●Publication of 2005-2010
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	1. Kobayashi, R., Kohda, T., Kataoka, K., Ihara, H., Kozaki, S., Pascual, DW., Staats, HF., Kiyono, H., McGhee, JR., and Fujihashi, K. 2005. A novel neurotoxoid vaccine prevents mucosal botulism. J. Immunol. 174: 2190-2195 2. Nonaka, S., Naito, T., Chen, H., Yamamoto, M., Moro, K., Kiyono, H., Hamada, H. and Ishikawa, H. 2005. Intestinal γδ T cells develop in mice lacking thymus, all lymph nodes, Peyer's patches, and isolated lymphoid follicles. J. Immunol. 174: 1906-1912 3. Kweon, MN., Yamamoto, M., Rennert, P.D., Park, EJ., Lee, AY., Chang, SN., Hiroi, T., Nanno, M. and Kiyono, H. 2005 Prenatal blockage of LTbR and TNFRp55 signaling cascade resulted in the acceleration of tissue genesis for isolated lymphoid follicles in the large intestine. J. Immunol. 174: 4365-4372. 4. Ueta, M., Hamuro, J., Kiyono, H. and Kinoshita, S. 2005. Triggering of TLR3 by poly:C in human corneal epithelial cells to induce inflammatory cytokines. Biochem. Biophy. Res. Commun. 331: 285-294. 5. Kai, Y., Takahashi, I., Ishikawa, H., Hiroi, T., Mizushima, T., Matsuda, C., Kishi, D., Hamada, H., Tamagawa, H., Ito, T., Yoshizaki, K., Kishimoto, T., Matsuda, H., and Kiyono, H. 2005. Colitis in mice lacking hte common cytokine receptor γ chain is mediated by IL-6-producing CD4+ T cells. Gastroenterology 128: 922-934. 6. Hino, A., Fukuyama, S., Kataoka, K., Kweon, M., Kataoka, K., and Kiyono, H. 2005 Nasal IL-12p70 prevents and treats intestinal allergic diarrhea. J. Immunol. 174: 7423-7432. 7. Ohmura, M., Yamamoto, M., Tomiyama-Miyaji, C., Yuki, Y., Takeda, Y. and Kiyono, H. 2005. Nontoxic Stx derivatives from Escherichia coli possess adjivant activity for augmentation of antigen-specific immune responses via DC activation. Infect. Immunol. 73: 4088-4097. 8. Kunisawa, J., and Kiyono, H. 2005. A marvel of mucosal T cells and secretory antibodies for the creation of first lines of defense. Cell. Mol. Life. Sci. 62: 1308-1321. 9. Ishikawa, H., Kanamori, Y., Hamada, H.,, and Kiyono, H. 2005 Book chapter: Development and function of organized gut-associated lymphoid tissues.. In: Mestecky,J., Lamm, M. E., Strober, W., Bienenstock, J., McGhee, J. R., and Mayer, L.. editors. Mucosal Immunology 3rd Ed. Amsterdam, ELSEVIER; 385-406. 10. Kweon, M. N. and Kiyono, H. 2005 Book chapter: Allergic diseases in the gastrointestinal tract. Mucosa-associated lymphoid tissues in the aerodigestive tract. In: Mestecky,J., Lamm, M. E., Strober, W., Bienenstock, J., McGhee, J. R., and Mayer, L.. editors. Mucosal Immunology 3rd Ed. Amsterdam, ELSEVIER; 1351-1360. 11. Yuki, Y., Hara-Yokoyama, C., Guadiz, A.A., Udaka, S., Kiyono, H., and Chatterjee, S. 2005 Production of a recombinant cholera toxin B subunit-insulin B chain peptide hybrid protein by Brevibacillus choshinensis expression system as a nasal vaccine against autoimmune diabetes.. Biotechnol. Bioeng. Sep 2 (Epub ahead of print) 12. Kunisawa, J., Fukuyama, S., and Kiyono, H. 2005 Mucosa-associated lymphoid tissues in the aerodigestive tract: Their shared and divergent traits and their importance to the orchestration of the mucosal immune system.. Curr. Mol. Med. 5: 557-572. 13. Takagi, H., Hiroi, T., Yang, L., Tada, Y., Yuki, Y., Takamura, K., Ishimitsu, R., Kawauchi, H., Kiyono, H., and Takaiwa, F.. 2005 A rice-based edible vaccine expressing multiple T cell epitopes induces oral tolerance for inhibition of Th2-mediated IgE responses.. Proc. Natl Acad. Sci. USA. 102: 17525-17530. 14. Duverger, A.., Jackson, RJ., van Ginkel, FW., Fischer, R., Tafaro, A., Leppla, SH., Fujihashi, K., Kiyono, H.., McGhee, JR., and Boyaka, PN. 2006. Bacillus anthracis Edema toxin acts as an adjuvant for mucosal immune responses to nasally administered vaccine antigens. J. Immunol. 176(3):1776-83. 15. Jang, MH., Sougawa, N., Tanaka, T., Hirata, T., Hiroi, T., Tohya, K., Guo, Z., Umemoto, E., Ebisuno, Y., Yang, BG., Seoh, JY., Lipp, M.., Kiyono, H.. and Miyasaka, M. 2006. CCR7 is critically important for migration of dendritic cells in intestinal lamina propria to mesenteric lymph nodes. J. Immunol. 176(2):803-10. 16. Hagiwara, Y., Kawamura, Y., Kataoka, K., Rahima, B., Jackson, R.J., Komase, K., Dohi, T., Boyaka, P.N., Takeda, Y., Kiyono, H., McGhee, J.R., and Fujihashi, K . 2006. A socond generation of double mutant cholera toxin adjuvants: Enhanced immunity without intracellular trafficking.. J. Immunol. 177(5): 3045-54. 17. Fukuyama, S., Nagatake, T., Kim, D.Y., Takamura, K., Park, E.J., Kaisho, T., Tanaka, N., Kurono, Y., and Kiyono, H. 2006. Cutting Edge: Uniqueness of lymphoid chemokine requirement for the initiation and maturation of nasopharynx-associated lymphoid tissue organogenesis. J. Immunol. 177(7): 4276-80. 18. Maddaloni, M., Staats H.F., Mierzejewska, D., Hoyt, T., Robinson, A., Callis, G., Kozaki, S., Kiyono, H., McGhee, J.R., Fujihashi, K., and Pascual, D.W. 2006. Mucosal vaccine targeting imoproves onset of mucosal and systemic immunity to Botulinum nuurotoxin A (BoTN/A). J. Immunol. 177(8): 5524-32. 19. Nochi, T. and Kiyono, H.. 2006. Innate Immunity in the mucosal immune system. Curr. Pharm. Des. 12:4203-13. 20.Kunisawa, J., Takahashi, I., and Kiyono, H. 2007. Intraepithelial lymphocytes: Their shared and divergent immunological behaviors in the small and large intestine. Immunol. Rev. 215(1):136-153. 21. Kim, N.J., Kunisawa, J., Kweon, M.N., Ji, G.E.., and Kiyono, H. 2007. Oral feeding of Bifidobacterium bifidum (BGN4) prevents CD4+ CD45RBhigh T cell-mediated inflammatory bowel disease by inhibition of disordered T Cell Activation. Clin.. Immunol.123(1):30-9. 22. Tanaka, N.., Fukuyama, S., Fukuiwa.. Kawabata, M., Sagara, Y., Ito, H., Miwa, Y., Nagatake, T., Kiyono, H. and Kurono, Y. 2007 Intranasal immunization with phosphorylcholine induces antigen specific mucosal and systemic immune responses in mice. Vaccine 30;25(14):2680-7. 23. Tamagawa, H., Hiroi, T., Mizushima, T., Ito, T., Matsuda, H., and Kiyono, H. 2007. Therapeutic effects of roxithromycin in interleukin-10-deficient colitis. Inflamm. Bowel Dis. 13(5):547-56. 24. Kunisawa, J., Kurashima, Y., Gohda, M., Higuchi, M,. Ishikawa, I,. Miura, F., Ogahara, I., and Kiyono, H. 2007. Sphingosine 1-phosphate regulates peritoneal B cell trafficking for subsequent intestinal IgA production. Blood 1;109(9):3749-56. 25. McGhee, J.R., Kunisawa, J., and Kiyono, H. Gut lymphocyte migration: we are halfway 'home'. Trend. Immunol. 28(4):150-3. 26. Takayama, N., Igarashi, O., Kweon, M.N., and Kiyono, H. Regulatory role of Peyer's patches for the inhibition of OVA-induced allergic diarrhea. Clin. Immunol. 123(2):199-208. 27. Kunisawa, J., McGhee, J.R.., and Kiyono, H. 2007. Mucosal s-IgA enhancement: development of safe and effective mucosal adjuvants and mucosal antigen delivery vehicles. Mucosal Immune Defense: Immunoglobulin A. (Edited by Charlotte S. Kaetzel), Kluwer Academic/Plenum Publishers, New York. 345-389. 28. Makita, S., Kanai, T., Nemoto, Y., Totsuka, T., Okamoto, R., Tsuchiya, K., Yamamoto, M., Kiyono, H., and Watanabe, M. 2007. Intestinal Lamina Propria Retaining CD4+CD25+ Regulatory T Cells Is ASuppressive Site of Intestinal Inflammation J. Immunol. 178(8):4937-46. 29. Fukuyama, S.,Kiyono, H.. 2007.Neuroregulator RET initiates Peyer's-patch tissue genesis. Immunity. 26(4):393-5. 30. Nagai, S., Mimuro, H., Yamada, T., Baba, Y., Moro, K., Nochi, T., Kiyono, H., Suzuki, T., Sasakawa, C., Koyasu, S.. 2007. Role of Peyer's patches in the induction of Helicobacter pylori-induced gastritis. Proc Natl Acad Sci U S A.. 104(21):8971-6. 31. Ohka, S., Igarashi, H., Nagata, N., Sakai, M., Koike, S., Nochi, T., Kiyono, H., Nomoto, A.. 2007. Establishment of a poliovirus oral infection system in human poliovirus receptor (hPVR/CD155)-expressing transgenic mice that are deficient in interferon-{alpha}/{beta} receptor. J Virol. 81(15):7902-12. 32. Nochi, T., Takagi, H., Yuki, Y., Yang, L., Masumura, T., Mejima, M., Nakanishi, U., Matsumura, A., Uozumi, A., Hiroi, T., Morita, S., Tanaka, K., Takaiwa, F., Kiyono, H.. 2007. From the Cover: Rice-based mucosal vaccine as a global strategy for cold-chain- and needle-free vaccination. Proc Natl Acad Sci U S A. 26;104(26):10986-91. 33. Kurashima, Y., Kunisawa, J., Higuchi, M., Ghoda, M., Ishikawa, I., Takayama, N., Shimizu, M., Kiyono, H.. 2007. Sphingosine 1-phosphate-mediated trafficking of pathogenic th2 and mast cells for the control of food allergy. J Immunol.179(3):1577-85. 34. Yuki, Y., Nochi, T., Kiyono, H.. 2007. Progress towards an AIDS mucosal vaccine: An overview. Tuberculosis (Edinb). 35. Kunisawa, J., Kurashima, Y., Higuchi, M, Gohda, M., . Ishikawa, I,. Ogahara, I., Kim, N., and Kiyono, H. 2007. Sphingosine 1-phosphate dependence in the regulation of lymphocyte trafficking to the gut epithelium. J Exp Med.204(10):2335-48 36. Kiyono, H., Kunisawa, J., McGhee, J.R., and Mestecky, J.. 2007. The mucosal immune system, Fundamental Immunology (Edited by William, E., Paul,). Lippincott-Raven, Philadelphia. 37. Nochi,T., Yuki,Y., Matsumura,A., Mejima,M., Terahara,K., Kim,D., Fukuyama,S., Iwatsuki-Horimoto,K., Kawaoka,Y., Kohda,T., Kozaki,S., Igarashi,O., and Kiyono, H.. 2007. A novel M-cell-specific carbohydrate-targeted mucosal vaccine effectively induces antigen-specific immune responses.J Exp Med.204(12):2789-96 38. Hashizume, T., Togawa, A., Nochi, T., Igarashi, O., Kweon, MN., Kiyono, H., Yamamoto, M.. 2007. Peyer's Patches Are Required for Intestinal IgA Responses to Salmonella.Infect Immun. 39.Chang SY, Cha HR, Uematsu S, Akira S, Igarashi O, Kiyono H, Kweon MN.. 2008. Colonic patches direct the cross-talk between systemic compartments and large intestine independently of innate immunity. J Immunol　180　3:1609-18. 40. Kunisawa J, Gohda M, Kurashima Y, Ishikawa I, Higuchi M, Kiyono H. 2008. Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NF{kappa}B-inducing kinase in stromal cells. Blood. 41.Ooi EL, Verjan N, Hirono I, Nochi T, Kondo H, Aoki T, Kiyono H, Yuki Y. 2008. Biological characterisation of a recombinant Atlantic salmon type I interferon synthesized in Escherichia coli.Fish Shellfish Immunol.24(5):506-13. 42. Kurashima Y, Kunisawa J, Kiyono H. 2008. Applicable strategies for the mucosal immune system in the regulation of allergic diseases. Arerugi.57(2):87-94. 43. Chang SY, Cha HR, Igarashi O, Rennert PD, Kissenpfennig A, Malissen B, Nanno M, Kiyono H, Kweon MN. 2008. Cutting edge: langerin+ dendritic cells in the mesenteric lymph node set the stage for skin and gut immune system cross-talk. J Immunol. 180(7):4361-5. 44. Gohda M, Kunisawa J, Miura F, Kagiyama Y, Kurashima Y, Higuchi M, Ishikawa I, Ogahara I, Kiyono H. 2008. Sphingosine 1-phosphate regulates the egress of IgA plasmablasts from Peyer's patches for intestinal IgA responses. J Immunol. 180(8):5335-43. 45. Momoi F, Hashizume T, Kurita-Ochiai T, Yuki Y, Kiyono H, Yamamoto M. 2008. Nasal Vaccination with Outer Membrane Protein of Porphyromonas gingivalis and Nontoxic Chimeric Enterotoxin Adjuvant Induces Long-Term Protective Immunity with Reduced IgE Antibodies. Infect Immun. 46. Ooi EL, Verjan N, Haraguchi I, Oshima T, Kondo H, Hirono I, Aoki T, Kiyono H, Yuki Y. 2008. Innate immunomodulation with recombinant interferon-alpha enhances resistance of rainbow trout (Oncorhynchus mykiss) to infectious hematopoietic necrosis virus. Dev Comp Immunol. 47. Kobayashi T, Takahashi K, Nagai Y, Shibata T, Otani M, Izui S, Akira S, Gotoh Y, Kiyono H, Miyake K.. 2008. Tonic B cell activation by Radioprotective105/MD-1 promotes disease progression in MRL/lpr mice.Int Immunol. 20　7:881-91. 48. Verjan N, Ooi EL, Nochi T, Kondo H, Hirono I, Aoki T, Kiyono H, Yuki Y. 2008. A soluble nonglycosylated recombinant infectious hematopoietic necrosis virus (IHNV) G-protein induces IFNs in rainbow trout (Oncorhynchus mykiss). Fish Shellfish Immunol. 25　1-2:170-80. 49. Uematsu S, Fujimoto K, Jang MH, Yang BG, Jung YJ, Nishiyama M, Sato S, Tsujimura T, Yamamoto M, Yokota Y, Kiyono H, Miyasaka M, Ishii KJ, Akira S. 2008. Regulation of humoral and cellular gut immunity by lamina propria dendritic cells expressing Toll-like receptor 5. Nat Immunol. 97:769-76. 50. Terahara K, Yoshida M, Igarashi O, Nochi T, Pontes GS, Hase K, Ohno H, Kurokawa S, Mejima M, Takayama N, Yuki Y, Lowe AW, Kiyono H. 2008. Comprehensive gene expression profiling of Peyer's patch M cells, villous M-like cells, and intestinal epithelial cells. J Immunol. 15;180(12):7840-6. 51. Caipang CM, Verjan N, Ooi EL, Kondo H, Hirono I, Aoki T, Kiyono H, Yuki Y. 2008. Enhanced survival of shrimp, Penaeus (Marsupenaeus) japonicus from white spot syndrome disease after oral administration of recombinant VP28 expressed in Brevibacillus brevis. Fish Shellfish Immunol. 52. Kunisawa J, Nochi T, Kiyono H.. 2008. Immunological commonalities and distinctions between airway and digestive immunity. Trends Immunol. 53. Fehervari Z, Kiyono H.. 2008.The mucosa: at the frontlines of immunity.Trends Immunol. 54.Yuki Y, Kiyono H.. 2008.MucoRice: development of rice-based oral vaccine.Nihon Rinsho Meneki Gakkai Kaishi 55.Terahara K, Yoshida M, Taguchi F, Igarashi O, Nochi T, Gotoh Y, Yamamoto T, Tsunetsugu-Yokota Y, Beauchemin N, Kiyono H. 2009. Expression of newly identified secretory CEACAM1(a) isoforms in the intestinal epithelium. Biochem Biophys Res Commun. 383(3):340-6 56. Kim D, Kim SH, Park EJ, Kim J, Cho SH, Kagawa J, Arai N, Jun K, Kiyono H, Kim S. 2009 Suppression of allergic diarrhea in murine ovalbumin-induced allergic diarrhea model by PG102, a water-soluble extract prepared from Actinidia arguta. Int Arch Allergy Immunol. 150(2):164-71 57.Takahashi I, Nochi T, Yuki Y, Kiyono H. 2009 New horizon of mucosal immunity and vaccines. Curr Opin Immunol. 21(3):352-8 58. Fujihashi K, Kiyono H. 2009 Mucosal immunosenescence: new developments and vaccines to control infectious diseases. Trends Immunol.30(7):334-43 59. Yuki Y, Kiyono H. 2009 Mucosal vaccines: novel advances in technology and delivery. Expert Rev Vaccines.8(8):1083-97 60. Yuki Y, Tokuhara D, Nochi T, Yasuda H, Mejima M, Kurokawa S, Takahashi Y, Kataoka N, Nakanishi U, Hagiwara Y, Fujihashi K, Takaiwa F, Kiyono H. 2009 Oral MucoRice expressing double-mutant cholera toxin A and B subunits induces toxin-specific neutralising immunity. Vaccine.27(43)5982-8 61. Mavichak R, Takano T, Kondo H, Hirono I, Wada S, Hatai K, Inagawa H, Takahashi Y, Yoshimura T, Kiyono H, Yuki Y, Aoki T. 2009 The effect of liposome-coated recombinant protein VP28 against white spot syndrome virus in kuruma shrimp, Marsupenaeus japonicus. J Fish Dis.33(1)69-74 62. Suzuki R, Nourani MR, Saino-Saito S, Abe H, Nochi T, Kiyono H, Spener F, Kondo H, Owada Y. 2009 Localization of fatty acid binding protein of epidermal type common to dendritic cells and presumptive macrophages in Peyer's patches and epithelial M cells of mouse intestine.Histochem Cell Biol.132(6):577-84 63. Nagatake T, Fukuyama S, Kim DY, Goda K, Igarashi O, Sato S, Nochi T, Sagara H, Yokota Y, Jetten AM, Kaisho T, Akira S, Mimuro H, Sasakawa C, Fukui Y, Fujihashi K, Akiyama T, Inoue J, Penninger JM, Kunisawa J, Kiyono H. 2009 Id2-, RORgammat-, and LTbetaR-independent initiation of lymphoid organogenesis in ocular immunity. J Exp Med.206(11):2351-64 64. Knoop KA, Kumar N, Butler BR, Sakthivel SK, Taylor RT, Nochi T, Akiba H, Yagita H, Kiyono H, Williams IR. 2009 RANKL is necessary and sufficient to initiate development of antigen-sampling M cells in the intestinal epithelium.J Immunol. 183(9):5738-47 65. Nochi T, Yuki Y, Katakai Y, Shibata H, Tokuhara D, Mejima M, Kurokawa S, Takahashi Y, Nakanishi U, Ono F, Mimuro H, Sasakawa C, Takaiwa F, Terao K, Kiyono H. 2009 A rice-based oral cholera vaccine induces macaque-specific systemic neutralizing antibodies but does not influence pre-existing intestinal immunity.J Immunol. 183(10):6538-44 66. Hase K, Kawano K, Nochi T, Pontes GS, Fukuda S, Ebisawa M, Kadokura K, Tobe T, Fujimura Y, Kawano S, Yabashi A, Waguri S, Nakato G, Kimura S, Murakami T, Iimura M, Hamura K, Fukuoka S, Lowe AW, Itoh K, Kiyono H, Ohno H. 2009 Uptake through glycoprotein 2 of FimH(+) bacteria by M cells initiates mucosal immune response.Nature.462(7270):226-30 67. Umehara T, Udagawa J, Takamura K, Kimura M, Ishimitsu R, Kiyono H, Kawauchi H, Otani H. 2009 Role of interleukin-15 in the development of mouse olfactory nerve. Congenit Anom (Kyoto). 49(4):253-7 68.Takahashi I.., Nochi T., Kunisawa J., Yuki Y., and Kiyono H. 2010 The mucosal immune system for secretory IgA responses and mucosal vaccine development. Inflammation and Regeneration 30: 40-47 69. Takahashi I., Fujihashi K. and Kiyono H. 2010 Mucosal regulatory cells in the gastrointestinal tract and periodontium. Periodontology 54(1): 247-56 70. Fuglem B.., Kiyono H., Nochi T., Yuki Y.., and Koppang EO. 2010 Antigen-sampling cells in the salmonid intestinal epithelium. Developmental and Comparative Immunology 34(7): 768-74 71. Obata T., Goto Y., Kunisawa J., Sato S.., Shibata N., Gohda M., Kagiyama Y., Nochi T., Yuki Y., Fukuyama Y.., and Kiyono H. 2010 Indigenous opportunistic bacteria inhabit mammalian gut-associated lymphoid tissues and share a mucosal antibody-mediated symbiosis. Proc Natl Acad Sci U S A. 107(16): 7419-24 72. Tokuhara D., Yuki Y., Nochi T.., Mejima M., Kurokawa S., Takahashi Y.., Nakanishi U.., and Kiyono H. 2010 Secretory IgA-mediated protection against V. Cholerae and heat-labile enterotoxin-producing enterotoxigenic Escherichia coli by rice-based vaccine. Proc Natl Acad Sci U S A. 107(19): 8794-9 73. Kunisawa J. and Kiyono H. 2010 Aberrant Interaction of the Gut Immune System with Environmental Factors in the Development of Food Allergies. Curr Allergy Asthma Rep 10(3): 215-21 74. Malamut G..,Kiyono H.., and Meresse B. 2010 IL-15 triggers an antiapoptotic pathway in human intraepithelial lymphocytes that is a potential new target in celiac disease-associated inflammation and lymphomagenesis. J Clin Invest 120(6): 2131-43 75. Nochi T, Yuki Y, Takahashi H, Sawada S, Mejima M, Kohda T, Harada N, Kong IG, Sato A, Kataoka N, Tokuhara D, Kurokawa S, Takahashi Y, Tsukada H, Kozaki S, Akiyoshi K and Kiyono H. 2010 Nanogel antigenic protein-delivery system for adjuvant-free intranasal vaccines. Nat Mater 9(7): 572-8 76. Omoe K.., Kiyono H.., and Imanishi K. 2010 High affinity of interaction between superantigen and TCR Vβ molecules induces a high level and prolonged expansion of superantigen-reactive CD4+ T cells. J Biol Chem. 285(40): 30427-35 77. Kayamoto H.., Kunisawa J., Kiyono H.., and Tsunoda SI. 2010 Interleukin-1 family cytokines as mucosal vaccine adjuvants for induction of protective immunity against influenza virus. J Virol 84(24): 12703-12 78. Yuki Y., Nochi T., Harada N., Katakai Y., Shibata H., Mejima M., Kohda T., Tokuhara D., Kurokawa S., Takahashi Y., Ono F., Kozaki S., Terao K., Tsukada H. and Kiyono H. 2010 In Vivo Molecular Imaging Analysis of a Nasal Vaccine That Induces Protective Immunity against Botulism in Nonhuman Primates. J Immunol 185(9): 5436-43
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