deguchi K, Jiang Z, Uchida KSK, Suzuki N, Shimada M, Chiba Y, Hirota T, Yoshimura SH, Kono K, Nakanishi M. Nat Commun. 10(1):981.(2019)

      2018

      1. Fbxo22-mediated KDM4B degradation determines selective estrogen receptor modulator activity in breast cancer. Yoshikazu Johmura, Ichiro Maeda, Narumi Suzuki, Wenwen Wu, Atsushi Goda, Mariko Morita, Kiyoshi Yamaguchi, Mizuki Yamamoto, Satoi Nagasawa, Yasuyuki Kojima, Koichiro Tsugawa, Natsuko Inoue, Yasuo Miyoshi, Tomo Osako, Futoshi Akiyama, Reo Maruyama, Jun-ichiro Inoue, Yoichi Furukawa, Tomohiko Ohta, and Makoto Nakanishi. J Clin Invest. 2018 Dec 3;128(12):5603-5619. doi: 10.1172/JCI121679. PMID: 30418174

      2017

      1. Structure of the Dnmt1 Reader Module Complexed with a Unique Two-Mono-Ubiquitin Mark on Histone H3 Reveals the Basis for DNA Methylation Maintenance. Ishiyama S, Nishiyama A, Saeki Y, Moritsugu K, Morimoto D, Yamaguchi L, Arai N, Matsumura R, Kawakami T, Mishima Y, Hojo H, Shimamura S, Ishikawa F, Tajima S, Tanaka K, Ariyoshi M, Shirakawa M, Ikeguchi M, Kidera A, Suetake I, Arita K, Nakanishi M. Mol Cell. 2017 Oct 19;68(2):350-360.e7. doi: 10.1016/j.molcel.2017.09.037. PMID:29053958
      2. Exon 7 splicing variant of estrogen receptor α is associated with pathological invasiveness in smoking-independent lung adenocarcinoma. Suzuki A, Okuda K, Yano M, Oda R, Sakane T, Kawano O, Haneda H, Moriyama S, Nakanishi M, Nakanishi R. Oncol Lett. 2017 Jul;14(1):891-898. doi: 10.3892/ol.2017.6216. Epub 2017 May 19.PMID:28693248
      3. The G2 checkpoint inhibitor CBP-93872 increases the sensitivity of colorectal and pancreatic cancer cells to chemotherapy. Iwata T, Uchino T, Koyama A, Johmura Y, Koyama K, Saito T, Ishiguro S, Arikawa T, Komatsu S, Miyachi M, Sano T, Nakanishi M, Shimada M. PLoS One. 2017 May 30;12(5):e0178221. doi: 10.1371/journal.pone.0178221. eCollection 2017. PMID:28558031
      4. Usp7-dependent histone H3 deubiquitylation regulates maintenance of DNA methylation. Yamaguchi L, Nishiyama A, Misaki T, Johmura Y, Ueda J, Arita K, Nagao K, Obuse C, Nakanishi M. Sci Rep. 2017 Dec;7(1):55. doi: 10.1038/s41598-017-00136-5. Epub 2017 Mar 3. PMID: 28246399
      5. A combination of genetic and biochemical analyses for the diagnosis of PI3K-AKT-mTOR pathway-associated megalencephaly. Negishi Y, Miya F, Hattori A, Johmura Y, Nakagawa M, Ando N, Hori I, Togawa T, Aoyama K, Ohashi K, Fukumura S, Mizuno S, Umemura A, Kishimoto Y, Okamoto N, Kato M, Tsunoda T, Yamasaki M, Kanemura Y, Kosaki K, Nakanishi M, Saitoh S. BMC Med Genet. 2017 Jan 13;18(1):4. doi: 10.1186/s12881-016-0363-6. PMID: 28086757

      2016

      1. Johmura, Y., Yamashita, E., Shimada, M., Nakanishi, K., and Nakanishi, M. Defective DNA repair increases susceptibility to senescence through extension of Chk1-mediated G2 checkpoint activation. Sci Rep. in press
      2. Wu, W., Togashi, Y., Johmura, Y., Miyoshi, Y., Nobuoka, S., Nakanishi, M., and Ohta, T. HP1 regulates the localization of FANCJ at sites of DNA double-strand breaks. Cancer Sci. in press.
      3. Kono, K., Al-Zain, A., Schroeder, L., Nakanishi, M., and Ikui, A.E. Plasma membrane/cell wall perturbation activates a novel cell cycle checkpoint during G1 in Saccharomyces cerevisiae. Proc Natl Acad Sci. 113, 6919-6915 (2016)
      4. Shimada, M., Goshima, T., Matsuo, H., Johmura, Y., Haruta, M., Murata, K., Tanaka, H., Ikawa, M., Nakanishi, K., and *Nakanishi, M. Essential role of auto-activation circuitry on Aurora B-mediated H2AX-pS121 in mitosis. Nature Communications 7, 12059 (2016)
      5. Sharif J, Endo TA, Nakayama M, Karimi MM, Shimda M, Katsuyama K, Goyal P, Brind'Amour J, Sun M-A, Sun Z, Ishikura T, Mizutani-Koseki Y, Ohara O, Shinkai Y, Nakanishi M, Xie H, Lorincz MC, and Koseki H. Protracted NP95 binding to hemimethylated DNA disrupts SETDB1-mediated proviral silencing. Cell Stem Cell in press.
      6. Johmura, Y., Sun, J., Kitagawa, K., Nakanishi, K., Kuno, T., Naiki-Ito, A., Sawada, Y., Miyamoto, T., Okabe, A., Aburatani, H., ShengFan, Li., Miyoshi, I., Takahashi, S., Kitagawa, M., and *Nakanishi, M. SCFFbxo22-KDM4A targets methylated p53 for degradation and regulates senescence. Nature Communications7, 10574 (2016)
      7. Misaki T, Yamaguchi L, Sun J, Orii M, Nishiyama A, Nakanishi M. The replication foci targeting sequence (RFTS) of DNMT1 functions as a potent histone H3 binding domain regulated by autoinhibition. Biochem Biophys Res Commun. 470(3):741-7.・2016
      8. Orii M, Kono K, Wen HI, Nakanishi M. PP1-Dependent Formin Bnr1 Dephosphorylation and Delocalization from a Cell Division Site. PLoS One. 11・e0146941・2016　
      9. Haruta M, Shimada M, Nishiyama A, Johmura Y, Le Tallec B, Debatisse M, Nakanishi M. Loss of maintenance DNA methylation results in abnormal DNA origin firing during DNA replication. Biochem Biophys Res Commun. 469・960-6・2016　
      10. Nishiyama A, Yamaguchi L, Nakanishi M. Regulation of maintenance DNA methylation via histone ubiquitylation. J Biochem. 159・9-15・2016　

      2015

      1. Murata K, Sato S, Haruta M, Goshima T, Chiba Y, Takahashi S, Sharif J, Koseki H, Nakanishi M, Shimada M.Physical interaction between MPP8 and PRC1 complex and its implication for regulation of spermatogenesis. Biochem Biophys Res Commun. 458:470-5. 2015
      2. Nakanishi M. [Mechanisms of maintaining genomic and epigenomic integrities]. Seikagaku. 87・165-75・2015

      2014

      1. Johmura Y, Shimada M, Misaki T, Naiki-Ito A, Miyoshi H, Motoyama N, Ohtani N, Hara E, Nakamura M, Morita A, Takahashi S, Nakanishi M. Necessary and sufficient role for a mitosis skip in senescence induction. Mol Cell.55:73-84. 2014
      2. Asano E, Ebara T, Yamada-Namikawa C, Kitaori T, Suzumori N, Katano K, Ozaki Y, Nakanishi M, Sugiura-Ogasawara M. Genotyping Analysis for the 46 C/T Polymorphism of Coagulation Factor XII and the Involvement of Factor XII Activity in Patients with Recurrent Pregnancy Loss.PLoS One. 9:e114452. 2014
      3. CBP-93872 inhibits NBS1-mediated ATR activation, abrogating maintenance of the DNA double-strand break-specific G2 checkpoint. Hirokawa T, Shiotani B, Shimada M, Murata K, Johmura Y, Haruta M, Tahara H, Takeyama H, Nakanishi M.　Cancer Res. 74:3880-9. 2014
      4. Mutational analysis of FOXL2 p.C134W and expression of bone morphogenetic protein 2 in Japanese patients with granulosa cell tumor of ovary. Oseto K, Suzumori N, Nishikawa R, Nishikawa H, Arakawa A, Ozaki Y, Asai H, Kawai M, Mizuno K, Takahashi S, Shirai T, Yamada-Namikawa C, Nakanishi M, Kajiyama H, Kikkawa F, Sugiura-Ogasawara M.　J Obstet Gynaecol Res. 40:1197-204. 2014
      5. Mammal-specific H2A variant, H2ABbd, is involved in apoptotic induction via activation of NF-κB signaling pathway.　 Goshima T, Shimada M, Sharif J, Matsuo H, Misaki T, Johmura Y, Murata K, Koseki H, Nakanishi M. J Biol Chem. 289:11656-66. 2014

      2013

      1. Uhrf1-dependent H3K23 ubiquitylation couples maintenance DNA methylation and replication. Nishiyama A, Yamaguchi L, Sharif J, Johmura Y, Kawamura T, Nakanishi K, Shimamura S, Arita K, Kodama T, Ishikawa F, Koseki H, Nakanishi M. Nature 502:249-53. 2013
      2. Cloning and functional characterization of Ptpcd2 as a novel cell cycle related protein tyrosine phosphatase that regulates mitotic exit. Zineldeen DH, Wagih AA, Nakanishi M. Asian Pac J Cancer Prev. 14:3669-76. 2013
      3. Increased protein stability of CDKN1C causes a gain-of-function phenotype in patients with IMAGe syndrome. Hamajima N, Johmura Y, Suzuki S, Nakanishi M, Saitoh S. PLoS One. 8:e75137. 2013
      4. Involvement of ribonucleotide reductase-M1 in 5-fluorouracil induced DNA damage in esophageal cancer cell lines. Aoki Y, Sakogawa K, Hihara J, Emi M, Hamai Y, Kono K, Shi L, Sun J, Kitao H, Ikura T, Niida H, Nakanishi M, Okada M, Tashiro S. Int J Oncol. 42:1951-60. 2013

      2012

      1. TANK-binding kinase 1(TBK1) controls cell survival through PAI-2/serpinB2 and transglutaminase 2. Delhase M, Kim SY, Lee H, Naiki-Ito A, Chen Y, Ahn ER, Murata K, Kim SJ, Lautsch N, Kobayashi KS, Shirai T, Karin M, Nakanishi M. Proc Natl Acad Sci USA. 109:E177-86. 2012
      2. Chk1 phosphorylates the tumour suppressor　Mig-6, regulating the activation of EGF signalling. Liu N, Matsumoto M, Kitagawa K, Kotake Y, Suzuki S, Shirasawa S, Nakayama KI, Nakanishi M, Niida H, Kitagawa M. EMBO J. 31:2365-77. 2012
      3. Histone H1 expression in human prostate cancer tissues and cell lines. Sato S, Takahashi S, Asamoto M, Nakanishi M, Wakita T, Ogura Y, Yatabe Y, Shirai T. Pathol Int. 62:84-92. 2012

      2011

      1. Nuclear Chk1 prevents premature mitotic entry. Matsuyama M, Goto H, Kasahara K, Kawakami Y, Nakanishi M, Kiyono T, Goshima N,Inagaki M. J Cell Sci. 124(Pt 13):2113-9. 2011
      2. Genetic variation of the IL-28B promoter affecting gene expression. Sugiyama M, Tanaka Y, Wakita T, Nakanishi M, Mizokami M. PLoS One. 6:e26620. 2011
      3. Organ differences in　the impact of p27(kip1) deficiency on carcinogenesis induced by　N-methyl-N-nitrosourea. Ogawa K, Murasaki T, Sugiura S, Nakanishi M, Shirai T. J Appl Toxicol. 33:471-9. 2011
      4. Easy-to-use phylogenetic analysis system for hepatitis B virus infection. Sugiyama M, Inui A, Shin-I T, Komatsu H, Mukaide M, Masaki N, Murata K, Ito K,　Nakanishi M, Fujisawa T, Mizokami M. Hepatol Res. 41:936-45. 2011
      5. Identification of a checkpoint modulator with　synthetic lethality to p53 mutants. Harada N, Watanabe Y, Yoshimura Y, Sakumoto H, Makishima F, Tsuchiya M, Nakanishi K, Nakanishi M, Aoki Y. Anticancer Drugs. 22:986-94. 2011
      6. SYCP3 mutation may not be associated with recurrent　miscarriage caused by aneuploidy. Mizutani E, Suzumori N, Ozaki Y, Oseto K, Yamada-Namikawa C, Nakanishi M, Sugiura-Ogasawara M. Hum Reprod. 26:1259-66. 2011
      7. Novel findings for the development of drug therapy for various liver diseases: Genetic variation in　IL-28B is associated with response to the therapy for chronic hepatitis C. Sugiyama M, Tanaka Y, Nakanishi M, Mizokami M. J Pharmacol Sci. 115:263-9. 2011

      2010

      1. Shimada, M., Haruta, M., Niida, H., Sawamoto, K., and *Nakanishi, M. PP1g is a phosphatase responsible for dephosphorylation of histone H3 at threonine 11 after DNA damage. EMBO rep. 11, 883-889 (2010)
      2. Niida, H., Shimada, M., Murakami, H., and *Nakanishi, M. Mechanisms of dNTP supply that play an essential role in maintaining genome integrity in eukaryotic cells. Cancer Sci. 101, 2505-2509 (2010)
      3. Niida, H., Murata, K., Shimada, M., Ogawa, K., Ohta, K., Suzuki, K., Fujigaki, H., Khaw, A.K., Banerjee, B., Hande, P.M., Miyamoto, T., Miyoshi, I., Shirai, T., Motoyama, N., Delhase, M., Appella, E., and *Nakanishi, M. Cooperative functions of Chk1 and Chk2 reduce tumor susceptibility in vivo. EMBO J. 29, 3558-3570 (2010)
      4. Murakami, H., Aiba, H., Nakanishi, M., and Murakami-Tonami, Y. Regulation of yeast forkhead transcription factors and FoxM1 by cyclin-dependent and polo-like kinases. Cell Cycle 9, 3233-3242 (2010)
      5. Sakai, S., Ohoka, N., Onozaki, K., Kitagawa, M., Nakanishi, M., and Hayashi, H. Dual mode of regulation of cell division cycle 25A protein by TRB3. Biol Pharm Bull. 33, 1112-1116 (2010)
      6. Niida, H., Katsuno, Y., Sengoku, M., Shimada, M., Yukawa, M., Ikura, M., Ikura, T., Kohno, K., Shima, H., Suzuki, H., Tashiro, S., and *Nakanishi, M. Essential role of Tip60-dependent recruitment of ribonucleotide reductase at DNA damage sites in DNA repair during G1 phase. Genes and Dev. 24, 333-338 (2010)
      7. Ohoka, N., Sakai, S., Onozaki, K., Nakanishi, M., and Hayashi, H. Anaphase promoting complex/cyclosome-cdh1 mediates the ubiquitination and degradation of TRB3. Biochem. Biophys. Res. Commun. 392, 289-294 (2010)
      8. *Nakanishi, M., Katsuno, Y., Niida, H., Murakami, H., and Shimada, M. Regulation of origin firing program in mammals through Chk1-cyclin A/Cdk1 axis.Chromosomal Res. 18, 103-113 (2010)

      2009

      1. *Nakanishi, M., Niida, H., Murakami, H., and Shimada, M. DNA damage responses in skin biology-Implications in tumor prevention and aging acceleration. J Dermatol Sci. 56, 76-81 (2009)
      2. Shimada, M., Yamamoto, A., Murakami-Tonami, Y., Nakanishi, M., Yoshida, T., Aiba, H., and Murakami, H. Casein kinase II is required for the spindle assembly checkpoint by regulating Mad2p in fission yeast. Biochem. Biophys. Res. Commun. 388, 529-532 (2009)
      3. Zineldeen, D.H., Shimada, M., Niida, H., Katsuno, Y., and *Nakanishi, M. Ptpcd-1 is a novel cell cycle related phosphatase that regulates centriole duplication and cytokinesis. Biochem. Biophys. Res. Commun. 380, 460-466 (2009)
      4. Nishizuka, M., Kishimoto, K., Kato, A., Ikawa, M., Okabe, M., Sato, R., Niida, H., Nakanishi, M., Osada, S., and Imagawa, M. Disruption of the novel gene fad14 causes rapid postnatal death and attenuation of cell proliferation, adhesion, spreading and migration. Exp. Cell Res. 315, 809-819 (2009)
      5. Katsuno, Y., Suzuki, A., Sugimura, K., Okumura, K., Zineldeen, D.H., Shimada, M., Niida, H., Mizuno, T., Hanaoka, F., and Nakanishi, M. Cyclin A-Cdk1 regulates the origin firing program in mammalian cells. Proc. Natl. Acad. Sci. 106, 3184-3189 (2009)

      2008

      1. Nagata, D., Hashimoto, Y., Nakanishi, M., Naruyama, H., Okada, S., Ando, R., Tozawa, K., and Kohri, K. Peroxisome proliferator-activated receptor-gamma and growth inhibition by its ligands in prostate cancer. Cancer Detect Prev.32, 259-266 (2008)
      2. Naruyama, H., Shimada, M., Niida, H., Zineldeen, D.H., Hashimoto, Y., Kohri, K., and Nakanishi, M. Essential role of Chk1 in S phase progression through regulation of RNR2 expression. Biochem. Biophys. Res. Commun. 374, 79-83 (2008)
      3. Shimada, M. and Nakanishi, M. Checkpoints meet transcription at a novel histone milestone (H3-T11). Cell Cycle 7, 1555-1559 (2008).。
      4. Hikosaka, A., Ogawa, K., Sugiura, S., Asamoto, M., Takeshita, F., Sato, S.Y., Nakanishi, M., Kohri, K., and Shirai, T. Susceptibility of p27 kip1 knockout mice to urinary bladder carcinogenesis induced by N-butyl-N-(4-hydroxybutyl)nitrosamine may not simply be due to enhanced proliferation. Int. J. Cancer122, 1222-1228 (2008)
      5. Shimada, M., Niida, H., Zineldeen, D.H., Tagami, H., Tanaka, M., Saito, H., and Nakanishi, M. Chk1 is a histone H3 threonine 11 kinase that regulates DNA damage-induced transcriptional repression. Cell 132, 221-232 (2008)
      6. Shimada, M., Yamada-Namikawa, C., Murakami-Tonami, Y., Yoshida, T., Nakanishi, M., Urano, T., and Murakami, H. Cdc2p controls the forkhead transcription factor Fkh2 by phosphorylation during sexual differentiation in fission yeast. EMBO J. 27, 132-142 (2008)

      2007

      1. Murakami-Tonami, Y., Yamada-Namikawa, C., Tochigi, A., Hasegawa, N., Kojima, H., Kunimatsu, M., Nakanishi, M., and Murakami, H., Mei4p coordinates the onset of meiosis I by regulating cdc25+ in fission yeast. Proc. Natl. Acad. Sci. 104, 14688-14693 (2007)
      2. Niida, H., Katsuno, Y., Prakash, H.M., and Nakanishi, M. Specific role of Chk1 phosphorylation in cell survival and checkpoint activation. Mol Cell Biol. 27, 2572-2581 (2007)
      3. Iguchi, T., Miyakawa Y, Saito, K., Nakabayashi, C., Nakanishi, M., Saya, H., Ikeda, Y., and Kizaki, M. Zoledronate-induced S phase arrest and apoptosis accompanied by DNA damage and activation of the ATM/Chk1/cdc25 pathway in human osteosarcoma cells. Int. J. Oncol. 31, 285-291 (2007)
      4. Nakazato, T., Nakanishi, M., Kita, S., Okuyama, F, Shibamoto, Y., and Otsuka, T. J. Radiat. Res. 48, 153-161 (2007)

      Before 2006

        ~2006