Department of Rheumatology and Allergy(Est.2001)
Division of Rheumatology (Est.2013),Center forAbtibody and Vaccine Therapy
東京大学医科学研究所附属病院
アレルギー免疫科 (2001年設置) / 抗体・ワクチンセンター 免疫病治療学分野 (2013年設置)
 
 

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▶︎ 欧文国際雑誌に掲載した原著論文
 

▶︎ 欧文国際雑誌に掲載した原著論文
 

2018

Yuki Usui Yasumasa Kimura Takeshi Satoh Naoki Takemura Yasuo Ouchi Hiroko Ohmiya Kyosuke Kobayashi Hiromi Suzuki Satomi Koyama Satoko Hagiwara Hirotoshi Tanaka Seiya Imoto Gérard Eberl Yukio Asami Kosuke Fujimoto Satoshi Uematsu
Effects of long-term intake of a yogurt fermented with Lactobacillus delbrueckii subsp. bulgaricus 2038 and Streptococcus thermophilus 1131 on mice
Int Immunol. 2018 May 15;dxy035. doi:10.1093/intimm/dxy035


Hiroki Yamazaki, Akifumi Kushiyama, Hideyuki Sakoda, Midori Fujishiro, Takeshi Yamamotoya, Yusuke Nakatsu, Takako Kikuchi, Sunao Kaneko, Hirotoshi Tanaka and Tomoichiro Asano
Protective effect of sex hormone-binding globulin against metabolic syndrome: in vitro evidence showing anti-inflammatory and lipolytic effects on adipocytes and macrophages
Mediators of Inflammation, accepted


Kotaro Anan, Shinjiro Hino, Noriaki Shimizu, Akihisa Sakamoto, Katsuya Nagaoka, Ryuta Takase, Kensaku Kohrogi, Hirotaka Araki, Yuko Hino, Shingo Usuki, Shinya Oki, Hirotoshi Tanaka, Kimitoshi Nakamura, Fumio Endo, Mitsuyoshi Nakao
LSD1 mediates metabolic reprogramming by glucocorticoids during myogenic differentiation
Nucleic Acid Res, 2018 Mar 29;gky234. doi:10.1093/nar/gky234

2017

Hirotoshi Tanaka, Noriaki Shimizu, Noritada Yoshikawa
Role of skeletal muscle glucocorticoid receptor in systemic energy homeostasis.
Exp Cell Res. 2017 Nov 1;360(1):24-26. doi:10.1016/j.yexcr.2017.03.049


Naoki Ito, Isao Kii, Noriaki Shimizu, Hirotoshi Tanaka and Shin’ichi Takeda
Direct reprogramming of fibroblasts into skeletal muscle progenitor cells by transcription factors enriched in undifferentiated subpopulation of satellite cells.
Sci Rep. 2017 Aug 14;7(1):8097. doi:10.1038/s41598-017-08232-2


Toshiki Eri, Kimito Kawahata, Takeyuki Kanzaki, Mitsuru Imamura, Kazuya Michishita, Lisa Akahira, Ei Bannai, Noritada Yoshikawa, Yasumasa Kimura, Takeshi Satoh, Satoshi Uematsu, Hirotoshi Tanaka, and Kazuhiko Yamamoto
Intestinal microbiota link lymphopenia to murine autoimmunity via PD-1+CXCR5-/dim B-helper T cell induction.
Sci Rep. 2017;7:46037.doi:10.1038/srep46037


Ono T, Kamimura N, Matsuhashi T, Nagai T, Nishiyama T, Endo J, Hishiki T, Nakanishi T, Shimizu N, Tanaka H, Ohta S, Suematsu M, Ieda M, Sano M, Fukuda K, Kaneda R.
The histone 3 lysine 9 methyltransferase inhibitor chaetocin improves prognosis in a rat model of high salt diet-induced heart failure.
Sci Rep. 2017 Jan 4;7:39752. doi:10.1038/srep39752


Erika Matsubara, Noritada Yoshikawa, Osamu Hosono, Hiroyuki Baba, Toshiki Eri, Masaaki Uehara, Aya Oda, Chieko Sekita, Atsuo Taniguchi, Hirotoshi Tanaka
A rheumatoid arthritis patient complicated with adenine phosphoribosyltransferase deficiency and unilateral renal agenesis: a first case report.
Modern Rheumatology Case Reports. 2017 Jan;1:1. 15-19. doi:10.1080/24725625.2016.1266729


Yoshikawa N, Shimizu N, Uehara M, Oda Y, Matsumiya R, Matsubara E, Kobayashi H, Hosono O, Kuribara-Souta A, Baba H, Nagamura F, Kiryu S, Tanaka H.
The effects of bolus supplementation of branched-chain amino acids on skeletal muscle mass, strength, and function in patients with rheumatic disorders during glucocorticoid treatment.
Mod Rheumatol. 2017 May;27(3):508-517. doi: 10.1080/14397595.2016.1213480

2016

Ito N, Shimizu N, Tanaka H, Takeda S.
Enhancement of Satellite Cell Transplantation Efficiency by Leukemia Inhibitory Factor.
J Neuromuscul Dis. 3:201-207, 2016.


Kobayashi H, Uehara M, Oda A, Matsubara E, Baba H, Matsumiya R, Yoshikawa N, Hosono O, Tanaka H.
Normal pressure hydrocephalus, a possible complication in IgG4-related disease. Interdisciplinary Neurosurgery. 5:1-2, 2016.


 Ishii H, Konuma T, Ohnuma K, Hosono O, Tanaka H, Kato S, Tojo A, Takahashi S.
Remission of remitting seronegative symmetrical synovitis with pitting edema after unrelated cord blood transplantation for myelodysplastic syndrome.
Ann Hematol. 2016 Feb;95(3):523-4. doi: 10.1007/s00277-015-2555-0. No abstract available.

2015

Tomoki Katayose; Satoshi Iwata; Naoki Oyaizu; Osamu Hosono; Taketo Yamada; Nam H Dang; Ryo Hatano; Hirotoshi Tanaka; Kei Ohnuma; Chikao Morimoto
The Role of Cas-L/NEDD9 as a Regulator of Collagen-induced Arthritis in a Murine Model
Biochem Biophys Res Commun. 2015, 460(4):1069-1075.  DOI:10.1016/j.bbrc.2015.03.156


Shimizu N, Maruyama T, Yoshikawa N, Matsumiya R, Ma Y, Ito N, Tasaka Y, Kuribara-Souta A, Miyata K, Oike Y, Berger S, Schütz G, Takeda S, Tanaka H.
A Muscle-liver-fat signaling axis is essential for central control of adaptive adipose remodeling.
Nat Commun. 6,6693.  doi:10.1038/ncomms7693


Matsumiya R, Hosono O, Yoshikawa N, Uehara M, Kobayashi H, Oda A, Matsubara E, Tanada S, Shintani Y, Nagayama K, Nakajima J, Tanaka H.
A case with elevated serum IgG4 complicated by pericardial involvement with patchy 18F-FDG uptake in PET/CT – atypical presentation of IgG4-related disease?
Internal Med. 54(18), 2337-2341, 2015   DOI  10.2169/internalmedicine.54.4340

2014

Yoshikawa N, Shimizu N, Ojima H, Kobayashi H, Hosono O, and Tanaka H.
Down-regulation of hypoxia-inducible factor-1 alpha and vascular endothelial growth factor by HEXIM1 attenuates myocardial angiogenesis in hypoxic mice.
Biochem Biophys Res Commun. 2014;453(3):600-5.


Miyake Y, Tanaka K, Nishikawa T, Naruse M, Takayanagi R, Sasano H, Takeda Y, Shibata H, Sone M, Satoh F, Yamada M, Ueshiba H, Katabami T, Iwasaki Y, Tanaka H, Tanahashi Y, Suzuki S, Hasegawa T, Katsumata N, Tajima T, Yanase T.
Prognosis of primary aldosteronism in Japan: results from a nationwide epidemiological study.
Endocr J. 61(1):35-40, 2014.


Hosono O, Yoshikawa N (equal first authors), Shimizu N, Uehara M, Kobayashi H, Matsumiya R, Kuribara A, Maruyama T, Tanaka H
Quantitative analysis of skeletal muscle mass in patients with rheumatic diseases under glucocorticoid therapy – comparison among bioelectrical impedance analysis, computed tomography, and magnetic resonance imaging.
Mod Rheumatol. 2015;25(2):257-63

2012

Yoshikawa N, Shimizu N, Maruyama T, Sano M, Matsuhashi T, Fukuda K, Kataoka M, Satoh T, Ojima H, Sawai T, Morimoto C, Kuribara A, Hosono O, Tanaka H. Cardiomyocyte-specific overexpression of HEXIM1 prevents right ventricular hypertrophy in hypoxia-induced pulmonary hypertension in mice.
PLoS One. 2012;7(12):e52522. doi: 10.1371/journal.pone.0052522.


Kondo S, Iwata S, Yamada T, Inoue Y, Ichihara H, Kichikawa Y, Katayose T, Souta-Kuribara A, Yamazaki H, Hosono O, Kawasaki H, Tanaka H, Hayashi Y, Sakamoto M, Kamiya K, Dang NH, and Morimoto C.
Impact of the integrin signaling adaptor protein NEDD9 on prognosis and metastatic behavior of human lung cancer.
Clin. Cancer Res., 2012;18(22):6326-38. doi: 10.1158/1078-0432.CCR-11-2162.

2011

Shimizu N, Yoshikawa N, Ito N, Maruyama T, Suzuki Y, Takeda S, Nakae J, Tagata Y, Nishitani S, Takehana K, Sano M, Fukuda K, Suematsu M, Morimoto C, Tanaka H. Crosstalk between Glucocorticoid Receptor and Nutritional Sensor mTOR in Skeletal Muscle.
Cell Metab. 13(2):170-182, 2011


Mu SY, Shimosawa T, Ogura S, Wang H, Uetake Y, Kawakami-Mori F, Marumo T, Yatomi Y, Geller DS, Tanaka H, Fujita T.
Epigenetic modulation of the renal β-adrenergic–WNK4 pathway in salt-sensitive hypertension.
Nat. Med. 17 (5):573 – 580, 2011


Toyokawa G, Cho H-S, Iwai Y, Yoshimatsu M, Takawa M, Hayami S, Maejima K, Shimizu N, Tanaka H, Tsunoda T, Field H, Kelly J, Neal D, Ponder B, Maehara Y, Nakamura Y, and Hamamoto R.
The histone demethylase JMJD2B plays an essential role in human carcinogenesis through positive regulation of cyclin-dependent kinase 6.
Cancer Prev. Res. 4(12):2051-2061, 2011

2010

Fukazawa T, Maeda Y, Matsuoka J, Ono T, Mominoki K, Yamatsuji T, Shigemitsu K, Morita I, Murakami I, Tanaka H, Durbin ML, Naomoto Y.
Targeting KRAS mutation-bearing lung cancer in vivo by pulmonary surfactant-adenovirus-mediated gene transfer.
Anticancer Res. 30(12):4925-4935, 2010

2009

Fukazawa T, Maeda Y, Matsuoka J, Naomoto Y, Tanaka H, Durbin ML, Tanaka N. Drug-regulatable cancer cell death induced by BID under control of the tissue-specific, lung cancer targeted TTS promoter system.
Int. J. Cancer 125(8):1975-1984, 2009


Yo K, Iwata S, Hashizume Y, Kondo S, Nomura S, Hosono O, Kawasaki H, Tanaka H, Dang NH, Morimoto C.
SHP-2 inhibits tyrosine phosphorylation of Cas-L and regulates cell migration.
Biochem. Biophys. Res. Commun. 382(1):210-214, 2009


Tokudome S, Sano M, Shinmura K, Matsuhashi T, Morizane S, Moriyama H, Tamaki K, Hayashida K, Nakanishi H, Yoshikawa N, Shimizu N, Endo J, Katayama T, Murata M, Yuwasa S, Kaneda R, Tomita K, Eguchi N, Urade Y, Asano K, Utsunomiya Y, Suzuki T, Taguchi R, Tanaka H, Fukuda K.
Glucocorticoid protects rodent hearts from ischemia/reperfusion injury by activating lipocalin-type prostaglandin D synthase–derived PGD2 biosynthesis.
J. Clin. Invest. 119(6):1477-1488, 2009


Yoshikawa N, Nagasaki M, Sano M, Tokudome S, Ueno K, Shimizu N, Imoto S, Miyano S, Suematsu M, Fukuda K, Morimoto C, Tanaka H.
Ligand-based gene expression profiling identifies critical role of glucocorticoid receptor in rat neonatal cardiomyocytes.
Am. J. Physiol. Endocrinol. Metab. 296(6):E1363-1373, 2009

2008

Hozawa S, Nakamura T, Nakano M, Adachi M, Tanaka H, Takahashi Y, Tetsuya M, Miyata N, Soma H, Hibi T.
Induction of matrix metalloproteinase-1 gene transcription by tumour necrosis factor alpha via the p50/p50 homodimer of nuclear factor-kappa B inactivated human hepatic stellate cells.
Liver Int. 28(10):1418-1425, 2008


Shibata S, Nagase M, Yoshida S, Kawarazaki W, Kurihara H, Tanaka H, Miyoshi J, Takai Y, Fujita T.
Modification of mineralocorticoid receptor function by Rac1 GTPase: implication in proteinuric kidney disease.
Nat. Med. 14(12):1370-1376, 2008


Shimizu N, Yoshikawa N, Wada T, Handa H, Sano M, Fukuda K, Suematsu M, Sawai T, Morimoto C, Tanaka H.
Tissue- and context-dependent modulation of hormonal sensitivity of glucocorticoid-responsive genes by hexamethylene bisacetamide-inducible protein 1.
Mol. Endocrinol. 22(12):2609-2623, 2008


Yamochi T, Ohnuma K, Hosono O, Tanaka H, Kanai Y, Morimoto C.
SSA/Ro52 autoantigen interacts with Dcp2 to enhance its decapping activity.
Biochem. Biophys. Res. Commun. 370(1):195-199, 2008


Yoshikawa N, Shimizu N, Sano M, Ohnuma K, Iwata S, Hosono O, Fukuda K, Morimoto C, Tanaka H.
Role of the hinge region of glucocorticoid receptor for HEXIM1-mediated transcriptional repression.
Biochem. Biophys. Res. Commun. 371(1):44-49, 2008


Kagawa T, Watanabe N, Mochizuki K, Numari A, Ikeno Y, Itoh J, Tanaka H, Arias IM, Mine T.
Phenotypic differences in PFIC2 and BRIC2 correlate with protein stability of mutant Bsep and impaired taurocholate secretion in MDCK II cells.
Am. J. Physiol. Gastrointest. Liver Physiol. 294(1):G58-67, 2008


Yamashita T, Ohneda O, Nagano M, Iemitsu M, Makino Y, Tanaka H, Miyauchi T, Goto K, Ohneda K, Fujii-Kuriyama Y, Poellinger L, Yamamoto M.
Abnormal heart development and lung remodeling in mice lacking the hypoxia-inducible factor-related basic helix-loop-helix PAS protein NEPAS.
Mol. Cell. Biol. 28(4):1285-1297, 2008

2007

Sano M, Izumi Y, Helenius K, Asakura M, Rossi DJ, Xie M, Taffet G, Hu L, Pautler RG, Wilson CR, Boudina S, Abel ED, Taegtmeyer H, Scaglia F, Graham BH, Kralli A, Shimizu N, Tanaka H, Makela TP, Schneider MD.
Menage-a-trois 1 is critical for the transcriptional function of PPARgamma coactivator 1.
Cell Metab. 5(2):129-142, 2007


Sano M, Tokudome S, Shimizu N, Yoshikawa N, Ogawa C, Shirakawa K, Endo J, Katayama T, Yuasa S, Ieda M, Makino S, Hattori F, Tanaka H*, Fukuda K* (*, equal last authors).
Intramolecular control of protein stability, subnuclear compartmentalization, and coactivator function of PGC-1alpha.
J. Biol. Chem. 282(35):25970-25980, 2007


Ohnuma K, Uchiyama M, Yamochi T, Nishibashi K, Hosono O, Takahashi N, Kina S, Tanaka H, Lin X, Dang NH, Morimoto C.
Caveolin-1 triggers T-cell activation via CD26 in association with CARMA1.
J. Biol. Chem. 282(13):10117-10131, 2007


Makino Y, Uenishi R, Okamoto K, Isoe T, Hosono O, Tanaka H, Kanopka A, Poellinger L, Haneda M, Morimoto C.
Transcriptional up-regulation of inhibitory PAS domain protein gene expression by hypoxia-inducible factor 1 (HIF-1): a negative feedback regulatory circuit in HIF-1-mediated signaling in hypoxic cells.
J. Biol. Chem. 282(19):14073-14078, 2007


Inamoto T, Yamada T, Ohnuma K, Kina S, Takahashi N, Yamochi T, Inamoto S, Katsuoka Y, Hosono O, Tanaka H, Dang NH, Morimoto C.
Humanized anti-CD26 monoclonal antibody as a treatment for malignant mesothelioma tumors.
Clin. Cancer Res. 13(14):4191-4200, 2007


Inamoto S, Iwata S, Inamoto T, Nomura S, Sasaki T, Urasaki Y, Hosono O, Kawasaki H, Tanaka H, Dang NH, Morimoto C.
Crk-associated substrate lymphocyte type regulates transforming growth factor-beta signaling by inhibiting Smad6 and Smad7.
Oncogene 26(6):893-904, 2007


Fukazawa T, Maeda Y, Durbin ML, Nakai T, Matsuoka J, Tanaka H, Naomoto Y, Tanaka N.
Pulmonary adenocarcinoma-targeted gene therapy by a cancer- and tissue-specific promoter system.
Mol. Cancer. Ther. 6(1):244-252, 2007

2005

Manotham K, Tanaka T, Ohse T, Kojima I, Miyata T, Inagi R, Tanaka H, Sassa R, Fujita T, Nangaku M.
A biologic role of HIF-1 in the renal medulla.
Kidney Int. 67(4):1428-1439, 2005


Yoshikawa N, Yamamoto K, Shimizu N, Yamada S, Morimoto C, Tanaka H.
The distinct agonistic properties of the phenylpyrazolosteroid cortivazol reveal interdomain communication in the glucocorticoid receptor.
Mol. Endocrinol. 19(5):1110-1124, 2005


Iwata S, Souta-Kuribara A, Yamakawa A, Sasaki T, Shimizu T, Hosono O, Kawasaki H, Tanaka H, Dang NH, Watanabe T, Arima N, Morimoto C.
HTLV-I Tax induces and associates with Crk-associated substrate lymphocyte type (Cas-L).
Oncogene. 24(7):1262-1271, 2005


Sasaki T, Iwata S, Okano HJ, Urasaki Y, Hamada J, Tanaka H, Dang NH, Okano H, Morimoto C.
Nedd9 protein, a Cas-L homologue, is upregulated after transient global ischemia in rats: possible involvement of Nedd9 in the differentiation of neurons after ischemia.
Stroke. 36(11):2457-2462, 2005


Shimizu N, Ouchida R, Yoshikawa N, Hisada T, Watanabe H, Okamoto K, Kusuhara M, Handa H, Morimoto C, Tanaka H.
HEXIM1 forms a transcriptionally abortive complex with glucocorticoid receptor without involving 7SK RNA and positive transcription elongation factor b.
Proc. Natl. Acad. Sci. USA. 102(24):8555-8560, 2005


Hara K, Okamoto M, Aki T, Yagita H, Tanaka H, Mizukami Y, Nakamura H, Tomoda A, Hamasaki N, Kang D.
Synergistic enhancement of TRAIL- and TNFalpha-induced cell death by a phenoxazine derivative.
Mol. Cancer Ther. 4(7):1121-1127, 2005


Ohnuma K, Yamochi T, Uchiyama M, Nishibashi K, Iwata S, Hosono O, Kawasaki H, Tanaka H, Dang NH, Morimoto C.
CD26 mediates dissociation of Tollip and IRAK-1 from caveolin-1 and induces upregulation of CD86 on antigen-presenting cells.
Mol. Cell. Biol. 25:7743-7757, 2005


Sola S, Amaral JD, Castro RE, Ramalho RM, Borralho PM, Kren BT, Tanaka H, Steer CJ, Rodrigues C M.
Nuclear translocation of UDCA by the glucocorticoid receptor is required to reduce TGF-beta1-induced apoptosis in rat hepatocytes.
Hepatology. 42(4):925-934, 2005


Nakamura H, Makino Y, Okamoto K, Poellinger L, Ohnuma K, Morimoto C, Tanaka H.
TCR engagement increases hypoxia-inducible factor-1 protein synthesis via rapamycin-sensitive pathway under hypoxic conditions in human peripheral T cells.
J. Immunol. 174(12):7592-7599, 2005


Urasaki Y, Nori M, Iwata S, Sasaki T, Hosono O, Kawasaki H, Tanaka H, Dang NH, Ikeda E, Morimoto C.
Roxithromycin specifically inhibits development of collagen induced arthritis and production of proinflammatory cytokines by human T cells and macrophages.
J. Rheumatol. 32(9):1765-1774, 2005

2004

Kobayashi H, Hosono O, Iwata S, Kawasaki H, Kuwana M, Tanaka H, Dang NH, Morimoto C.
The tetraspanin CD9 is preferentially expressed on the human CD4(+)CD45RA+ naive T cell population and is involved in T cell activation.
Clin. Exp. Immunol. 137(1):101-108, 2004


Ohnuma K, Yamochi T, Uchiyama M, Nishibashi K, Yoshikawa N, Shimizu N, Iwata S, Tanaka H, Dang NH, Morimoto C.
CD26 up-regulates expression of CD86 on antigen-presenting cells by means of caveolin-1.
Proc. Natl. Acad. Sci. USA. 101(39):14186-14191, 2004

2003

Makino Y, Nakamura H, Ikeda E, Ohnuma K, Yamauchi K, Yabe Y, Poellinger L, Okada Y, Morimoto C, Tanaka H.
Hypoxia-inducible factor regulates survival of antigen receptor-driven T cells.
J. Immunol. 171(12):6534-6540, 2003


Nori M, Iwata S, Munakata Y, Kobayashi H, Kobayashi S, Umezawa Y, Hosono O, Kawasaki H, Dang NH, Tanaka H, Shiohara T, Morimoto C.
Ebastine inhibits T cell migration, production of Th2-type cytokines and proinflammatory cytokines.
Clin. Exp. Allergy. 33(11):1-11, 2003


Matsumoto M, Makino Y, Tanaka T, Tanaka H, Ishizaka N, Noiri E, Fujita T, Nangaku M.
Induction of renoprotective gene expression by cobalt ameliorates ischemic injury of the kidney in rats.
J. Am. Soc. Nephrol. 14(7):1825-1832, 2003


Miyake-Nishijima R, Iwata S, Saijo S, Kobayashi H, Kobayashi S, Souta-Kuribara A, Hosono O, Kawasaki H, Tanaka H, Ikeda E, Okada Y, Iwakura Y, Morimoto C.
Role of Crk-associated substrate lymphocyte type in the pathophysiology of rheumatoid arthritis in tax transgenic mice and in humans.
Arthritis Rheum. 48(7):1890-1900, 2003


Kodama T, Shimizu N, Yoshikawa N, Makino Y, Ouchida R, Okamoto K, Hisada T, Nakamura H, Morimoto C, Tanaka H.
Role of the glucocorticoid receptor for regulation of hypoxia-dependent gene expression.
J. Biol. Chem. 278(35):33384-33391, 2003


Ishii T, Ohnuma K, Murakami A, Takasawa N, Yamochi T, Iwata S, Uchiyama M, Dang NH, Tanaka H, Morimoto C.
SS-A/Ro52, an autoantigen involved in CD28-mediated IL-2 production.
J. Immunol. 170(7):3653-3661, 2003


Ouchida R, Kusuhara M, Shimizu N, Hisada T, Makino Y, Morimoto C, Handa H, Osuzu F, Tanaka H.
Suppression of NF-kappaB-dependent gene expression by a hexamethylene bisacetamide-inducible nuclear protein HEXIM1 in human vascular smooth muscle cells.

2002

Ohnuma K, Ishii T, Iwata S, Hosono O, Kawasaki H, Uchiyama M, Tanaka H, Yamochi T, Dang NH, Morimoto C.
G1/S cell cycle arrest provoked in human T cells by antibody to CD26.
Immunology 107(3):325-333, 2002


Hisakawa N, Tanaka H, Hosono O, Nishijima R, Ohashi Y, Saito S, Nishiya K, Hashimoto K, Morimoto C.
Aberrant responsiveness to RANTES in synovial fluid T cells from patients with rheumatoid arthritis.
J. Rheumatol. 29(6):1124-1134, 2002


Kobayashi H, Hosono O, Mimori T, Kawasaki H, Dang NH, Tanaka H, Morimoto C.
Reduction of serum soluble CD26/dipeptidyl peptidase IV enzyme activity and its correlation with disease activity in systemic lupus erythematosus.
J. Rheumatol. 29(9):1858-1866, 2002


Iwata S, Kobayashi H, Miyake-Nishijima R, Sasaki T, Souta-Kuribara A, Nori M, Hosono O, Kawasaki H, Tanaka H, Morimoto C.
Distinctive signaling pathways through CD82 and beta1 integrins in human T cells.
Eur. J. Immunol. 32(5):1328-1337, 2002


Itoh M, Adachi M, Yasui H, Takekawa T, Tanaka H, Imai K.
Nuclear export of glucocorticoid receptor is enhanced by c-Jun N-terminal kinase-mediated phosphorylation.
Mol. Endocrinol. 16(10):2382-2392, 2002


Makino Y, Kanopka A, Wilson WJ, Tanaka H, Poellinger L.
IPAS is an hypoxia-inducible splicing variant of the HIF-3alpha locus.
J. Biol. Chem. 277(36):32405-32408, 2002


Nishi T, Shimizu N, Hiramoto M, Sato I, Yamaguchi Y, Hasegawa M, Aizawa S, Tanaka H, Kataoka K, Watanabe H, Handa H.
Spatial redox regulation of a critical cysteine residue of NF-kappaB in vivo.
J. Biol. Chem. 277(46):44548-44556, 2002


Kataoka S, Kudo A, Hirano H, Kawakami H, Kawano T, Higashihara E, Tanaka H, Delarue F, Sraer JD, Mune T, Krozowski ZS, Yan K.
11beta-hydroxysteroid dehydrogenase type 2 is expressed in the human kidney glomerulus.
J. Clin. Endocrinol. Metab. 87(2):877-882, 2002


Nakamura T, Ouchida R, Kodama T, Kawashima T, Makino Y, Yoshikawa N, Watanabe S, Morimoto C, Kitamura T, Tanaka H.
Cytokine receptor common subunit-mediated STAT5 activation confers NF-kappaB activation in murine proB Cell Line Ba/F3 Cells.
J. Biol.Chem. 277(8):6254-6265, 2002


Yoshikawa N, Makino Y, Okamoto K, Makino I, Tanaka H.
Distinct interaction of cortivazol with the ligand binding domain confers glucocorticoid receptor specificity.
J. Biol. Chem. 277(7):5529-5540, 2002


Kitano Y, Yokoyama K, Matsumoto K, Makino I, Tanaka H.
Amelioration of cerulein-induced acute pancreatitis by 2, 2’-dipyridyl in rats.
Hokkaido J. Med. Sci. 77(2):161-167, 2002

2001

Miura T, Ouchida R, Yoshikawa N, Makino Y, Nakamura T, Morimoto C, Makino I, Tanaka H.
Functional modulation of the glucocorticoid receptor and repression of NF-kappaB by ursodeoxycholic acid.
J. Biol. Chem. 276(50):47371-47378, 2001


McGuire J, Okamoto K, Whitelaw ML, Tanaka H, Poellinger L.
Definition of a dioxin receptor mutant that is a constitutive activator of transcription: delineation of overlapping repression and ligand binding functions within the PAS domain.
J. Biol. Chem. 276(45):41841-41849, 2001


Makino Y, Cao R, Svensson K, Bertilsson G, Asman M, Tanaka H, Cao Y, Berkenstam A, Poellinger L.
Inhibitory PAS domain protein is a negative regulator of hypoxia-inducible gene expression.
Nature. 414(29):550-554, 2001


Nomura Y, Tanaka H, Poellinger L, Higashino F, Kinjo M.
Monitoring of in vitro translation of green fluorescent protein and its fusion proteins by fluorescence correlation spectroscopy.
Cytometry. 44(1):1-6, 2001


Komura K, Hayashi S, Okamoto K, Makino I, Poellinger L, Tanaka H.
Aryl hydrocarbon receptor/dioxin receptor in U937 cells and human macrophages.
Mol. Cell. Biochem. 226(1-2):107-117, 2001


Homma T, Hosono O, Iwata S, Ando S, Sasaki K, Nishi T, Kawasaki K, Tanaka H, Morimoto C.
Recognition of cell surface GD3 by monoclonal antibody anti-6C2 in rheumatoid arthritis synovial fluid: expression on human T cells with transendothelial migratory activity.
Arthritis Rheum. 4(2):296-306, 2001

2000

Maruyama N, Hirano F, Yoshikawa N, Migita K, Eguchi K, Makino I, Tanaka H.
Thrombin stimulates cell proliferation in human fibroblast-like synoviocytes in NF-kappaB activation and protein kinase C mediated pathway.
J. Rheumatol. 27(12):2777-2785, 2000


Shimizu N, Sugimoto K, Tang J, Nishi T, Sato I, Hiramoto M, Aizawa S, Hatakeyama M, Ohba R, Hatori H, Yoshikawa T, Suzuki F, Oomori A, Tanaka H, Kawaguchi H, Watanabe H, Handa H.
High-performance affinity beads for identifying drug receptors.
Nat. Biotechnol. 18(8):877-881, 2000


Migita K, Tanaka H, Okamoto K, Yoshikawa N, Ichinose Y, Urayama S, Yamasaki S, Ida H, Kawabe Y, Kawakami A, Eguchi K.
FK506 augments glucocorticoid-mediated cyclooxygenase-2 down-regulation in human rheumatoid synovial fibroblasts.
Lab. Invest. 80(2):135-141, 2000


Poukka H, Karvonen U, Yoshikawa N, Tanaka H, Palvimo JJ, Janne OA.
The RING finger protein SNURF modulates nuclear trafficking of the androgen receptor.
J. Cell. Sci. 113(Pt 17):2991-3001, 2000


Iida T, Makino Y, Okamoto K, Yoshikawa N, Makino I, Nakamura T, Tanaka H.
Functional modulation of the mineralocorticoid receptor by cis- diamminedichloroplatinum (II).  
Kidney Int. 58(4):1450-1460, 2000


Ikushima H, Munakata Y, Ishii T, Iwata S, Terashima M, Tanaka H, Schlossman SF, Morimoto C.
Internalization of CD26 by mannose 6-phosphate/insulin-like growth factor II receptor contributes to T cell activation.
Proc. Natl. Acad. Sci. USA. 97(15):8439-8444, 2000


Munakata Y, Iwata S, Dobers J, Ishii T, Nori M, Tanaka H, Morimoto C.
Inhibitory effects on proinflammatory cytokine production and transendothelial migration of T cells.
Arthritis Rheum. 43(7):1616-1623, 2000


Carrero P, Okamoto K, Coumailleau P, O’Brien S, Tanaka H, Poellinger L.
Redox-regulated recruitment of the transcriptional coactivators CREB-Binding protein and SRC-1 to hypoxia-inducible factor 1alpha.
Mol. Cell. Biol. 20(1):402-415, 2000

1999

Yan K, Kudo A, Hirano H, Watanabe T, Tasaka T, Kataoka S, Nakajima N, Nishibori Y, Shibata T, Kohsaka T, Higashihara E, Tanaka H, Watanabe H, Nagasawa T, Awa S.
Subcellular localization of glucocorticoid receptor protein in the human kidney glomerulus.
Kidney Int. 56(1):65-73, 1999


Maekawa K, Yoshikawa N, Du J, Nishikawa S, Kitasato H, Okamoto K, Tanaka H, Mizushima Y, Kawai S.
The molecular mechanism of inhibition of interleukin-1beta-induced cycloxygenase-2 expression in human synovial cells by Tripterygium wilfordii Hook F extract.
Inflamm. Res. 48(11):575-581, 1999


Okamoto K, Tanaka H, Ogawa H, Makino Y, Yoshikawa N, Poellinger L, Umesono K, Makino I.
Redox-dependent regulation of nuclear import of the glucocorticoid receptor.
J. Biol. Chem. 274(15):10363-10371, 1999


Makino Y, Yoshikawa N, Okamoto K, Hirota K, Yodoi J, Makino I, Tanaka H.
Direct association with thioredoxin confers redox regulation of the glucocorticoid receptor function.
J. Biol. Chem. 247(5):3182-3188, 1999

1998

Kallio P, Okamoto K, O’Brien S, Carrero P, Makino Y, Tanaka H, Poellinger L.
Signal transduction in hypoxic cells: inducible nuclear translocation and recruitment of the CBP/p300 coactivator by the hypoxia-inducible factor-1alpha.
EMBO J. 17(22):6573-6586, 1998


Hirano F, Chung M, Tanaka H, Maruyama N, Makino I, Moore D, Scheidereit C.
Alternative splicing variants of IkappaB beta establish differential NF-kappaB signal responsiveness in human cells.
Mol. Cell. Biol. 18(5):2596-2607, 1998


Hirano F, Tanaka H, Hirano Y, Hiramoto M, Handa H, Makino I, Scheidereit C.
Functional interference between Sp1 and NF-kappaB through the same DNA binding site.
Mol. Cell. Biol. 18(3):1266-1274, 1998


Hiramoto M, Shimizu N, Sugimoto K, Tang J, Tanaka H, Makino I, Handa H.
Nuclear-targeted suppression of NF-kappaB activity by the novel quinone derivative E3330.
J. Immunol. 160(12):810-819, 1998


Okamoto K, Tanaka H, Makino Y, Makino I.
Restoration of the glucocorticoid receptor function by the phosphodiester compound of vitamin C and vitamin E, EPC-K1 via a redox-dependent mechanism.
Biochem. Pharmacol. 56(1):79-86, 1998


Hirano F, Tanaka H, Miura T, Hirano Y, Okamoto K, Makino Y, Makino I.
Inhibition of NF-kappaB-dependent transcription of human immunodeficiency virus 1 promoter by a phosphodiester compound of vitamin C and vitamin E, EPC-K1.
Immunopharmacol. 39(1):31-38, 1998

1997

Hayashi S, Hajiro-Nakanishi K, Makino Y, Eguchi H, Yodoi J, Tanaka H.
Functional susceptibility of estrogen receptor by redox change with reference to a role of thioredoxin as a mediator.
Nucleic Acids Res. 25(20):4035-4040, 1997


Tani-Kawakami T, Fukawa E, Tanaka H, Abe Y, Makino I.
Effect of 1alpha-hydroxy vitamin D3 on serum levels of thyroid hormones in patients with untreated Graves’ disease.
Metabolism 46(10):1184-1188, 1997

1996

Makino Y, Okamoto K, Yoshikawa N, Hirota K, Yodoi J, Umesono K, Makino I, Tanaka H.
Thioredoxin: a redox-regulating cellular cofactor for glucocorticoid hormone action.
J. Clin. Invest. 98(11):2469-2477, 1996


Makino Y, Tanaka H, Dahlman-Wright K, Gustafsson JA, Makino I.
Modulation of the glucocorticoid receptor function by metal ions.
Mol. Pharmacol. 49(4):612-620, 1996


Tanaka H, Makino Y, Miura T, Hirano F, Sato Y, Okamoto K, Makino I.
Ligand-independent activation of the glucocorticoid receptor by ursodeoxycholic acid.
J. Immunol. 156(4):1601-1608, 1996


Hirano F, Tanaka H, Makino Y, Okamoto K, Makino I.
Effects of ursodeoxycholic acid and chenodeoxycholic acid on major histocompatibility complex class I gene expression.
J. Gastroenterol. 31(1):55-60, 1996


Hirano F, Tanaka H, Makino Y, Okamoto K, Hiramoto M, Handa H, Makino I.
Induction of the transcription factor AP-1 in cultured colon adenocarcinoma cells following exposure to bile acids.
Carcinogenesis 17(3):427-433, 1996

1995

Tanaka H, Makino Y, Dahlman-Wright K, Gustafsson JA, Okamoto K, Makino I.
Zinc ions antagonize the inhibitory effect of aurothiomalate on glucocorticoid receptor function at physiological concentrations.
Mol. Pharmacol. 48(5):938-945, 1995


Tanaka H, Makino Y, Hiramoto M, Handa H, Makino I.
Potentiation of glucocorticoid-mediated gene expression by the novel benzoquinone derivative (2E)-3-[5-(2, 3-dimethoxy-O-methyl-1, 4-benzoquinoyl)]-2-nonyl-2-propenoic acid (E3330).
Eur. J. Pharmacol. 291(12):121-127, 1995


Hirano F, Tanaka H, Makino Y, Okamoto K, Inaba M, Miura T, Makino I.
Regulation of the major histocompatibility complex class I mRNA expression by bile acids in cultured human hepatoma cells.
Biochem. Biophys. Res. Commun. 208(3):935-942, 1995


Hirano F, Tanaka H, Makino Y, Okamoto K, Inaba M, Nomura Y, Fukawa E, Miura T, Tani T, Makino I.
Natural course of diabetic peripheral neuropathy in spontaneous-onset diabetic Chinese hamsters.
Diabetes Res. Clin. Pract. 28(3):151-159, 1995


Fukawa E, Tanaka H, Makino I.
Identification and characterization of the guanine nucleotide-sensitive melatonin binding sites in the chicken brain.
Neuropharmacol. 34(7):767-776, 1995

1994

Makino Y, Tanaka H, Makino I.
Paradoxycal derepression of the collagenase gene expression by anti-rheumatic gold compound aurothiomalate.
Mol. Pharmacol. 46(6):1084-1089, 1994


Takiyama Y, Tanaka H, Takiyama Y, Makino I.
The effects of hydrocortisone and RU486 (Mifepristone) on iodide-uptake in porcine thyroid cells in primary culture.
Endocrinology 135(5):1972-1979, 1994


Fukawa E, Tanaka H, Hirano F, Kawai S, Akama H, Makino Y, Tani T, Makino I.
Homologous down-regulation of the glucocorticoid receptor down-modulates cellular hormone responsiveness in human histiocytic lymphoma U937 cells.
Endocr. J. 41(6):623-630, 1994


Nagayama S, Yokoi T, Tanaka H, Kawaguchi Y, Shirasaka T, Kamataki T.
Occurrence of autoantibody to protein disulfide isomerase in patients with alcoholic liver disease.
J. Toxicol. Sci. 19(3):163-169, 1994


Tanaka H, Hirano F, Nomura Y, Makino Y, Fukawa E, Makino I.
Relative glucocorticoid potency revisited.
Rheumatol. Int. 14(1):9-12, 1994

1993

Makino Y, Tanaka H, Makino I.
Repression of glucocorticoid receptor function by the anti-rheumatic gold compound aurothiomalate.
Biochem. Biophys. Res. Commun. 197(3):1146-1153, 1993


Hirano F, Tanaka H, Makino I.
Chenodeoxycholic acid-dependent induction of major histocompatibility complex class I antigen expression in a human hepatoma cell line.
Biochem. Biophys. Res. Commun. 195(3):1408-1414, 1993


Tanaka H, Dong Y, McGuire J, Okret S, Poellinger L, Makino I, Gustafsson JA.
The glucocorticoid receptor and a putative repressor protein coordinately modulate glucocorticoid responsiveness of the mouse mammary tumor virus promoter in the rat hepatoma cell line M1. 19.
J. Biol. Chem. 268(3):1854-1859, 1993


Tanaka H, Akama H, Tominaga N, Oshima H, Ichikawa Y, Ikeda Y.
Progressive renal failure in patients with lupus nephritis.
J. Intern. Med. 234(3):257-262, 1993

1992

Tanaka H, Akama H, Ichikawa Y, Makino I, Homma M.
Glucocorticoid receptor and inhibition of 3-O-methyl glucose uptake by glucocorticoids in peripheral blood leukocytes from normal humans.
Acta Endocrinol. 126(1):29-36, 1992


Tanaka H, Makino I.
Ursodeoxycholic acid-dependent activation of the glucocorticoid receptor.
Biochem. Biophys. Res. Commun. 188(2):942-948, 1992


Tanaka H, Akama H, Ichikawa Y, Makino Y, Homma M.
Glucocorticoid receptors in patients with lupus nephritis nephritis – relationship between receptor levels in mononuclear leukocytes and effect of glucocorticoid therapy.
J. Rheumatol. 19(6):878-883, 1992


Tanaka H, Fukawa E, Hirano F, Makino Y, Aoki A, Morikawa Y, Morikawa A, Takiyama Y, Tani T, Makino I.
In vivo monitoring activation by the ligands and specific DNA-binding of the glucocorticoid receptor.
Endocrinol. Jap. 39(5):477-483, 1992

1991

Okret S, Dong Y, Tanaka H, Cairs W, Gustafsson JA.
The mechanism for glucocorticoid resistance in a rat hepatoma cell variant that contains functional glucocorticoid receptor.
J. Steroid Biochem. Mol. Biol. 40(1-3):353-361, 1991


Tanaka H, Akama H, Ichikawa Y, Homma M, Oshima H.
Glucocorticoid receptors in normal human leukocytes: effects of age, gender, seasons, and plasma cortisol concentrations.
Clin. Chem. 37(10 Pt 1):1715-1719, 1991


Tanaka H, Dong Y, Li Q, Okret S, Gustafsson JA.
Identification and characterization of a cis-acting negative element that interferes with glucocorticoid-inducible activation of the mouse mammary tumor virus promoter.
Proc. Natl. Acad. Sci. USA. 88(12):5393-5397, 1991

1989

Tanaka H, Akama H, Ichikawa Y, Homma M.
In vivo responsiveness to glucocorticoid correlated with glucocorticoid receptor contents in peripheral blood leukocytes in normal humans.
Acta Endocrinol. 121(4):470-476, 1989

▶︎ 欧文国際雑誌に掲載した総説
 
Tanaka H, Yoshikawa N, Shimizu N, Morimoto C.
Strategic targeting of the glucocorticoid receptor for anti-inflammation.
Inflamm Regen 27(5):486-493, 2007


Tanaka H, Yoshikawa N, Shimizu N, Morimoto C.
Selective modulation of glucocorticoid receptor function toward development of novel anti-inflammation: lessons from a phenylpyrazolosteroid cortivazol.
Mod Rheumatol. 14:347-355, 2004


Makino Y, Okamoto K, Tanaka H.
Thioredoxin and redox regulation of the nuclear receptor.
Methods Mol Biol. 196:171-181, 2002


Tanaka H, Kanemoto Y.
Molecular Pharmacology of Glucocorticoids: recent advances and future perspectives.
Mod Rheumatol. 11(4):292-299, 2001


Tanaka H, Makino Y, Okamoto K, Iida T, Yoshikawa N, Miura T.
Redox regulation of the nuclear receptor.
Oncology. 59(suppl.1):13-18, 2000


Morimoto C, Kobayashi H, Nishijima R, Tanaka H, Iwata S.
Role of the beta1 integrin molecule in T-cell activation and migration.
Mod Rheumatol. 10(1):8-15, 2000


Tanaka H, Makino Y, Okamoto K, Iida T, Yan K, Yoshikawa N.
Redox regulation of the glucocorticoid receptor.
Antioxid Redox Signal 1(4):403-423, 1999


Makino I, Tanaka H.
From a choleretic to an immunomodulator: historical review of ursodeoxycholic acid as a medicament.
J. Gastroenterol. Hepatol. 13(6):659-664, 1998

▶︎ 欧文著書
 
Hiramoto M, Shimizu N, Nishi T, Shima D, Aizawa S, Tanaka H, Hatakeyama M, Kawaguchi H, Handa H.
High-performance affinity beads for identifying anti-NF-kappaB drug receptors.
Methods Enzymol. 2002;353:81-88.


Makino Y, Okamoto K, Tanaka H.
Thioredoxin and redox regulation of the nuclear receptor.
Oxidants and antioxidants.


Armstrong D, Editor. Humana Press:New Jersey, U.S.A. 2002;171-181.
Tanaka H, Makino Y, Okamoto K, Yoshikawa N, Makino I.
Redox regulation of glucocorticoid hormone action.
Redox Regulation of Cell Signaling and its Clinical Applications.


Yodoi J, Packer L, Editors. Marcel Dekker Inc:New York, U.S.A. 1999;25-47.Tanaka H, Makino Y, Okamoto K. T. hioredoxin in the endocrine response to stress. Vitamins and Hormones. Litwack G, Editor. Academic Press:New York, U.S.A. 1999;153-175


Tanaka H.
Molecular Pharmacology of Glucocorticoids.
Molecular and Genetic Approaches to Diseases.
Niho Y, Editor. Kyushu Univ Press:Japan. 1998;75-84.

▶︎ その他
(欧文国際雑誌に掲載された症例報告、レター)
 
Ohnuma K, Hosono O, Katayose T, Yoshikawa N, Kawasaki H, Fujii T, Oyaizu N, Tanaka H, Morimoto C.
Microscopic polyangiitis initiated with liver dysfunction, calf pain and fever of unknown origin (case report).
Rheumatol Int. 30(12):1651-1656, 2010


Ohnuma K, Hosono O, Kawasaki H, Yoshikawa N, Katayose T, Oyaizu N, Tanaka H, Morimoto C.
An adult case of Henoch-Schonlein purpura complicating common peroneal nerve mononeuropathy (case report).
Mod Rheumatol. 19(1):73-79, 2009


Miura T, Tanaka H, Makino Y, Aoshima M, Makino I.
Human T cell leukemia type I-associated myelopathy in a patient with systemic lupus erythematosus (case report).  
Intern Med. 38(6):512-515, 1999


Aoshima M, Tanaka H, Takahashi M, Nakamura K, Makino I.
Meigs’ syndrome due to Brenner tumor mimicking lupus peritonitis in a patient with systemic lupus erythematosus (case report).
Am J Gastroenterol. 90(4):657-658, 1995


Makino Y, Tanaka H, Nakamura K, Fujita M, Akiyama K, Makino I.
Arthritis in a patient with psoriasis after interferon-alpha therapy for chronic hepatitis C (case report).
J Rheumatol. 21(9):1771-1772, 1994


Akama H, Tanaka H, Yoshida T, Kameda H, Kawai S.
Glucocorticoid-unresponsive fever in a patient with Weber-Christian disease (case report).  
Br. J. Clin. Pract. 48(3):161-162, 1994


Hirano F, Tanaka H, Nomura Y, Matsui T, Makino Y, Fukawa E, Miura T, Makino I.
Successful treatment of refractory polymyositis with pulse intravenous cyclophosphamide and low-dose weekly oral methotrexate therapy (case report).
Intern Med. 32(9):749-752, 1993


Akama H, Tanaka H.
Autoantibodies in pet dogs of Lancetpatients with systemic lupus erythematosus (letter).
Lancet 340(8814):303-304, 1992


Akama H, Tanaka H, Yamada H, Oshima H, Ichikawa Y, Yoshida T, Kawai S, Ikeda Y.
Cushing’s syndrome due to primary adrenocortical nodular dysplasia, cardiac myxomas, and spotty pigmentation, complicated by sarcoidosis (case report).
Intern Med. 31(11):1329-1334, 1992