Division of Cellular and Molecular Biology
The Institute of Medical Science
The University of Tokyo
The Institute of Medical Science
The University of Tokyo
Taishin Akiyama, Ph.D. Associate Professor
[Position] Associate Professor, Institute of Medical Science, University of Tokyo
[Address] 4-6-1 Shirokane-dai, Minato-ku, Tokyo, 108-8639 Japan
[Phone] 81-3-5449-5276
[Fax] 81-3-5449-5421
[E-mail] : taishin@ims.u-tokyo.ac.jp
Carrer
[Education]
1987 B.D. Hiroshima University, Faculty of Medicine
1989 Master D. Kyoto University, Graduate School of Pharmaceutical Science
1992 Ph.D. Kyoto University, Graduate School of Pharmaceutical Science
[Professional Career]
Research Fellowships:
1992-1993: Research Associate in Graduate School of Pharmaceutical Science, Kyoto University.
1993-1997: Research Associate in Department of Physiology and Biophysics, Baylor College of Medicine 1997-2000: Postdoctoral Fellow of Japan Society for the Promotion of Science
Academic Appointments:
2000-2002: Lecturer, Faculty of Science and Technology, Keio University, Japan
2002-2008: Lecturer, Institute of Medical Science, University of Tokyo
2007-2010: PRESTO Researcher, Japan Science and Technology Agency
2008-present: Associate Professor, Institute of Medical Science, University of Tokyo
Research interests
Immunologial self-tolerance
Lymphoid organogenesis
T cell signals
Selected publication
1. Mouri Y., Yano M., Shinzawa M., Shimo Y., Hirota F., Nishikawa Y, Nii T., Kiyonari H., Abe T., Uehara H., Izumi K., Tamada K., Chen L., Penninger JM., Inoue J., Akiyama T*, and Matsumoto M.
“Lymphotoxin Signal Promotes Thymic Organogenesis by Eliciting RANK Expression in the Embryonic Thymic Stroma”
J. Immunol., 186, 5047-57 (2011)
2. Shinzawa M., Maruyama Y., Qin J., Akiyama N., Miyauchi M., Yanai H., Takami M., Inoue J., and Akiyama T*.
“Splenic extramedullary hemopoiesis caused by a dysfunctional mutation in the NF-kB-inducing kinase gene”
Biochem. Biophys. Res. Commun., 414, 773-778 (2011)
3. Shimo Y., Yanai H., Ohshima D., Qin J., Motegi H., Maruyama Y., Hori S., Inoue J., and Akiyama T*.
“TRAF6 directs commitment to regulatory T cells in thymocytes”
Genes Cells., 16, 437-447 (2011)
4. Akiyama T*, Shimo Y, Yanai H, Qin J, Ohsima, D, Maruyama Y, Asaumi Y, Kitazawa J, Takayanagi H, Penninger JM, Matsumoto M, Nitta T, Takahama Y, & Inoue J.
The Tumor necrosis family receptors RANK and CD40 cooperatively establish the thymic medullary microenvironment and self-tolerance
Immunity, 29, 423-437 (2008).
5. Qin J, Konno H, Ohshima D, Yanai H, Motegi H, Shimo Y, Hirota F, Matsumoto M, Takaki S, Inoue J, & Akiyama T*.
Developmental stage-dependent collaboration between the TRAF6 and lymphotoxin pathways for B-cell follicle organization in secondary lymphoid organs.
J. Immunol. 179, 6799-6807 (2007).
6. Akiyama T, Maeda S, Yamane S, Ogino K, Kasai M, Kajiura F, Matsumoto M, & Inoue J.
Dependence of Self-tolerance on TRAF6-directed Development of Thymic Stroma.
Science 308, 248-251 (2005).
7. Akiyama T & Hogan ME.
The design of an agent to bend DNA.
Proc. Natl. Acad. Sci USA 93, 12122-12127 (1996).
8. Akiyama T, Simeno F, Murakami M, & Yoneda F.
Flavin-6-carboxylic Acids as Novel and Simple Flavoenzyme Models. Nonenzymatic Stabilization of the Flavin Semiquinone Radical and the 4a-Hydroperoxyflavin by Intramolecular Hydrogen Bonding.
J. Am. Chem. Soc. 114, 6613-6620 (1992).
