Department of Rheumatology
and Allergy.
Last Updated 2017.11.20

 

 
 
 
 
 
 

2017

Naoki Ito, Isao Kii, Noriaki Shimizu, Hirotoshi Tanaka and Shin’ichi Takeda
Direct reprogramming of fibroblasts into skeletal muscle progenitor cells by transcription factors enriched in undifferentiated subpopulation of satellite cells
Sci Rep. In Press


Hirotoshi Tanaka, Noriaki Shimizu, Noritada Yoshikawa
Role of skeletal muscle glucocorticoid receptor in systemic energy homeostasis
Exp Cell Res. 2017 Mar 24. pii: S0014-4827(17)30176-3. doi: 10.1016


Toshiki Eri, Kimito Kawahata, Takeyuki Kanzaki, Mitsuru Imamura, Kazuya Michishita, Lisa Akahira, Ei Bannai, Noritada Yoshikawa, Yasumasa Kimura, Takeshi Satoh, Satoshi Uematsu, Hirotoshi Tanaka, and Kazuhiko Yamamoto
Intestinal microbiota link lymphopenia to murine autoimmunity via PD-1+CXCR5-/dim B-helper T cell induction.
Sci Rep. 2017;7:46037.doi: 10.1038/srep46037


Ono T, Kamimura N, Matsuhashi T, Nagai T, Nishiyama T, Endo J, Hishiki T, Nakanishi T, Shimizu N, Tanaka H, Ohta S, Suematsu M, Ieda M, Sano M, Fukuda K, Kaneda R.
The histone 3 lysine 9 methyltransferase inhibitor chaetocin improves prognosis in a rat model of high salt diet-induced heart failure.
Sci Rep. 2017 Jan 4;7:39752. doi: 10.1038/srep39752.


Erika Matsubara, Noritada Yoshikawa, Osamu Hosono, Hiroyuki Baba, Toshiki Eri, Masaaki Uehara, Aya Oda, Chieko Sekita, Atsuo Taniguchi, Hirotoshi Tanaka
A rheumatoid arthritis patient complicated with adenine phosphoribosyltransferase deficiency and unilateral renal agenesis: a first case report
Modern Rheumatology Case Reports, 1:1, 15-19, 2017


Yoshikawa N, Shimizu N, Uehara M, Oda Y, Matsumiya R, Matsubara E, Kobayashi H, Hosono O, Kuribara-Souta A, Baba H, Nagamura F, Kiryu S, Tanaka H.
The effects of bolus supplementation of branched-chain amino acids on skeletal muscle mass, strength, and function in patients with rheumatic disorders during glucocorticoid treatment.
Mod Rheumatol. 2017 May;27(3):508-517. doi: 10.1080/14397595.2016.1213480. Epub 2016 Sep 28.

2016

Ito N, Shimizu N, Tanaka H, Takeda S.
Enhancement of Satellite Cell Transplantation Efficiency by Leukemia Inhibitory Factor.
J Neuromuscul Dis. 3:201-207, 2016. 


Kobayashi H, Uehara M, Oda A, Matsubara E, Baba H, Matsumiya R, Yoshikawa N, Hosono O, Tanaka H. 
Normal pressure hydrocephalus, a possible complication in IgG4-related disease.
Interdisciplinary Neurosurgery. 5:1-2, 2016.


Ishii H, Konuma T, Ohnuma K, Hosono O, Tanaka H, Kato S, Tojo A, Takahashi S.
Remission of remitting seronegative symmetrical synovitis with pitting edema after unrelated cord blood transplantation for myelodysplastic syndrome.
Ann Hematol. 2016 Feb;95(3):523-4. doi: 10.1007/s00277-015-2555-0. No abstract available.

2015

Matsumiya R, Hosono O, Yoshikawa N, Uehara M, Kobayashi H, Oda A, Matsubara E, Tanada S, Shintani Y, Nagayama K, Nakajima J, Tanaka H.
Elevated Serum IgG4 Complicated by Pericardial Involvement with a Patchy (18)F-FDG Uptake in PET/CT: Atypical Presentation of IgG4-related Disease.
Intern Med. 54:2337-41, 2015.


Shimizu N, Maruyama T, Yoshikawa N, Matsumiya R, Ma Y, Ito N, Tasaka Y, Kuribara-Souta A, Miyata K, Oike Y, Berger S, Schutz G, Takeda S, Tanaka H.
A muscle-liver-fat signalling axis is essential for central control of adaptive adipose remodelling.
Nat Commun. 6:6693, 2015. 
日本語での解説 医科学研究所ホームページ


Katayose T, Iwata S, Oyaizu N, Hosono O, Yamada T, Dang NH, Hatano R, Tanaka H, Ohnuma K, Morimoto C.
The role of Cas-L/NEDD9 as a regulator of collagen-induced arthritis in a murine model.
Biochem Biophys Res Commun. 460:1069-75, 2015.


Hosono O, Yoshikawa N, Shimizu N, Kiryu S, Uehara M, Kobayashi H, Matsumiya R, Kuribara A, Maruyama T, Tanaka H.
Quantitative analysis of skeletal muscle mass in patients with rheumatic diseases under glucocorticoid therapy--comparison among bioelectrical impedance analysis, computed tomography, and magnetic resonance imaging.
Mod Rheumatol. 25:257-63, 2015.


Otsuki N, Iwata S, Yamada T, Hosono O, Dang NH, Hatano R, Ohnuma K, & Morimoto C.
Modulation of immunological responses and amelioration of collagen-induced arthritis by the novel roxithromycin derivative 5-I.
Mod Rheumatol. 25:562-70, 2015.


Ohnuma K, Saito T, Hatano R, Hosono O, Iwata S, Dang NH, Ninomiya H, & Morimoto C.
Comparison of two commercial ELISAs against an in-house ELISA for measuring soluble CD26 in human serum.
J Clin Lab Anal. 29:106-11, 2015. 

2014

Yoshikawa N, Shimizu N, Ojima H, Kobayashi H, Hosono O, Tanaka H.
Down-regulation of hypoxia-inducible factor-1 alpha and vascular endothelial growth factor by HEXIM1 attenuates myocardial angiogenesis in hypoxic mice.Biochem Biophys Res Commun. 53:600-605, 2014.


Miyake Y, Tanaka K, Nishikawa T, Naruse M, Takayanagi R, Sasano H, Takeda Y, Shibata H, Sone M, Satoh F, Yamada M, Ueshiba H, Katabami T, Iwasaki Y, Tanaka H, Tanahashi Y, Suzuki S, Hasegawa T, Katsumata N, Tajima T, Yanase T. Prognosis of primary aldosteronism in Japan: results from a nationwide epidemiological study. Endocr J. 61(1):35-40, 2014.


Fujimoto N, Ohnuma K, Aoe K, Hosono O, Yamada T, Kishimoto T, Morimoto C.
Clinical significance of soluble CD26 in malignant pleural mesothelioma. 
PLoS One. 9:e115647, 2014.

2012

Yoshikawa N, Shimizu N, Maruyama T, Sano M, Matsuhashi T, Fukuda K, Kataoka M, Satoh T, Ojima H, Sawai T, Morimoto C, Kuribara A, Hosono O, Tanaka H.
Cardiomyocyte-specific overexpression of HEXIM1 prevents right ventricular hypertrophy in hypoxia-induced pulmonary hypertension in mice.
PLoS One. 7:e52522, 2012.


Kondo S, Iwata S, Yamada T, Inoue Y, Ichihara H, Kichikawa Y, Katayose T, Souta-Kuribara A, Yamazaki H, Hosono O, Kawasaki H, Tanaka H, Hayashi Y, Sakamoto M, Kamiya K, Dang NH, Morimoto C.
Impact of the integrin signaling adaptor protein NEDD9 on prognosis and metastatic behavior of human lung cancer.Clin.
Cancer Res. 18:6326-38, 2012.


Aoe K, Amatya VJ, Fujimoto N, Ohnuma K, Hosono O, Hiraki A, Fujii M, Yamada T, Dang NH, Takeshima Y, Inai K, Kishimoto T, Morimoto C.
CD26 overexpression is associated with prolonged survival and enhanced chemosensitivity in malignant pleural mesothelioma.
Clin Cancer Res. 18:1447-1456, 2012.

2011

Toyokawa G, Cho HS, Iwai Y, Yoshimatsu M, Takawa M, Hayami S, Maejima K, Shimizu N, Tanaka H, Tsunoda T, Field HI, Kelly JD, Neal DE, Ponder BA, Maehara Y, Nakamura Y, Hamamoto R.
The histone demethylase JMJD2B plays an essential role in human carcinogenesis through positive regulation of cyclin-dependent kinase 6.
Cancer Prev Res (Phila). 4:2051-61, 2011.


Shimizu N, Yoshikawa N, Ito N, Maruyama T, Suzuki Y, Takeda S, Nakae J, Tagata Y, Nishitani S, Takehana K, Sano M, Fukuda K, Suematsu M, Morimoto C, Tanaka H.
Crosstalk between glucocorticoid receptor and nutritional sensor mTOR in skeletal muscle.
Cell Metab. 13:170-182, 2011.
日本語での解説 医科学研究所ホームーページ , ライフサイエンス新着論文レビュー


Mu SY, Shimosawa T, Ogura S, Wang H, Uetake Y, Kawakami-Mori F, Marumo T, Yatomi Y, Geller DS, Tanaka H, Fujita T.
Epigenetic modulation of the renal β-adrenergic–WNK4 pathway in salt-sensitive hypertension.
Nat. Med. 17 (5):573 – 580, 2011

2010

Fukazawa T, Maeda Y, Matsuoka J, Ono T, Mominoki K, Yamatsuji T, Shigemitsu K, Morita I, Murakami I, Tanaka H, Durbin ML, Naomoto Y.
Targeting KRAS mutation-bearing lung cancer in vivo by pulmonary surfactant-adenovirus-mediated gene transfer.
Anticancer Res. 30(12):4925-4935, 2010


Ohnuma K, Hosono O, Katayose T, Yoshikawa N, Kawasaki H, Fujii T, Oyaizu N, Tanaka H, Morimoto C.
Microscopic polyangiitis initiated with liver dysfunction, calf pain and fever of unknown origin.
Rheumatol Int. 30:1651-1656, 2010

2009

Ohnuma K, Hosono O, Kawasaki H, Yoshikawa N, Katayose T, Oyaizu N, Tanaka H, Morimoto C.
An adult case of Henoch-Schönlein purpura complicating common peroneal nerve mononeuropathy.
Mod Rheumatol. 19:73-9, 2009.


Ohnuma K, Uchiyama M, Hatano R, Takasawa W, Endo Y, Dang NH, Morimoto C.
Blockade of CD26-mediated T cell costimulation with soluble caveolin-1-Ig fusion protein induces anergy in CD4+T cells.
Biochem Biophys Res Commun. 386:327-32, 2009.


Yoshikawa N, Nagasaki M, Sano M, Tokudome S, Ueno K, Shimizu N, Imoto S, Miyano S, Suematsu M, Fukuda K, Morimoto C, Tanaka H.
Ligand-based gene expression profiling reveals novel roles of glucocorticoid receptor in cardiac metabolism.
Am J Physiol Endocrinol Metab. 296:E1363-1373, 2009.


Tokudome S, Sano M, Shinmura K, Matsuhashi T, Morizane S, Moriyama H, Tamaki K, Hayashida K, Nakanishi H, Yoshikawa N, Shimizu N, Endo J, Katayama T, Murata M, Yuasa S, Kaneda R, Tomita K, Eguchi N, Urade Y, Asano K, Utsunomiya Y, Suzuki T, Taguchi R, Tanaka H, Fukuda K.
Glucocorticoid protects rodent hearts from ischemia/reperfusion injury by activating lipocalin-type prostaglandin D synthase-derived PGD2 biosynthesis.
J Clin Invest. 119:1477-88, 2009.


Yo K, Iwata S, Hashizume Y, Kondo S, Nomura S, Hosono O, Kawasaki H, Tanaka H, Dang NH, Morimoto C.
SHP-2 inhibits tyrosine phosphorylation of Cas-L and regulates cell migration.
Biochem Biophys Res Commun. 382:210-4, 2009.


Fukazawa T, Maeda Y, Matsuoka J, Naomoto Y, Tanaka H, Durbin ML, Tanaka N.
Drug-regulatable cancer cell death induced by BID under control of the tissue-specific, lung cancer targeted TTS promoter system.
Int. J. Cancer 125(8):1975-1984, 2009

2008

Hozawa S, Nakamura T, Nakano M, Adachi M, Tanaka H, Takahashi Y, Tetsuya M, Miyata N, Soma H, Hibi T.
Induction of matrix metalloproteinase-1 gene transcription by tumour necrosis factor alpha via the p50/p50 homodimer of nuclear factor-kappa B inactivated human hepatic stellate cells.
Liver Int. 28(10):1418-1425, 2008


Shibata S, Nagase M, Yoshida S, Kawarazaki W, Kurihara H, Tanaka H, Miyoshi J, Takai Y, Fujita T.
Modification of mineralocorticoid receptor function by Rac1 GTPase: implication in proteinuric kidney disease.
Nat. Med. 14(12):1370-1376, 2008


Yoshikawa N, Shimizu N, Sano M, Ohnuma K, Iwata S, Hosono O, Fukuda K, Morimoto C, Tanaka H.
Role of the hinge region of glucocorticoid receptor for HEXIM1-mediated transcriptional repression.
Biochem Biophys Res Commun. 20;371:44-49, 2008.


Shimizu N, Yoshikawa N, Wada T, Handa H, Sano M, Fukuda K, Suematsu M, Sawai T, Morimoto C, Tanaka H.
Tissue- and context-dependent modulation of hormonal sensitivity of glucocorticoid-responsive genes by hexamethylene bisacetamide-inducible protein 1.
Mol Endocrinol. 22:2609-2623, 2008.


Ohnuma K, Dang NH, Morimoto C.
Revisiting an old acquaintance: CD26 and its molecular mechanisms in T cell function.
[Review article]
Trends Immunol. 29:295-301, 2008.


Yamochi T, Ohnuma K, Hosono O, Tanaka H, Kanai Y, Morimoto C.
SSA/Ro52 autoantigen interacts with Dcp2 to enhance its decapping activity.
Biochem Biophys Res Commun. 370:195-199, 2008.


Ohnuma K, Takahashi N, Yamochi T, Hosono O, Dang NH, Morimoto C.
Role of CD26/dipeptidyl peptidase IV in human T cell activation and function.
Front Biosci. 13:2299-2310, 2008. [Review article]


Kagawa T, Watanabe N, Mochizuki K, Numari A, Ikeno Y, Itoh J, Tanaka H, Arias IM, Mine T.
Phenotypic differences in PFIC2 and BRIC2 correlate with protein stability of mutant Bsep and impaired taurocholate secretion in MDCK II cells.
Am. J. Physiol. Gastrointest.Liver Physiol. 294(1):G58-67, 2008


Yamashita T, Ohneda O, Nagano M, Iemitsu M, Makino Y, Tanaka H, Miyauchi T, Goto K, Ohneda K, Fujii-Kuriyama Y, Poellinger L, Yamamoto M.
Abnormal heart development and lung remodeling in mice lacking the hypoxia-inducible factor-related basic helix-loop-helix PAS protein NEPAS.
Mol. Cell. Biol. 28(4):1285-1297, 2008

2007

Sano M, Tokudome S, Shimizu N, Yoshikawa N, Ogawa C, Shirakawa K, Endo J, Katayama T, Yuasa S, Ieda M, Makino S, Hattori F, Tanaka H, Fukuda K.
Intramolecular control of protein stability, subnuclear compartmentalization, and coactivator function of peroxisome proliferator-activated receptor gamma coactivator 1alpha.
J Biol Chem. 282:25970-80, 2007.


Inamoto T, Yamada T, Ohnuma K, Kina S, Takahashi N, Yamochi T, Inamoto S, Katsuoka Y, Hosono O, Tanaka H, Dang NH, Morimoto C.
Humanized anti-CD26 monoclonal antibody as a treatment for malignant mesothelioma tumors.
Clin Cancer Res. 13:4191-200, 2007.


Makino Y, Uenishi R, Okamoto K, Isoe T, Hosono O, Tanaka H, Kanopka A, Poellinger L, Haneda M, Morimoto C.
Transcriptional up-regulation of inhibitory PAS domain protein gene expression by hypoxia-inducible factor 1 (HIF-1): a negative feedback regulatory circuit in HIF-1-mediated signaling in hypoxic cells.
J Biol Chem. 282:14073-82, 2007.


Ohnuma K, Uchiyama M, Yamochi T, Nishibashi K, Hosono O, Takahashi N, Kina S, Tanaka H, Lin X, Dang NH, Morimoto C.
Caveolin-1 triggers T-cell activation via CD26 in association with CARMA1.
J Biol Chem. 282:10117-31, 2007.


Inamoto S, Iwata S, Inamoto T, Nomura S, Sasaki T, Urasaki Y, Hosono O, Kawasaki H, Tanaka H, Dang NH, Morimoto C.
Crk-associated substrate lymphocyte type regulates transforming growth factor-beta signaling by inhibiting Smad6 and Smad7.
Oncogene. 26:893-904, 2007.


Fukazawa T, Maeda Y, Durbin ML, Nakai T, Matsuoka J, Tanaka H, Naomoto Y, Tanaka N.
Pulmonary adenocarcinoma-targeted gene therapy by a cancer- and tissue-specific promoter system.
Mol. Cancer. Ther. 6(1):244-252, 2007


Sano M, Izumi Y, Helenius K, Asakura M, Rossi DJ, Xie M, Taffet G, Hu L, Pautler RG, Wilson CR, Boudina S, Abel ED, Taegtmeyer H, Scaglia F, Graham BH, Kralli A, Shimizu N, Tanaka H, Mäkelä TP, Schneider MD.
Ménage-à-trois 1 is critical for the transcriptional function of PPARgamma coactivator 1.
Cell Metab. 5:129-42, 2007.

2006

Ohnuma K, Inoue H, Uchiyama M, Yamochi T, Hosono O, Dang NH, Morimoto C.
T-cell activation via CD26 and caveolin-1 in rheumatoid synovium. [Review article]
Mod Rheumatol. 16:3-13, 2006.

2005

Sasaki T, Iwata S, Okano HJ, Urasaki Y, Hamada J, Tanaka H, Dang NH, Okano H, Morimoto C.
Nedd9 protein, a Cas-L homologue, is upregulated after transient global ischemia in rats: possible involvement of Nedd9 in the differentiation of neurons after ischemia.
Stroke. 36:2457-62, 2005.


Ohnuma K, Yamochi T, Uchiyama M, Nishibashi K, Iwata S, Hosono O, Kawasaki H, Tanaka H, Dang NH, Morimoto C.
CD26 mediates dissociation of Tollip and IRAK-1 from caveolin-1 and induces upregulation of CD86 on antigen-presenting cells.
Mol Cell Biol. 25:7743-57, 2005.


Nakamura H, Makino Y, Okamoto K, Poellinger L, Ohnuma K, Morimoto C, Tanaka H.
TCR engagement increases hypoxia-inducible factor-1 alpha protein synthesis via rapamycin-sensitive pathway under hypoxic conditions in human peripheral T cells.
J Immunol. 174:7592-9, 2005.


Shimizu N, Ouchida R, Yoshikawa N, Hisada T, Watanabe H, Okamoto K, Kusuhara M, Handa H, Morimoto C, Tanaka H.
HEXIM1 forms a transcriptionally abortive complex with glucocorticoid receptor without involving 7SK RNA and positive transcription elongation factor b.
Proc Natl Acad Sci U S A. 102:8555-60, 2005.


Hara K, Okamoto M, Aki T, Yagita H, Tanaka H, Mizukami Y, Nakamura H, Tomoda A, Hamasaki N, Kang D.
Synergistic enhancement of TRAIL- and tumor necrosis factor α–induced cell death by a phenoxazine derivative.
Mol. Cancer Ther. 4(7):1121-1127, 2005


Manotham K, Tanaka T, Ohse T, Kojima I, Miyata T, Inagi R, Tanaka H, Sassa R, Fujita T, Nangaku M.
A biologic role of HIF-1 in the renal medulla.
Kidney Int. 67(4):1428-1439, 2005


Yoshikawa N, Yamamoto K, Shimizu N, Yamada S, Morimoto C, Tanaka H.
The distinct agonistic properties of the phenylpyrazolosteroid cortivazol reveal interdomain communication within the glucocorticoid receptor.
Mol Endocrinol. 19:1110-24, 2005.


Iwata S, Souta-Kuribara A, Yamakawa A, Sasaki T, Shimizu T, Hosono O, Kawasaki H, Tanaka H, Dang NH, Watanabe T, Arima N, Morimoto C.
HTLV-I Tax induces and associates with Crk-associated substrate lymphocyte type (Cas-L).
Oncogene. 24:1262-71, 2005.


Urasaki Y, Nori M, Iwata S, Sasaki T, Hosono O, Kawasaki H, Tanaka H, Dang NH, Ikeda E, Morimoto C.
Roxithromycin specifically inhibits development of collagen induced arthritis and production of proinflammatory cytokines by human T cells and macrophages.
J Rheumatol. 32:1765-1774, 2005.


Ohnuma K, Yamochi T, Hosono O, Morimoto C.
CD26 T cells in the pathogenesis of asthma.
Clin Exp Immunol. 139:13-16, 2005. [Review article]


Sola S, Amaral JD, Castro RE, Ramalho RM, Borralho PM, Kren BT, Tanaka H, Steer CJ, Rodrigues C M.
Nuclear translocation of UDCA by the glucocorticoid receptor is required to reduce TGF-beta1-induced apoptosis in rat hepatocytes.
Hepatology. 42(4):925-934, 2005

2004

Ohnuma K, Yamochi T, Uchiyama M, Nishibashi K, Yoshikawa N, Shimizu N, Iwata S, Tanaka H, Dang NH, Morimoto C.
CD26 up-regulates expression of CD86 on antigen-presenting cells by means of caveolin-1.
Proc Natl Acad Sci U S A. 101:14186-91, 2004.


Kobayashi H, Hosono O, Iwata S, Kawasaki H, Kuwana M, Tanaka H, Dang NH,Morimoto C.
The tetraspanin CD9 is preferentially expressed on the human CD4(+)CD45RA+ naive T cell population and is involved in T cell activation.
Clin Exp Immunol. 137:101-8, 2004.


Tanaka H, Yoshikawa N, Shimizu N, Morimoto C.
Selective modulation of glucocorticoid receptor function toward development of novel anti-inflammation: lessons from a phenyl-pyrazolo-steroid cortivazol. [Review article]
Mod Rheumatol. 14:347-55, 2004.

2003

Makino Y, Nakamura H, Ikeda E, Ohnuma K, Yamauchi K, Yabe Y, Poellinger L, Okada Y, Morimoto C, Tanaka H.
Hypoxia-inducible factor regulates survival of antigen receptor-driven T cells.
J Immunol. 171:6534-40, 2003.


Nori M, Iwata S, Munakata Y, Kobayashi H, Kobayashi S, Umezawa Y, Hosono O, Kawasaki H, Dang NH, Tanaka H, Shiohara T, Morimoto C.
Ebastine inhibits T cell migration, production of Th2-type cytokines and proinflammatory cytokines.
Clin Exp Allergy. 33:1544-54, 2003.


Matsumoto M, Makino Y, Tanaka T, Tanaka H, Ishizaka N, Noiri E, Fujita T, Nangaku M.
Induction of renoprotective gene expression by cobalt ameliorates ischemic injury of the kidney in rats.
J. Am. Soc. Nephrol. 14(7):1825-1832, 2003


Kodama T, Shimizu N, Yoshikawa N, Makino Y, Ouchida R, Okamoto K, Hisada T, Nakamura H, Morimoto C, Tanaka H.
Role of the glucocorticoid receptor for regulation of hypoxia-dependent gene expression.
J Biol Chem. 278:33384-91, 2003.


Ishii T, Ohnuma K, Murakami A, Takasawa N, Yamochi T, Iwata S, Uchiyama M, Dang NH, Tanaka H, Morimoto C.
SS-A/Ro52, an autoantigen involved in CD28-mediated IL-2 production.
J Immunol. 170:3653-61, 2003.


Ouchida R, Kusuhara M, Shimizu N, Hisada T, Makino Y, Morimoto C, Handa H, Ohsuzu F, Tanaka H.
Suppression of NF-kappaB-dependent gene expression by a hexamethylene bisacetamide-inducible protein HEXIM1 in human vascular smooth muscle cells.
Genes Cells. 8:95-107, 2003.


Miyake-Nishijima R, Iwata S, Saijo S, Kobayashi H, Kobayashi S, Souta-Kuribara A, Hosono O, Kawasaki H, Tanaka H, Ikeda E, Okada Y, Iwakura Y, Morimoto C.
Role of Crk-associated substrate lymphocyte type in the pathophysiology of rheumatoid arthritis in tax transgenic mice and in humans.
Arthritis Rheum. 48:1890-1900, 2003.


Hosono O, Ohnuma K, Dang NH, & Morimoto C.
CD26: a key molecule in immune regulation and autoimmune diseases.
Mod Rheumatol. 13:199-204, 2003. [Review article]

2002

Ohnuma K, Ishii T, Iwata S, Hosono O, Kawasaki H, Uchiyama M, Tanaka H, Yamochi T, Dang NH, Morimoto C.
G1/S cell cycle arrest provoked in human T cells by antibody to CD26.
Immunology. 107:325-33, 2002.


Kobayashi H, Hosono O, Mimori T, Kawasaki H, Dang NH, Tanaka H, Morimoto C.
Reduction of serum soluble CD26/dipeptidyl peptidase IV enzyme activity and its correlation with disease activity in systemic lupus erythematosus.
J Rheumatol. 29:1858-66, 2002.


Hisakawa N, Tanaka H, Hosono O, Nishijima R, Ohashi Y, Saito S, Nishiya K, Hashimoto K, Morimoto C.
Aberrant responsiveness to RANTES in synovial fluid T cells from patients with rheumatoid arthritis.
J Rheumatol. 29:1124-34, 2002.


Nakamura T, Ouchida R, Kodama T, Kawashima T, Makino Y, Yoshikawa N, Watanabe S, Morimoto C, Kitamura T, Tanaka H.
Cytokine receptor common beta subunit-mediated STAT5 activation confers NF-kappa B activation in murine proB cell line Ba/F3 cells.
J Biol Chem. 277:6254-65, 2002.


Yoshikawa N, Makino Y, Okamoto K, Morimoto C, Makino I, Tanaka H.
Distinct interaction of cortivazol with the ligand binding domain confers glucocorticoid receptor specificity: cortivazol is a specific ligand for the glucocorticoid receptor.
J Biol Chem. 277:5529-40, 2002.


Iwata S, Kobayashi H, Miyake-Nishijima R, Sasaki T, Souta-Kuribara A, Nori M, Hosono O, Kawasaki H, Tanaka H, Morimoto C.
Distinctive signaling pathways through CD82 and beta1 integrins in human T cells.
Eur J Immunol. 32:1328-1337, 2002.


Itoh M, Adachi M, Yasui H, Takekawa T, Tanaka H, Imai K.
Nuclear Export of Glucocorticoid Receptor is Enhanced by c-Jun N-Terminal Kinase-Mediated Phosphorylation.
Mol. Endocrinol. 16(10):2382-2392, 2002


Makino Y, Kanopka A, Wilson WJ, Tanaka H, Poellinger L.
Inhibitory PAS Domain Protein (IPAS) Is a Hypoxia-inducible Splicing Variant of the Hypoxia-inducible Factor-3α Locus.
J. Biol. Chem. 277(36):32405-32408, 2002


Nishi T, Shimizu N, Hiramoto M, Sato I, Yamaguchi Y, Hasegawa M, Aizawa S, Tanaka H, Kataoka K, Watanabe H, Handa H.
Spatial Redox Regulation of a Critical Cysteine Residue of NF-κB in Vivo.
J. Biol. Chem. 277(46):44548-44556, 2002


Kataoka S, Kudo A, Hirano H, Kawakami H, Kawano T, Higashihara E, Tanaka H, Delarue F, Sraer JD, Mune T, Krozowski ZS, Yan K.
11beta-hydroxysteroid dehydrogenase type 2 is expressed in the human kidney glomerulus.
J. Clin. Endocrinol. Metab. 87(2):877-882, 2002


Kitano Y, Yokoyama K, Matsumoto K, Makino I, Tanaka H.
Amelioration of cerulein-induced acute pancreatitis by 2, 2’-dipyridyl in rats.
Hokkaido J. Med. Sci. 77(2):161-167, 2002

2001

Miura T, Ouchida R, Yoshikawa N, Okamoto K, Makino Y, Nakamura T, Morimoto C, Makino I, Tanaka H.
Functional modulation of the glucocorticoid receptor and suppression of NF-kappaB-dependent transcription by ursodeoxycholic acid.
J Biol Chem. 276:47371-8, 2001.


McGuire J, Okamoto K, Whitelaw ML, Tanaka H, Poellinger L.
Definition of a dioxin receptor mutant that is a constitutive activator of transcription: delineation of overlapping repression and ligand binding functions within the PAS domain.
J. Biol. Chem. 276(45):41841-41849, 2001


Makino Y, Cao R, Svensson K, Bertilsson G, Asman M, Tanaka H, Cao Y, Berkenstam A, Poellinger L.
Inhibitory PAS domain protein is a negative regulator of hypoxia-inducible gene expression.
Nature. 414(29):550-554, 2001


Nomura Y, Tanaka H, Poellinger L, Higashino F, Kinjo M.
Monitoring of in vitro translation of green fluorescent protein and its fusion proteins by fluorescence correlation spectroscopy.
Cytometry. 44(1):1-6, 2001


Komura K, Hayashi S, Okamoto K, Makino I, Poellinger L, Tanaka H.
Aryl hydrocarbon receptor/dioxin receptor in U937 cells and human macrophages.
Mol. Cell. Biochem. 226(1-2):107-117, 2001


Homma T, Hosono O, Iwata S, Ando S, Sasaki K, Nishi T, Kawasaki H, Tanaka H, Morimoto C.
Recognition of cell surface GD3 by monoclonal antibody anti-6C2 in rheumatoid arthritis synovial fluid: expression on human T cells with transendothelial migratory activity.
Arthritis Rheum. 44:296-306, 2001.


Ohnuma K, Munakata Y, Ishii T, Iwata S, Kobayashi S, Hosono O, Kawasaki H, Dang NH, Morimoto C.
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